Dicyclomine Hydrochloride

Dicyclomine Hydrochloride

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Questions & Answers

Side Effects & Adverse Reactions

In the presence of a high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating). If symptoms occur, the drug should be discontinued and supportive measures instituted.

Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance, treatment with this drug would be inappropriate and possibly harmful.

Dicyclomine hydrochloride may produce drowsiness or blurred vision. The patient should be warned not to engage in activities requiring mental alertness, such as operating a motor vehicle or other machinery or performing hazardous work while taking this drug.

Psychosis has been reported in sensitive individuals given anticholinergic drugs. CNS signs and symptoms include confusion, disorientation, short-term memory loss, hallucinations, dysarthria, ataxia, coma, euphoria, decreased anxiety, fatigue, insomnia, agitation and mannerisms and inappropriate affect.

These CNS signs and symptoms usually resolve within 12 to 24 hours after discontinuation of the drug.

There are reports that administration of dicyclomine hydrochloride syrup to infants has been followed by serious respiratory symptoms (dyspnea, shortness of breath, breathlessness, respiratory collapse, apnea, asphyxia), seizures, syncope, pulse rate fluctuations, muscular hypotonia, and coma. Death has been reported. No causal relationship between these effects observed in infants and dicyclomine administration has been established. DICYCLOMINE HYDROCHLORIDE IS CONTRAINDICATED IN INFANTS LESS THAN 6 MONTHS OF AGE AND IN NURSING MOTHERS. (See CONTRAINDICATIONS and PRECAUTIONS: Nursing Mothers and Pediatric Use.)

Safety and efficacy of dicyclomine hydrochloride in pediatric patients have not been established.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

For the treatment of functional bowel/irritable bowel syndrome.

History

There is currently no drug history available for this drug.

Other Information

Dicyclomine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent.

Chemically, dicyclomine hydrochloride is [bicyclohexyl]-1-carboxylic acid, 2-(diethylamino) ethyl ester, hydrochloride with the following structural formula, molecular weight, and molecular formula:

Structural Formula

C19H35NO2 • HCl              M.W. 345.96

C19H35NO2 • HCl              M.W. 345.96

Dicyclomine hydrochloride occurs as a fine, white, crystalline, practically odorless powder with a bitter taste. It is soluble in water, freely soluble in alcohol and chloroform, and very slightly soluble in ether.

Dicyclomine hydrochloride tablets, for oral administration, contain 20 mg of dicyclomine hydrochloride, USP. In addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, FD&C Blue No.1 Lake, magnesium stearate, microcrystalline cellulose, pregelatinized starch, and sodium lauryl sulfate.

Dicyclomine Hydrochloride Manufacturers


  • Preferred Pharmaceuticals Inc.
    Dicyclomine Hydrochloride Tablet [Preferred Pharmaceuticals Inc.]
  • Direct Rx
    Dicyclomine Hydrochloride Tablet [Direct Rx]
  • Blenheim Pharmacal, Inc.
    Dicyclomine Hydrochloride Tablet [Blenheim Pharmacal, Inc.]
  • A-s Medication Solutions Llc
    Dicyclomine Hydrochloride Tablet Dicyclomine Hydrochloride Capsule [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Dicyclomine Hydrochloride Capsule [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Dicyclomine Hydrochloride Capsule [A-s Medication Solutions Llc]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Tablet [Remedyrepack Inc. ]
  • St. Mary’s Medical Park Pharmacy
    Dicyclomine Hydrochloride Tablet [St. Mary’s Medical Park Pharmacy]
  • Mylan Pharmaceuticals Inc.
    Dicyclomine Hydrochloride Tablet [Mylan Pharmaceuticals Inc.]
  • Stat Rx Usa
    Dicyclomine Hydrochloride Capsule [Stat Rx Usa]
  • State Of Florida Doh Central Pharmacy
    Dicyclomine Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • Physicians Total Care, Inc.
    Dicyclomine Hydrochloride Capsule [Physicians Total Care, Inc.]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride (Dicyclomine ) Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride (Dicyclomine Hydrochloride) Capsule [Remedyrepack Inc. ]
  • Physicians Total Care, Inc.
    Dicyclomine Hydrochloride Tablet [Physicians Total Care, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Dicyclomine Hydrochloride Capsule [Pd-rx Pharmaceuticals, Inc.]
  • Rebel Distributors Corp
    Dicyclomine Hydrochloride Tablet [Rebel Distributors Corp]
  • Life Line Home Care Services, Inc.
    Dicyclomine Hydrochloride Tablet [Life Line Home Care Services, Inc.]
  • West-ward Pharmaceutical Corp
    Dicyclomine Hydrochloride Capsule Dicyclomine (Dicyclomine Hydrochloride) Tablet [West-ward Pharmaceutical Corp]
  • Lannett Company, Inc.
    Dicyclomine Hydrochloride Tablet Dicyclomine Hydrochloride Capsule [Lannett Company, Inc.]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Rebel Distributors Corp
    Dicyclomine Hydrochloride Capsule [Rebel Distributors Corp]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Capsule [Remedyrepack Inc. ]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Dicyclomine Hydrochloride Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Dicyclomine Hydrochloride Capsule [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Unit Dose Services
    Dicyclomine Hydrochloride Capsule [Unit Dose Services]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Capsule [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Dicyclomine Hydrochloride Capsule [Lake Erie Medical Dba Quality Care Products Llc]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Capsule [Remedyrepack Inc. ]
  • A-s Medication Solutions Llc
    Dicyclomine Hydrochloride Capsule [A-s Medication Solutions Llc]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Capsule [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Dicyclomine Hydrochloride Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Capsule [Remedyrepack Inc. ]
  • Dispensing Solutions, Inc.
    Dicyclomine Hydrochloride Capsule [Dispensing Solutions, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Dicyclomine Hydrochloride Capsule [Preferred Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc
    Dicyclomine Hydrochloride Capsule [Preferred Pharmaceuticals, Inc]
  • Aidarex Pharmaceuticals Llc
    Dicyclomine Hydrochloride Tablet Dicyclomine Hydrochloride Capsule [Aidarex Pharmaceuticals Llc]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Liberty Pharmaceuticals, Inc.
    Dicyclomine Hydrochloride Capsule [Liberty Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Dicyclomine Hydrochloride Tablet [Preferred Pharmaceuticals, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Dicyclomine Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • State Of Florida Doh Central Pharmacy
    Dicyclomine Hydrochloride Capsule [State Of Florida Doh Central Pharmacy]
  • Remedyrepack Inc.
    Dicyclomine Hydrochloride Capsule [Remedyrepack Inc. ]
  • Bryant Ranch Prepack
    Dicyclomine Hydrochloride Capsule [Bryant Ranch Prepack]
  • Tya Pharmaceuticals
    Dicyclomine Hydrochloride Capsule [Tya Pharmaceuticals]
  • Clinical Solutions Wholesale
    Dicyclomine Hydrochloride Tablet [Clinical Solutions Wholesale]
  • Proficient Rx Lp
    Dicyclomine Hydrochloride Tablet Dicyclomine Hydrochloride Capsule [Proficient Rx Lp]

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