Dexpanthenol
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Questions & Answers
Side Effects & Adverse Reactions
There have been rare instances of allergic reactions of unknown cause during the concomitant use of Dexpanthenol Injection with drugs such as antibiotics, narcotics and barbiturates.
Administration of Dexpanthenol Injection directly into the vein is not advised (See Dosage and Administration).
Dexpanthenol Injection should not be administered within one hour of succinylcholine.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Prophylactic use immediately after major abdominal surgery to minimize the possibility of paralytic ileus. Intestinal atony causing abdominal distention; postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility; paralytic ileus.
History
There is currently no drug history available for this drug.
Other Information
Dexpanthenol is a derivative of pantothenic acid, a B complex vitamin. Dexpanthenol Injection is a sterile, nonpyrogenic, aqueous solution indicated for use as a gastrointestinal stimulant. The chemical name is D-(+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethybutylamide. The structural formula is:
Each mL contains Dexpanthenol 250 mg in Water for Injection q.s. pH (range 4 - 7) may be adjusted with Sodium Citrate and/or Citric Acid.
Sources
Dexpanthenol Manufacturers
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American Regent, Inc.
![Dexpanthenol Injection, Solution [American Regent, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Dexpanthenol | American Regent, Inc.
Prevention of post-operative adynamic ileus: 250 mg (1 mL) or 500 mg (2 mL) intramuscularly. Repeat in 2 hours and then every 6 hours until all danger of adynamic ileus has passed.
Treatment of adynamic ileus: 500 mg (2 mL) intramuscularly. Repeat in 2 hours and then every 6 hours as needed.
Intravenous administration: Dexpanthenol Injection 2 mL (500 mg) may be mixed with bulk I.V. solutions such as glucose or Lactated Ringer’s and slowly infused intravenously.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
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Med-pharmex, Inc
Dexpanthenol | Med-pharmex, Inc
DOSAGE AND ADMINISTRATION:
Dogs and Cats: 25 mg per 5 lbs. body weight intramuscularly.
Horses: Initial dose 10 cc intravenously or intramuscularly.
![Dexpanthenol Injection, Solution [Med-pharmex, Inc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=a6d5c3fb-2e99-4e02-9442-af8ff63e22e9&name=DexpanthenolInjection100mL.jpg)
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