Ciprofloxacin

Ciprofloxacin

Ciprofloxacin Recall

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Questions & Answers

Side Effects & Adverse Reactions

Fluoroquinolones, including Ciprofloxacin Tablets USP, 250 mg, 500 mg and 750 mg, are associated with an increased risk of tendinitis and tendon rupture in all ages. This adverse reaction most frequently involves the Achilles tendon, and rupture of the Achilles tendon may require surgical repair. Tendinitis and tendon rupture in the rotator cuff (the shoulder), the hand, the biceps, the thumb, and other tendon sites have also been reported. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. Factors, in addition to age and corticosteroid use, that may independently increase the risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis. Tendinitis and tendon rupture have also occurred in patients taking fluoroquinolones who do not have the above risk factors. Tendon rupture can occur during or after completion of therapy; cases occurring up to several months after completion of therapy have been reported. Ciprofloxacin Tablets USP, 250 mg, 500 mg and 750 mg should be discontinued if the patient experiences pain, swelling, inflammation or rupture of a tendon. Patients should be advised to rest at the first sign of tendinitis or tendon rupture, and to contact their healthcare provider regarding changing to a non-quinolone antimicrobial drug.

 

THE SAFETY AND EFFECTIVENESS OF CIPROFLOXACIN IN PREGNANT AND LACTATING WOMEN HAVE NOT BEEN ESTABLISHED.

(See

PRECAUTIONS: Pregnancy,

and

Nursing Mothers

subsections.)

 

Ciprofloxacin should be used in pediatric patients (less than 18 years of age) only for infections listed in the

INDICATIONS AND USAGE

section. An increased incidence of adverse events compared to controls, including events related to joints and/or surrounding tissues, has been observed. (See

ADVERSE REACTIONS

.)

In pre-clinical studies, oral administration of ciprofloxacin caused lameness in immature dogs. Histopathological examination of the weight-bearing joints of these dogs revealed permanent lesions of the cartilage. Related quinolone-class drugs also produce erosions of cartilage of weight-bearing joints and other signs of arthropathy in immature animals of various species. (See

ANIMAL PHARMACOLOGY

.)

 

Ciprofloxacin is an inhibitor of the hepatic CYP1A2 enzyme pathway. Coadministration of ciprofloxacin and other drugs primarily metabolized by CYP1A2 (e.g. theophylline, methylxanthines, tizanidine) results in increased plasma concentrations of the coadministered drug and could lead to clinically significant pharmacodynamic side effects of the coadministered drug.

 

Convulsions, increased intracranial pressure, and toxic psychosis have been reported in patients receiving quinolones, including ciprofloxacin. Ciprofloxacin may also cause central nervous system (CNS) events including: dizziness, confusion, tremors, hallucinations, depression, and, rarely, suicidal thoughts or acts. These reactions may occur following the first dose. If these reactions occur in patients receiving ciprofloxacin, the drug should be discontinued and appropriate measures instituted. As with all quinolones, ciprofloxacin should be used with caution in patients with known or suspected CNS disorders that may predispose to seizures or lower the seizure threshold (e.g. severe cerebral arteriosclerosis, epilepsy), or in the presence of other risk factors that may predispose to seizures or lower the seizure threshold (e.g. certain drug therapy, renal dysfunction). (See

PRECAUTIONS: General, Information for Patients, Drug Interactions

and

ADVERSE REACTIONS

.)

 

SERIOUS AND FATAL REACTIONS HAVE BEEN REPORTED IN PATIENTS RECEIVING CONCURRENT ADMINISTRATION OF CIPROFLOXACIN AND THEOPHYLLINE.

These reactions have included cardiac arrest, seizure, status epilepticus, and respiratory failure. Although similar serious adverse effects have been reported in patients receiving theophylline alone, the possibility that these reactions may be potentiated by ciprofloxacin cannot be eliminated. If concomitant use cannot be avoided, serum levels of theophylline should be monitored and dosage adjustments made as appropriate.

 

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving quinolone therapy. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, tingling, pharyngeal or facial edema, dyspnea, urticaria, and itching. Only a few patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency treatment with epinephrine. Oxygen, intravenous steroids, and airway management, including intubation, should be administered as indicated.

 

Other serious and sometimes fatal events, some due to hypersensitivity, and some due to uncertain etiology, have been reported rarely in patients receiving therapy with quinolones, including ciprofloxacin. These events may be severe and generally occur following the administration of multiple doses. Clinical manifestations may include one or more of the following:

 

  • fever, rash, or severe dermatologic reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome);
  • vasculitis; arthralgia; myalgia; serum sickness;
  • allergic pneumonitis;
  • interstitial nephritis; acute renal insufficiency or failure;
  • hepatitis; jaundice; acute hepatic necrosis or failure;
  • anemia, including hemolytic and aplastic; thrombocytopenia, including thrombotic thrombocytopenic purpura; leukopenia; agranulocytosis; pancytopenia; and/or other hematologic abnormalities.

 

The drug should be discontinued immediately at the first appearance of a skin rash, jaundice, or any other sign of hypersensitivity and supportive measures instituted (See PRECAUTIONS: Information for Patients and ADVERSE REACTIONS).

 

Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Ciprofloxacin Tablets USP, 250 mg, 500 mg and 750 mg, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.

C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.

 

Rare cases of sensory or sensorimotor axonal polyneuropathy affecting small and/or large axons resulting in paresthesias, hypoesthesias, dysesthesias and weakness have been reported in patients receiving quinolones, including ciprofloxacin. Ciprofloxacin should be discontinued if the patient experiences symptoms of neuropathy including pain, burning, tingling, numbness, and/or weakness, or is found to have deficits in light touch, pain, temperature, position sense, vibratory sensation, and/or motor strength in order to prevent the development of an irreversible condition.

 

Ciprofloxacin has not been shown to be effective in the treatment of syphilis. Antimicrobial agents used in high dose for short periods of time to treat gonorrhea may mask or delay the symptoms of incubating syphilis. All patients with gonorrhea should have a serologic test for syphilis at the time of diagnosis. Patients treated with ciprofloxacin should have a follow-up serologic test for syphilis after three months.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Ciprofloxacin Tablets USP, 250 mg, 500 mg and 750 mg is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions and patient populations listed below. Please see

DOSAGE AND ADMINISTRATION

for specific recommendations.

 

Urinary Tract Infections

caused by

Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa,

methicillin-susceptible

Staphylococcus epidermidis, Staphylococcus saprophyticus,

or

Enterococcus faecalis.



Acute Uncomplicated Cystitis in females

caused by

Escherichia coli

or

Staphylococcus saprophyticus.



Chronic Bacterial Prostatitis

caused by

Escherichia coli

or

Proteus mirabilis.



Lower Respiratory Tract Infections

caused by

Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus parainfluenzae,

or penicillin-susceptible

Streptococcus pneumoniae.

Also,

Moraxella catarrhalis

for the treatment of acute exacerbations of chronic bronchitis.

NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the treatment of presumed or confirmed pneumonia secondary to

Streptococcus pneumoniae.



Acute Sinusitis

caused by

Haemophilus influenzae,

penicillin-susceptible

Streptococcus pneumoniae,

or

Moraxella catarrhalis.



Skin and Skin Structure Infections

caused by

Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii, Pseudomonas aeruginosa,

methicillin-susceptible

Staphylococcus aureus,

methicillin-susceptible

Staphylococcus epidermidis,

or

Streptococcus pyogenes.



Bone and Joint Infections

caused by

Enterobacter cloacae, Serratia marcescens,

or

Pseudomonas aeruginosa.



Complicated Intra-Abdominal Infections

(used in combination with metronidazole) caused by

Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae,

or

Bacteroides fragilis.



Infectious Diarrhea

caused by

Escherichia coli

(enterotoxigenic strains),

Campylobacter jejuni, Shigella boydii

,

Shigella dysenteriae, Shigella flexneri

or

Shigella sonnei

when antibacterial therapy is indicated.



Typhoid Fever (Enteric Fever)

caused by

Salmonella typhi.

NOTE: The efficacy of ciprofloxacin in the eradication of the chronic typhoid carrier state has not been demonstrated.


Uncomplicated cervical and urethral gonorrhea

due to

Neisseria gonorrhoeae.

 

Complicated Urinary Tract Infections and Pyelonephritis

due to

Escherichia coli.

NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse events compared to controls, including events related to joints and/or surrounding tissues. (See

WARNINGS, PRECAUTIONS, Pediatric Use, ADVERSE REACTIONS

and

CLINICAL STUDIES

.)

Ciprofloxacin, like other fluoroquinolones, is associated with arthropathy and histopathological changes in weight-bearing joints of juvenile animals. (See

ANIMAL PHARMACOLOGY

.)

 

Inhalational anthrax

(post-exposure): To reduce the incidence or progression of disease following exposure to aerosolized

Bacillus anthracis.

Ciprofloxacin serum concentrations achieved in humans served as a surrogate endpoint reasonably likely to predict clinical benefit and provided the initial basis for approval of this indication.

5

Supportive clinical information for ciprofloxacin for anthrax post-exposure prophylaxis was obtained during the anthrax bioterror attacks of October 2001.  (See also,

INHALATIONAL ANTHRAX – ADDITIONAL INFORMATION

).

  

Although treatment of infections due to this organism in this organ system demonstrated a clinically significant outcome, efficacy was studied in fewer than 10 patients.

If anaerobic organisms are suspected of contributing to the infection, appropriate therapy should be administered. Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to ciprofloxacin. Therapy with Ciprofloxacin Tablets USP, 250 mg, 500 mg and 750 mg may be initiated before results of these tests are known; once results become available appropriate therapy should be continued. As with other drugs, some strains of

Pseudomonas aeruginosa

may develop resistance fairly rapidly during treatment with ciprofloxacin. Culture and susceptibility testing performed periodically during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ciprofloxacin Tablets USP, 250 mg, 500 mg and 750 mg and other antibacterial drugs, Ciprofloxacin Tablets USP, 250 mg, 500 mg and 750 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

 

History

There is currently no drug history available for this drug.

Other Information

Ciprofloxacin Hydrochloride Tablets USP, 250 mg, 500 mg and 750 mg are synthetic broad spectrum antimicrobial agents for oral administration. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. It is a faintly yellowish to light yellow crystalline substance with a molecular weight of 385.8. Its empirical formula is C

17

H

18

FN

3

O

3

•HCl•H

2

O and its chemical structure is as follows: 

MM1

Ciprofloxacin is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Its empirical formula is C

17

H

18

FN

3

O

3

and its molecular weight is 331.4. It is a faintly yellowish to light yellow crystalline substance and its chemical structure is as follows: 

MM2

Ciprofloxacin Tablets USP are film-coated tablets and are available in 250 mg, 500 mg and 750 mg (ciprofloxacin equivalent) strengths. Ciprofloxacin Tablets are white to slightly yellowish. The inactive ingredients are pregelatinized starch, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol and purified water.

 

Ciprofloxacin Manufacturers


  • Remedyrepack Inc.
    Ciprofloxacin Tablet [Remedyrepack Inc. ]
  • Mckesson Packaging Services A Business Unit Of Mckesson Corporation
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Mckesson Packaging Services A Business Unit Of Mckesson Corporation]
  • Henry Schein Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Henry Schein Inc.]
  • Proficient Rx Lp
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Proficient Rx Lp]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Lake Erie Medical Dba Quality Care Products Llc]
  • Blenheim Pharmacal, Inc.
    Ciprofloxacin Tablet, Film Coated [Blenheim Pharmacal, Inc.]
  • Cardinal Health
    Ciprofloxacin Tablet, Film Coated [Cardinal Health]
  • Golden State Medical Supply, Inc
    Ciprofloxacin Tablet, Film Coated [Golden State Medical Supply, Inc]
  • State Of Florida Doh Central Pharmacy
    Ciprofloxacin Tablet [State Of Florida Doh Central Pharmacy]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet [Remedyrepack Inc. ]
  • Proficient Rx Lp
    Ciprofloxacin Tablet, Film Coated [Proficient Rx Lp]
  • Preferred Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Preferred Pharmaceuticals, Inc.]
  • Taro Pharmaceuticals U.s.a., Inc.
    Ciprofloxacin Tablet [Taro Pharmaceuticals U.s.a., Inc.]
  • Pfizer Labs, Division Of Pfizer Inc
    Ciprofloxacin Injection, Solution, Concentrate Ciprofloxacin Injection, Solution [Pfizer Labs, Division Of Pfizer Inc]
  • Rebel Distributors Corp.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Rebel Distributors Corp.]
  • Testpak Holding Company
    Ciprofloxacin Tablet, Coated [Testpak Holding Company]
  • Kaiser Foundation Hospitals
    Ciprofloxacin Tablet, Film Coated [Kaiser Foundation Hospitals]
  • Stat Rx Usa Llc
    Ciprofloxacin Tablet [Stat Rx Usa Llc]
  • State Of Florida Doh Central Pharmacy
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [State Of Florida Doh Central Pharmacy]
  • Blenheim Pharmacal, Inc.
    Ciprofloxacin Tablet, Film Coated [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Ciprofloxacin Tablet [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Ciprofloxacin Tablet [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Ciprofloxacin Tablet, Film Coated [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Ciprofloxacin Tablet, Film Coated [Blenheim Pharmacal, Inc.]
  • Rebel Distributors Corp
    Ciprofloxacin Injection [Rebel Distributors Corp]
  • Pack Pharmaceuticals, Llc
    Ciprofloxacin Tablet [Pack Pharmaceuticals, Llc]
  • Stat Rx Usa Llc
    Ciprofloxacin Tablet, Film Coated [Stat Rx Usa Llc]
  • Remedyrepack Inc.
    Ciprofloxacin (Ciprofloxacin) Tablet [Remedyrepack Inc. ]
  • Redpharm Drug Inc.
    Ciprofloxacin Tablet [Redpharm Drug Inc.]
  • Redpharm Drug Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Redpharm Drug Inc.]
  • Redpharm Drug Inc.
    Ciprofloxacin Tablet, Film Coated [Redpharm Drug Inc.]
  • Bausch & Lomb Incorporated
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Bausch & Lomb Incorporated]
  • Rebel Distributors Corp
    Ciprofloxacin Injection, Solution, Concentrate [Rebel Distributors Corp]
  • Redpharm Drug Inc.
    Ciprofloxacin Tablet, Film Coated [Redpharm Drug Inc.]
  • Redpharm Drug Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Redpharm Drug Inc.]
  • Legacy Pharmaceutical Packaging
    Ciprofloxacin Tablet, Film Coated [Legacy Pharmaceutical Packaging]
  • Pd-rx Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Pd-rx Pharmaceuticals, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Pd-rx Pharmaceuticals, Inc.]
  • Akorn Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Akorn Inc.]
  • H.j. Harkins Company, Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [H.j. Harkins Company, Inc.]
  • Rebel Distributors Corp
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet [Rebel Distributors Corp]
  • Lake Erie Medical Dba Quality Care Products Llc
    Ciprofloxacin Tablet, Film Coated [Lake Erie Medical Dba Quality Care Products Llc]
  • Pd-rx Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Pd-rx Pharmaceuticals, Inc.]
  • Life Line Home Care Services, Inc.
    Ciprofloxacin Tablet [Life Line Home Care Services, Inc.]
  • Pack Pharmaceuticals, Llc
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Pack Pharmaceuticals, Llc]
  • Dr. Reddy’s Laboratories Limited
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated, Extended Release [Dr. Reddy’s Laboratories Limited]
  • Hhs/program Support Center/supply Service Center
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Hhs/program Support Center/supply Service Center]
  • West-ward Pharmaceutical Corp
    Ciprofloxacin Tablet, Film Coated [West-ward Pharmaceutical Corp]
  • Hhs/program Support Center/supply Service Center
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Hhs/program Support Center/supply Service Center]
  • Pd-rx Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Pd-rx Pharmaceuticals, Inc.]
  • Hhs/program Support Center/supply Service Center
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Hhs/program Support Center/supply Service Center]
  • Hhs/program Support Center/supply Service Center
    Ciprofloxacin Tablet, Film Coated [Hhs/program Support Center/supply Service Center]
  • Unit Dose Services
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Unit Dose Services]
  • Watson Pharma, Inc.
    Ciprofloxacin Tablet, Film Coated, Extended Release [Watson Pharma, Inc.]
  • Aurolife Pharma Llc
    Ciprofloxacin (Ciprofloxacin ) Tablet, Film Coated Ciprofloxacin Tablet, Film Coated [Aurolife Pharma Llc]
  • Carlsbad Technology, Inc.
    Ciprofloxacin Tablet, Film Coated [Carlsbad Technology, Inc.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Lake Erie Medical Dba Quality Care Products Llc]
  • Physicians Total Care, Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Physicians Total Care, Inc.]
  • Bryant Ranch Prepack
    Ciprofloxacin Tablet, Film Coated [Bryant Ranch Prepack]
  • Mckesson Packaging Services A Business Unit Of Mckesson Corporation
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Mckesson Packaging Services A Business Unit Of Mckesson Corporation]
  • Lake Erie Medical Dba Quality Care Products Llc
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Pd-rx Pharmaceuticals, Inc.
    Ciprofloxacin Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Unit Dose Services
    Ciprofloxacin Tablet [Unit Dose Services]
  • Bryant Ranch Prepack
    Ciprofloxacin Tablet, Film Coated [Bryant Ranch Prepack]
  • Lake Erie Medical Dba Quality Care Products Llc
    Ciprofloxacin Tablet, Film Coated [Lake Erie Medical Dba Quality Care Products Llc]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet, Film Coated [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet, Film Coated [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet, Film Coated [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet, Film Coated [Remedyrepack Inc. ]
  • Blenheim Pharmacal, Inc.
    Ciprofloxacin Tablet [Blenheim Pharmacal, Inc.]
  • Sandoz Inc
    Ciprofloxacin Injection [Sandoz Inc]
  • American Health Packaging
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [American Health Packaging]
  • Lake Erie Medical Dba Quality Care Products Llc
    Ciprofloxacin Tablet, Film Coated [Lake Erie Medical Dba Quality Care Products Llc]
  • Lake Erie Medical Dba Quality Care Products Llc
    Ciprofloxacin Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Clinical Solutions Wholesale
    Ciprofloxacin Tablet [Clinical Solutions Wholesale]
  • Medvantx, Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Medvantx, Inc.]
  • Remedyrepack Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Ciprofloxacin Tablet, Film Coated [Remedyrepack Inc. ]
  • West-ward Pharmaceutical Corp
    Ciprofloxacin Tablet, Film Coated [West-ward Pharmaceutical Corp]
  • Dr Reddy’s Laboratories
    Ciprofloxacin Tablet, Film Coated [Dr Reddy’s Laboratories]
  • Ranbaxy Pharmaceuticals Inc.
    Ciprofloxacin Tablet, Film Coated [Ranbaxy Pharmaceuticals Inc.]
  • Clinical Solutions Wholesale
    Ciprofloxacin Tablet, Film Coated [Clinical Solutions Wholesale]
  • Golden State Medical Supply, Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Golden State Medical Supply, Inc.]
  • Apotex Corp
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Apotex Corp]
  • Northstar Rx Llc
    Ciprofloxacin (Ciprofloxacin Hydrochloride ) Tablet, Film Coated [Northstar Rx Llc]
  • Remedyrepack Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Remedyrepack Inc. ]
  • Mylan Pharmaceuticals Inc.
    Ciprofloxacin Tablet, Film Coated [Mylan Pharmaceuticals Inc.]
  • Ivax Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Ivax Pharmaceuticals, Inc.]
  • Mylan Pharmaceuticals Inc.
    Ciprofloxacin Tablet, Film Coated, Extended Release [Mylan Pharmaceuticals Inc.]
  • Aidarex Pharmaceuticals Llc
    Ciprofloxacin Tablet [Aidarex Pharmaceuticals Llc]
  • St Marys Medical Park Pharmacy
    Ciprofloxacin (Ciprofloxacin) Tablet [St Marys Medical Park Pharmacy]
  • Sagent Pharmaceuticals
    Ciprofloxacin Injection [Sagent Pharmaceuticals]
  • Pd-rx Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Pd-rx Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc
    Ciprofloxacin Tablet [Preferred Pharmaceuticals, Inc]
  • Mylan Institutional Inc.
    Ciprofloxacin Tablet, Film Coated [Mylan Institutional Inc.]
  • Aphena Pharma Solutions – New Jersey, Llc
    Ciprofloxacin Tablet, Film Coated [Aphena Pharma Solutions – New Jersey, Llc]
  • Aphena Pharma Solutions – Tennessee, Llc
    Ciprofloxacin Tablet, Film Coated [Aphena Pharma Solutions – Tennessee, Llc]
  • Direct Rx
    Ciprofloxacin Tablet [Direct Rx]
  • Cardinal Health
    Ciprofloxacin Tablet, Film Coated [Cardinal Health]
  • Readymeds
    Ciprofloxacin Tablet, Film Coated [Readymeds]
  • Hospira, Inc.
    Ciprofloxacin Injection, Solution, Concentrate [Hospira, Inc.]
  • Lupin Pharmaceuticals, Inc.
    Ciprofloxacin ( Ciprofloxacin ) Kit [Lupin Pharmaceuticals, Inc.]
  • Avkare, Inc.
    Ciprofloxacin (Ciprofloxacin) Tablet, Film Coated [Avkare, Inc.]
  • Northwind Pharmaceuticals
    Ciprofloxacin Tablet [Northwind Pharmaceuticals]
  • Aurobindo Pharma Limited
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Aurobindo Pharma Limited]
  • Blu Pharmaceuticals, Llc
    Ciprofloxacin Tablet, Film Coated [Blu Pharmaceuticals, Llc]
  • A-s Medication Solutions Llc
    Ciprofloxacin Tablet, Film Coated [A-s Medication Solutions Llc]
  • Preferred Pharmaceuticals, Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Solution/ Drops [Preferred Pharmaceuticals, Inc.]
  • A-s Medication Solutions Llc
    Ciprofloxacin Tablet, Film Coated [A-s Medication Solutions Llc]
  • Bryant Ranch Prepack
    Ciprofloxacin Tablet, Film Coated [Bryant Ranch Prepack]
  • Claris Lifesciences Inc.
    Ciprofloxacin Injection, Solution Ciprofloxacin Injection, Solution, Concentrate [Claris Lifesciences Inc.]
  • Cardinal Health
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Cardinal Health]
  • Preferred Pharmaceuticals, Inc.
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Preferred Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Ciprofloxacin Tablet, Film Coated [Preferred Pharmaceuticals, Inc.]
  • Gen-source Rx
    Ciprofloxacin (Ciprofloxacin Hydrochloride) Tablet, Film Coated [Gen-source Rx]
  • Hikma Pharmaceutical
    Ciprofloxacin Tablet, Film Coated [Hikma Pharmaceutical]