Extra Strength Non-aspirin Pain Reliever

Extra Strength Non-aspirin Pain Reliever Manufacturers

• Stephen L. Lafrance Pharmacy, Inc.
  

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  Extra Strength Non-aspirin Pain Reliever | Bimeda Inc, Division Of Cross Vetpharm Group

  

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  DOSAGE AND TREATMENT: Pyrantel Paste (pyrantel pamoate) is to be adminitered as a single oral dose of 3 milligrams pytantel base per pound of body weight. The syringe has four weight mark increments. Each weight mark indicated the recommended dose for 300 pounds of body weight.

  DOSAGE

  Body Weight Range Quantity mg Pyrantel Base                      up to 300 lb                 ¼ syringe                            900 mg                     301 to 600lb                 ½ syringe                           1800 mg                    601 to 900 lb                 ¾ syringe                           2700 mg                    901 to 1200 lb               1 full syringe                           3600 mg

  NOTE: Position ring-gauge over appropriate mark on plunger.

  For maximum control of parasitism it is recommended that foals(2-8 months of age) be dosed every 4 weeks. To minimize the potential source of infection that the mare may pose to the foal, the mare should be treated 1 month prior to anticipated foaling date by re-treating 10 days to 2 weeks after birth of the foal. Horses and ponies over 8 months of age should be routinely dosed every 6 weeks.

  It is recommended that severely debilitated animals not be treated with this preparation.

  ADMINISTRATION:

  After removing the cap, the paste should be deposited on the dorsum of the tongue. Introduce the nozzle end of the syringe at the corner of the mouth. Direct the syringe backward and depress the plunger to deposit the paste onto the tongue. Given in this manner, it is unlikely that rejection of the paste will occur.

  Raising the horses head sometimes assists in the swallowing process. When only part of the paste has been used, replace the cap on the syringe nozzle.

  EFFICACY: Critical (worm count) studies in horses demonstrated that pyrantel pamoate administered at the recommended dosage was efficacious against mature infection of Strongylus vulgaris (>90%), S.edentatus (69%), S.equinus (>90%), Oxyuris equi (81%), Parascaris equorum (>90%), and small strongyles (>90%).

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• Stephen L. Lafrance Pharmacy, Inc.
  

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  Extra Strength Non-aspirin Pain Reliever | Fresenius Kabi Usa, Llc

  

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  Treatment

  The usual adult dosage is 1 or 2 grams of Cefotetan for Injection, USP administered intravenously or intramuscularly.  Proper dosage and route of administration should be determined by the condition of the patient, severity of the infection, and susceptibility of the causative organism.

  
  General Guidelines For Dosage of Cefotetan for Injection, USP
  Type of Infection
  Daily Dose
  Frequency and Route
  Urinary Tract
  1 to 4 grams
  500 mg every 12 hours IV or IM
  1 or 2 g every 24 hours IV or IM
  1 or 2 g every 12 hours IV or IM
  Skin & Skin Structure
       Mild - Moderatea
   
       Severe
   
  2 grams
   
  4 grams
   
  2 g every 24 hours IV
  1 g every 12 hours IV or IM
  2 g every 12 hours IV
  Other Sites
  2 to 4 grams
  1 or 2 g every 12 hours IV or IM
  Severe
  4 grams
  2 g every 12 hours IV
  Life-Threatening
  6 gramsb
  3 g every 12 hours IV
  a Klebsiella pneumoniae skin and skin structure infections should be treated with 1 or
    2 grams every 12 hours IV or IM.
  b Maximum daily dosage should not exceed 6 grams.
  
  
  

  If Chlamydia trachomatis is a suspected pathogen in gynecologic infections, appropriate antichlamydial coverage should be added, since cefotetan has no activity against this organism.

  Prophylaxis

  To prevent postoperative infection in clean contaminated or potentially contaminated surgery in adults, the recommended dosage is 1 or 2 g of Cefotetan for Injection, USP administered once, intravenously, 30 to 60 minutes prior to surgery.  In patients undergoing cesarean section, the dose should be administered as soon as the umbilical cord is clamped.

  Impaired Renal Function

  When renal function is impaired, a reduced dosage schedule must be employed.  The following dosage guidelines may be used.

  
   
  DOSAGE GUIDELINES FOR PATIENTS WITH IMPAIRED RENAL FUNCTION
   
  
   
  Creatinine Clearance
   
  mL/min
  
  
   
  Dose
   
  
   
  Frequency
   
  
   
  > 30
   
  
   
  Usual Recommended Dosage*
   
  
   
  Every 12 hours
   
  
   
  10 to 30
   
  
   
  Usual Recommended Dosage*
   
  
   
  Every 24 hours
   
  
   
  < 10
   
  
   
  Usual Recommended Dosage*
   
  
   
  Every 48 hours
   
  
  

  * Dose determined by the type and severity of infection, and susceptibility of the causative organism.

  
  

  Alternatively, the dosing interval may remain constant at 12 hour intervals, but the dose reduced to one-half the usual recommended dose for patients with a creatinine clearance of 10 to 30 mL/min, and one-quarter the usual recommended dose for patients with a creatinine clearance of less than 10 mL/min.

  
  

  When only serum creatinine levels are available, creatinine clearance may be calculated from the following formula.  The serum creatinine level should represent a steady state of renal function.

  
  
  

  Males:                 Weight (kg) x (140 - age)       

  
  

                        72 x serum creatinine (mg/100 mL)

  
  

  Females:   0.85 x value for males

  
  
  

  Cefotetan is dialyzable and it is recommended that for patients undergoing intermittent hemodialysis, one-quarter of the usual recommended dose be given every 24 hours on days between dialysis and one-half the usual recommended dose on the day of dialysis.

  Preparation of Solution

  For Intravenous Use

  Reconstitute with Sterile Water for Injection.  Shake to dissolve and let stand until clear.

  
  Vial Size
   
  
   
  Amount of
   
  Diluent
  
  Added (mL)
  
  
   
  Approximate Withdrawable
   
  Vol (mL)
  
  
   
  Approximate
   
  Average Concentration (mg/mL)
  
  
   
  1 gram
   
  
   
  10
   
  
   
  10.5
   
  
   
  95
   
  
   
  2 gram
   
  
   
  10 to 20
   
  
   
  11 to 21
   
  
   
  182 to 95
   
  
  

  
  For Intramuscular Use

  Reconstitute with Sterile Water for Injection; Bacteriostatic Water for Injection; Sodium Chloride Injection 0.9%, USP; 0.5% Lidocaine HCl; or 1% Lidocaine HCl.  Shake to dissolve and let stand until clear.

  
  Vial Size
   
  
   
  Amount of
   
  Diluent
  
  Added (mL)
  
  
   
  Approximate Withdrawable
   
  Vol (mL)
  
  
   
  Approximate
   
  Average Concentration
  
  (mg/mL)
  
  
   
  1 gram
   
  
   
  2
   
  
   
  2.5
   
  
   
  400
   
  
   
  2 gram
   
  
   
  3
   
  
   
  4
   
  
   
  500
   
  
  Intravenous Administration

  The intravenous route is preferable for patients with bacteremia, bacterial septicemia, or other severe or life-threatening infections, or for patients who may be poor risks because of lowered resistance resulting from such debilitating conditions as malnutrition, trauma, surgery, diabetes, heart failure, or malignancy, particularly if shock is present or impending.

  For intermittent intravenous administration, a solution containing 1 gram or 2 grams of Cefotetan for Injection, USP in Sterile Water for Injection can be injected over a period of three to five minutes.  Using an infusion system, the solution may also be given over a longer period of time through the tubing system by which the patient may be receiving other intravenous solutions.  Butterfly® or scalp vein-type needles are preferred for this type of infusion.  However, during infusion of the solution containing Cefotetan for Injection, USP, it is advisable to discontinue temporarily the administration of other solutions at the same site.

  NOTE: Solutions of cefotetan must not be admixed with solutions containing aminoglycosides.  If cefotetan and aminoglycosides are to be administered to the same patient, they must be administered separately and not as a mixed injection.

  Intramuscular Administration

  As with all intramuscular preparations, Cefotetan for Injection, USP should be injected well within the body of a relatively large muscle such as the upper outer quadrant of the buttock (i.e., gluteus maximus); aspiration is necessary to avoid inadvertent injection into a blood vessel.

  Compatibility and Stability

  Frozen samples should be thawed at room temperature before use.  After the periods mentioned below, any unused solutions or frozen material should be discarded.  DO NOT REFREEZE.

  NOTE:  Solutions of Cefotetan for Injection, USP must not be admixed with solutions containing aminoglycosides.  If Cefotetan for Injection, USP and aminoglycosides are to be administered to the same patient, they must be administered separately and not as a mixed injection.  DO NOT ADD SUPPLEMENTARY MEDICATION.

  Cefotetan for Injection, USP reconstituted as described above (see DOSAGE AND ADMINISTRATION, Preparation of Solution) maintains satisfactory potency for 24 hours at room temperature (25°C/77°F), for 96 hours under refrigeration (5°C/41°F), and for at least 1 week in the frozen state (-20°C/-4°F).  After reconstitution and subsequent storage in disposable glass or plastic syringes, Cefotetan for Injection, USP is stable for 24 hours at room temperature and 96 hours under refrigeration.

  NOTE: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

  Treatment

  The usual adult dosage is 1 or 2 grams of Cefotetan for Injection, USP administered intravenously or intramuscularly.  Proper dosage and route of administration should be determined by the condition of the patient, severity of the infection, and susceptibility of the causative organism.

  
  General Guidelines For Dosage of Cefotetan for Injection, USP
  Type of Infection
  Daily Dose
  Frequency and Route
  Urinary Tract
  1 to 4 grams
  500 mg every 12 hours IV or IM
  1 or 2 g every 24 hours IV or IM
  1 or 2 g every 12 hours IV or IM
  Skin & Skin Structure
       Mild - Moderatea
   
       Severe
   
  2 grams
   
  4 grams
   
  2 g every 24 hours IV
  1 g every 12 hours IV or IM
  2 g every 12 hours IV
  Other Sites
  2 to 4 grams
  1 or 2 g every 12 hours IV or IM
  Severe
  4 grams
  2 g every 12 hours IV
  Life-Threatening
  6 gramsb
  3 g every 12 hours IV
  a Klebsiella pneumoniae skin and skin structure infections should be treated with 1 or
    2 grams every 12 hours IV or IM.
  b Maximum daily dosage should not exceed 6 grams.
  
  
  

  If Chlamydia trachomatis is a suspected pathogen in gynecologic infections, appropriate antichlamydial coverage should be added, since cefotetan has no activity against this organism.

  Prophylaxis

  To prevent postoperative infection in clean contaminated or potentially contaminated surgery in adults, the recommended dosage is 1 or 2 g of Cefotetan for Injection, USP administered once, intravenously, 30 to 60 minutes prior to surgery.  In patients undergoing cesarean section, the dose should be administered as soon as the umbilical cord is clamped.

  Impaired Renal Function

  When renal function is impaired, a reduced dosage schedule must be employed.  The following dosage guidelines may be used.

  
   
  DOSAGE GUIDELINES FOR PATIENTS WITH IMPAIRED RENAL FUNCTION
   
  
   
  Creatinine Clearance
   
  mL/min
  
  
   
  Dose
   
  
   
  Frequency
   
  
   
  > 30
   
  
   
  Usual Recommended Dosage*
   
  
   
  Every 12 hours
   
  
   
  10 to 30
   
  
   
  Usual Recommended Dosage*
   
  
   
  Every 24 hours
   
  
   
  < 10
   
  
   
  Usual Recommended Dosage*
   
  
   
  Every 48 hours
   
  
  

  * Dose determined by the type and severity of infection, and susceptibility of the causative organism.

  
  

  Alternatively, the dosing interval may remain constant at 12 hour intervals, but the dose reduced to one-half the usual recommended dose for patients with a creatinine clearance of 10 to 30 mL/min, and one-quarter the usual recommended dose for patients with a creatinine clearance of less than 10 mL/min.

  
  

  When only serum creatinine levels are available, creatinine clearance may be calculated from the following formula.  The serum creatinine level should represent a steady state of renal function.

  
  
  

  Males:                 Weight (kg) x (140 - age)       

  
  

                        72 x serum creatinine (mg/100 mL)

  
  

  Females:   0.85 x value for males

  
  
  

  Cefotetan is dialyzable and it is recommended that for patients undergoing intermittent hemodialysis, one-quarter of the usual recommended dose be given every 24 hours on days between dialysis and one-half the usual recommended dose on the day of dialysis.

  Preparation of Solution

  For Intravenous Use

  Reconstitute with Sterile Water for Injection.  Shake to dissolve and let stand until clear.

  
  Vial Size
   
  
   
  Amount of
   
  Diluent
  
  Added (mL)
  
  
   
  Approximate Withdrawable
   
  Vol (mL)
  
  
   
  Approximate
   
  Average Concentration (mg/mL)
  
  
   
  1 gram
   
  
   
  10
   
  
   
  10.5
   
  
   
  95
   
  
   
  2 gram
   
  
   
  10 to 20
   
  
   
  11 to 21
   
  
   
  182 to 95
   
  
  

  
  For Intramuscular Use

  Reconstitute with Sterile Water for Injection; Bacteriostatic Water for Injection; Sodium Chloride Injection 0.9%, USP; 0.5% Lidocaine HCl; or 1% Lidocaine HCl.  Shake to dissolve and let stand until clear.

  
  Vial Size
   
  
   
  Amount of
   
  Diluent
  
  Added (mL)
  
  
   
  Approximate Withdrawable
   
  Vol (mL)
  
  
   
  Approximate
   
  Average Concentration
  
  (mg/mL)
  
  
   
  1 gram
   
  
   
  2
   
  
   
  2.5
   
  
   
  400
   
  
   
  2 gram
   
  
   
  3
   
  
   
  4
   
  
   
  500
   
  
  Intravenous Administration

  The intravenous route is preferable for patients with bacteremia, bacterial septicemia, or other severe or life-threatening infections, or for patients who may be poor risks because of lowered resistance resulting from such debilitating conditions as malnutrition, trauma, surgery, diabetes, heart failure, or malignancy, particularly if shock is present or impending.

  For intermittent intravenous administration, a solution containing 1 gram or 2 grams of Cefotetan for Injection, USP in Sterile Water for Injection can be injected over a period of three to five minutes.  Using an infusion system, the solution may also be given over a longer period of time through the tubing system by which the patient may be receiving other intravenous solutions.  Butterfly® or scalp vein-type needles are preferred for this type of infusion.  However, during infusion of the solution containing Cefotetan for Injection, USP, it is advisable to discontinue temporarily the administration of other solutions at the same site.

  NOTE: Solutions of cefotetan must not be admixed with solutions containing aminoglycosides.  If cefotetan and aminoglycosides are to be administered to the same patient, they must be administered separately and not as a mixed injection.

  Intramuscular Administration

  As with all intramuscular preparations, Cefotetan for Injection, USP should be injected well within the body of a relatively large muscle such as the upper outer quadrant of the buttock (i.e., gluteus maximus); aspiration is necessary to avoid inadvertent injection into a blood vessel.

  Compatibility and Stability

  Frozen samples should be thawed at room temperature before use.  After the periods mentioned below, any unused solutions or frozen material should be discarded.  DO NOT REFREEZE.

  NOTE:  Solutions of Cefotetan for Injection, USP must not be admixed with solutions containing aminoglycosides.  If Cefotetan for Injection, USP and aminoglycosides are to be administered to the same patient, they must be administered separately and not as a mixed injection.  DO NOT ADD SUPPLEMENTARY MEDICATION.

  Cefotetan for Injection, USP reconstituted as described above (see DOSAGE AND ADMINISTRATION, Preparation of Solution) maintains satisfactory potency for 24 hours at room temperature (25°C/77°F), for 96 hours under refrigeration (5°C/41°F), and for at least 1 week in the frozen state (-20°C/-4°F).  After reconstitution and subsequent storage in disposable glass or plastic syringes, Cefotetan for Injection, USP is stable for 24 hours at room temperature and 96 hours under refrigeration.

  NOTE: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

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