Erythromycin

Erythromycin

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Questions & Answers

Side Effects & Adverse Reactions

Pseudomembranous colitis has been reported with nearly all antibacterial agents, including erythromycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.

Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is one primary cause of ``antibiotic-associated colitis′′.

After the diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone.

In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation and treatment with an antibacterial drug clinically effective against C. difficile colitis.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Erythromycin pledgets, USP are indicated for the topical treatment of acne vulgaris.

History

There is currently no drug history available for this drug.

Other Information

Erythromycin Pledgets, USP contains erythromycin ((3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-⌊-ribo-hexopyranosyl)-oxy]-14-ethyl-7,12,13-trihydroxy 3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-d-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione), for topical dermatologic use. Erythromycin is a macrolide antibiotic produced from a strain of Saccharopolyspora erythraea (formerly Streptomyces erythreus).

It is a base and readily forms salts with acids. Chemically, erythromycin is C37H67NO13. It has the following structural formula:

Image from Drug Label Content

Erythromycin has the molecular weight of 733.94

It is a white powder, is freely soluble in alcohols, acetone, chloroform, acetonitrile, ethyl acetate, and moderately soluble in ether, ethylene dichloride and amyl acetate. Erythromycin pledgets, USP are absorbent pads impregnated with Erythromycin Topical Solution 2%. Each pledget contains 1 mL of Erythromycin Topical Solution 2% and each 1 mL of Erythromycin Topical Solution 2% contains 20 mg of erythromycin base in a vehicle consisting of alcohol (71.5% v/v) and propylene glycol. May contain anhydrous citric acid and/or alcohol to adjust pH.

Erythromycin Manufacturers


  • E. Fougera & Co.
    Erythromycin (Erythromycin) Solution [E. Fougera & Co.]
  • Stat Rx Usa
    Erythromycin Capsule, Delayed Release [Stat Rx Usa]
  • Stat Rx Usa Llc
    Erythromycin Tablet, Film Coated [Stat Rx Usa Llc]
  • Kaiser Foundation Hospitals
    Erythromycin Capsule, Delayed Release [Kaiser Foundation Hospitals]
  • Midlothian Laboratories
    Erythromycin Capsule, Delayed Release Pellets [Midlothian Laboratories]
  • A-s Medication Solutions Llc
    Erythromycin Capsule, Delayed Release [A-s Medication Solutions Llc]
  • Arbor Pharmaceuticals, Inc.
    Erythromycin Capsule, Delayed Release [Arbor Pharmaceuticals, Inc.]
  • Arbor Pharmaceuticals, Inc.
    Erythromycin Tablet, Film Coated [Arbor Pharmaceuticals, Inc.]

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