Clindamycin Hydrochloride

Clindamycin Hydrochloride

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Questions & Answers

Side Effects & Adverse Reactions

See WARNING box.

Clostridium difficile associated diarrhea

Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including clindamycin, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon, leading to overgrowth of C. difficile.

C. difficile produces toxins A and B, which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy.

CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.

Severe Skin Reactions

Severe skin reactions such as Toxic Epidermal Necrolysis, some with fatal outcome, have been reported. In case of such an event, treatment should be permanently discontinued.

A careful inquiry should be made concerning previous sensitivities to drugs and other allergens.

Usage in Meningitis

Since clindamycin does not diffuse adequately into the cerebrospinal fluid, the drug should not be used in the treatment of meningitis.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Clindamycin is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria.

Clindamycin is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be re­served for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of co­li­tis, as described in the  WARNING box, before selecting clindamycin, the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).

Anaerobes: Serious respiratory tract infections such as empyema, anaerobic pneumonitis, and lung abscess; serious skin and soft tissue infections; septicemia; intra-abdominal infections such as peritonitis and intra-abdominal abscess (typically resulting from anaerobic organisms resident in the normal gastrointestinal tract); infections of the female pelvis and genital tract such as endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection.

Streptococci: Serious respiratory tract infections; serious skin and soft tissue infections.

Staphylococci: Serious respiratory tract infections; serious skin and soft tissue infections.

Pneumococci: Serious respiratory tract infections.

Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to clindamycin.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of clindamycin hydrochloride and other antibacterial drugs, clindamycin hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

History

There is currently no drug history available for this drug.

Other Information

Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin.

Clindamycin Hydrochloride Capsules, USP contain clindamycin hydrochloride equivalent to 150 mg or 300 mg of clindamycin.

Inactive ingredients: anhydrous lactose, magnesium stearate, starch (corn) and talc. The capsule shells contain: D&C Red No. 28, FD&C Blue No. 1, FD&C Red No. 40, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide. The 150 mg capsule shell also contains black iron oxide and yellow iron oxide.

The structural formula is represented below:

Structure

C 18H 33CIN 2O 5S•HCl          M.W. 461.44

The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl- trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L- threo-α-D- galacto-octopyranoside monohydrochloride.

Clindamycin Hydrochloride Manufacturers


  • Blenheim Pharmacal, Inc.
    Clindamycin Hydrochloride Capsule [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Clindamycin Hydrochloride Capsule [Blenheim Pharmacal, Inc.]
  • Kaiser Foundation Hospitals
    Clindamycin Hydrochloride Capsule [Kaiser Foundation Hospitals]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Unit Dose Services
    Clindamycin Hydrochloride Capsule [Unit Dose Services]
  • Unit Dose Services
    Clindamycin Hydrochloride Capsule [Unit Dose Services]
  • Preferred Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Preferred Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Preferred Pharmaceuticals, Inc.]
  • Stat Rx Usa
    Clindamycin Hydrochloride Capsule [Stat Rx Usa]
  • Kaiser Foundation Hospitals
    Clindamycin Hydrochloride Capsule [Kaiser Foundation Hospitals]
  • Contract Pharmacy Services-pa
    Clindamycin Hydrochloride Capsule, Gelatin Coated [Contract Pharmacy Services-pa]
  • Mckesson Packaging Services Business Unit Of Mckesson Corporation
    Clindamycin Hydrochloride Capsule [Mckesson Packaging Services Business Unit Of Mckesson Corporation]
  • Contract Pharmacy Services-pa
    Clindamycin Hydrochloride Capsule [Contract Pharmacy Services-pa]
  • Lake Erie Medical Dba Quality Care Products Llc
    Clindamycin Hydrochloride Capsule [Lake Erie Medical Dba Quality Care Products Llc]
  • Lake Erie Medical Dba Quality Care Products Llc
    Clindamycin Hydrochloride Capsule [Lake Erie Medical Dba Quality Care Products Llc]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Rebel Distributors Corp
    Clindamycin Hydrochloride Capsule [Rebel Distributors Corp]
  • Bryant Ranch Prepack
    Clindamycin Hydrochloride Capsule [Bryant Ranch Prepack]
  • Redpharm Drug Inc.
    Clindamycin Hydrochloride Capsule [Redpharm Drug Inc.]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Bryant Ranch Prepack
    Clindamycin Hydrochloride Capsule [Bryant Ranch Prepack]
  • Pd-rx Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Pd-rx Pharmaceuticals, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Pd-rx Pharmaceuticals, Inc.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Clindamycin Hydrochloride Capsule [Lake Erie Medical Dba Quality Care Products Llc]
  • Physicians Total Care, Inc.
    Clindamycin Hydrochloride Capsule [Physicians Total Care, Inc.]
  • Unit Dose Services
    Clindamycin Hydrochloride Capsule [Unit Dose Services]
  • Stat Rx Usa Llc
    Clindamycin Hydrochloride Capsule [Stat Rx Usa Llc]
  • Mylan Pharmaceuticals Inc.
    Clindamycin Hydrochloride Capsule [Mylan Pharmaceuticals Inc.]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Ranbaxy Pharmaceuticals Inc.
    Clindamycin Hydrochloride Capsule [Ranbaxy Pharmaceuticals Inc.]
  • Clinical Solutions Wholesale
    Clindamycin Hydrochloride Capsule Clindamycin Hydrochloride Capsule [Clinical Solutions Wholesale]
  • Liberty Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Liberty Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • A-s Medication Solutions Llc
    Clindamycin Hydrochloride Capsule [A-s Medication Solutions Llc]
  • Pd-rx Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Pd-rx Pharmaceuticals, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Pd-rx Pharmaceuticals, Inc.]
  • Cardinal Health
    Clindamycin Hydrochloride Capsule [Cardinal Health]
  • Major Pharmaceuticals
    Clindamycin Hydrochloride Capsule [Major Pharmaceuticals]
  • Aidarex Pharmaceuticals Llc
    Clindamycin Hydrochloride Capsule [Aidarex Pharmaceuticals Llc]
  • Greenstone Llc
    Clindamycin Hydrochloride Capsule [Greenstone Llc]
  • American Health Packaging
    Clindamycin Hydrochloride Capsule [American Health Packaging]
  • Kaiser Foundation Hospitals
    Clindamycin Hydrochloride Capsule [Kaiser Foundation Hospitals]
  • Direct Rx
    Clindamycin Hydrochloride Capsule [Direct Rx]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Mylan Institutional Inc.
    Clindamycin Hydrochloride Capsule [Mylan Institutional Inc.]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Northwind Pharmaceuticals
    Clindamycin Hydrochloride Capsule [Northwind Pharmaceuticals]
  • Northwind Pharmaceuticals
    Clindamycin Hydrochloride Capsule [Northwind Pharmaceuticals]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Proficient Rx Lp
    Clindamycin Hydrochloride Capsule [Proficient Rx Lp]
  • Remedyrepack Inc.
    Clindamycin Hydrochloride Capsule [Remedyrepack Inc. ]
  • Lannett Company, Inc.
    Clindamycin Hydrochloride Capsule [Lannett Company, Inc.]
  • Aurobindo Pharma Limited
    Clindamycin Hydrochloride Capsule [Aurobindo Pharma Limited]
  • Proficient Rx Lp
    Clindamycin Hydrochloride Capsule [Proficient Rx Lp]
  • Teva Pharmaceuticals Usa Inc
    Clindamycin Hydrochloride Capsule [Teva Pharmaceuticals Usa Inc]
  • Preferred Pharmaceuticals, Inc.
    Clindamycin Hydrochloride Capsule [Preferred Pharmaceuticals, Inc.]
  • Actavis Pharma, Inc.
    Clindamycin Hydrochloride Capsule [Actavis Pharma, Inc.]
  • Cardinal Health
    Clindamycin Hydrochloride Capsule [Cardinal Health]
  • Corepharma, Llc
    Clindamycin Hydrochloride Capsule, Gelatin Coated [Corepharma, Llc]
  • Avpak
    Clindamycin Hydrochloride Capsule [Avpak]
  • Direct Rx
    Clindamycin Hydrochloride Capsule [Direct Rx]
  • Medsource Pharmaceuticals
    Clindamycin Hydrochloride Capsule [Medsource Pharmaceuticals]
  • Direct Rx
    Clindamycin Hydrochloride Capsule [Direct Rx]
  • Proficient Rx Lp
    Clindamycin Hydrochloride Capsule [Proficient Rx Lp]
  • H3 Medical Inc.
    Clindamycin Hydrochloride Powder [H3 Medical Inc.]

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