Dariclox
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Questions & Answers
Side Effects & Adverse Reactions
WARNINGS: Milk taken from animals during treatment and for 48 hours (4 milkings) after the last treatment must not be used for food. Treated animals must not be slaughtered for food purposes within 10 days after the last treatment.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
INDICATIONS: Dariclox is indicated in the treatment of bovine mastitis in lactating cows due to Streptococcus agalactiae and nonpenicillinase-producing Staphylococcus aureus.
Clinical experience indicates that antibiotic efficacy in the treatment of mastitis in lactating cows is directly related to the duration of infection. Therefore, treatment should be instituted as early as possible after detection.
History
There is currently no drug history available for this drug.
Other Information
DESCRIPTION: Dariclox (sodium cloxacillin) is a stable, nonirritating suspension of sodium cloxacillin containing the equivalent of 200 mg of cloxacillin in saturated vegetable oils per disposable syringe. Dariclox is manufactured by a nonsterilizing process.
Cloxacillin is a semisynthetic penicillin derived from the penicillin nucleus, 6-amino-penicillanic acid. Sodium cloxacillin is the monohydrate sodium salt of 5-methyl-3-(o-chlorophenyl)-4-isoxazolyl penicillin.
Sources
Dariclox Manufacturers
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Merck Sharp & Dohme Corp.
![Dariclox (Cloxacillin Sodium) Suspension [Merck Sharp & Dohme Corp.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Dariclox | Merck Sharp & Dohme Corp.
DOSAGE AND ADMINISTRATION: Milk out udder completely. Wash udder and teats thoroughly with warm water containing a suitable dairy antiseptic. Dry thoroughly. Clean and disinfect the teat with alcohol swabs provided in the carton. Remove the syringe tip cover and insert the tip of the syringe into the teat orifice. Express the suspension into the quarter with gentle and continuous pressure. Withdraw the syringe and grasp the end of the teat firmly. Massage the medication up into the milk cistern.
For optimum response the drug should be administered by intramammary infusion in each infected quarter as described above. Treatment should be repeated at 12-hour intervals for a total of 3 doses. The treated quarter should be milked out at the next routine milking.
Each carton contains 12 alcohol swabs to facilitate proper cleaning and disinfecting of the teat orifice.
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