Eprinex Pour-on For Cattle
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Questions & Answers
Side Effects & Adverse Reactions
Keep this and all drugs out of the reach of children.
NOT FOR USE IN HUMANS.
As with any topical medication intended for treatment of animals, skin contact should be avoided. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water. The material safety data sheet (MSDS) contains more detailed occupational safety information.
To report adverse effects, obtain an MSDS or for assistance, contact Merial at 1-888-637-4251.
Legal Issues
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FDA Safety Alerts
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Manufacturer Warnings
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FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
There is currently no usage information available for this product. We apologize for any inconvenience.
History
There is currently no drug history available for this drug.
Other Information
EPRINEX Pour-On delivers effective internal and external parasite control in one application. Discovered and developed by scientists from Merck Research Laboratories, EPRINEX Pour-On contains eprinomectin, a unique avermectin. Its broad-spectrum efficacy in a weatherproof formulation, margin of safety, zero slaughter withdrawal and zero milk discard, make it a convenient product for parasite control in beef and dairy cattle, including lactating dairy cattle.
Eprinomectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
Sources
Eprinex Pour-on For Cattle Manufacturers
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Merial Limited
![Eprinex Pour-on For Cattle (Eprinomectin) Solution [Merial Limited]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Eprinex Pour-on For Cattle | Merial Limited
The product is formulated only for external application to beef and dairy cattle. The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tailhead.
Squeeze-Measure-Pour System (250 mL/8.5 fl oz Bottle with 25 mL Metering Cup)Attach the metering cup to the bottle.
Set the dose by turning the top section of the cup to align the correct body weight with the pointer on the knurled cap. When body weight is between markings, use the higher setting.
Hold the bottle upright and squeeze it to deliver a slight excess of the required dose as indicated by the calibration lines. By releasing the pressure, the dose automatically adjusts to the correct level. The off (STOP) position will close the system between dosing. Tilt the bottle to deliver the dose.
Squeeze-Measure-Pour System (1 L/33.8 fl oz Bottle with 50 mL Metering Cup)Attach the metering cup to the bottle.
Set the dose by turning the top section of the cup to align the correct body weight with the pointer on the knurled cap. When body weight is between markings, use the higher setting.
Hold the bottle upright and squeeze it to deliver a slight excess of the required dose as indicated by the calibration lines.
By releasing the pressure, the dose automatically adjusts to the correct level. When a 220 lb (10 mL) or 330 lb (15 mL) dose is required, turn the pointer to "STOP" before delivering the dose. The off (STOP) position will close the system between dosing. Tilt the bottle to deliver the dose.
Collapsible Pack (2.5 L/84.5 fl oz and 5 L/169 fl oz Packs)Connect the dosing applicator and draw-off tubing to the collapsible pack as follows:
Attach the open end of the draw-off tubing to an appropriate dosing applicator. Attach draw-off tubing to the cap with the stem that is included in the pack. Replace the shipping cap with the cap having the draw-off tubing.
Gently prime the dosing applicator, checking for leaks. Follow the dosing applicator manufacturer's directions for adjusting the dose and proper use and maintenance of the dosing applicator and draw-off tubing.
20 Liter Pack (20 L/676 fl oz Pack)Connect the dosing applicator and draw-off tubing to the container as follows:
Attach the open end of the draw-off tubing to an appropriate dosing applicator. Attach draw-off tubing to the cap with the stem. Replace the shipping cap with the cap having the draw-off tubing.
Gently prime the dosing applicator, checking for leaks. Follow the dosing applicator manufacturer's directions for adjusting the dose and proper use and maintenance of the dosing applicator and draw-off tubing.
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