Furosemide

Furosemide

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Side Effects & Adverse Reactions

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Legal Issues

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FDA Safety Alerts

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Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.

1.1 Intra-abdominal Infections

Appendicitis (complicated by rupture or abscess) and peritonitis caused by β-lactamase producing isolates of Escherichia coli or the following members of the Bacteroides fragilis group: B. fragilis, B. ovatus, B. thetaiotaomicron, or B. vulgatus. The individual members of this group were studied in fewer than 10 cases.

1.2 Skin and Skin Structure Infections

Uncomplicated and complicated skin and skin structure infections, including cellulitis, cutaneous abscesses and ischemic/diabetic foot infections caused by β-lactamase producing isolates of Staphylococcus aureus.

1.3 Female Pelvic Infections

Postpartum endometritis or pelvic inflammatory disease caused by β-lactamase producing isolates of Escherichia coli.

1.4 Community-acquired Pneumonia

Community-acquired pneumonia (moderate severity only) caused by β-lactamase producing isolates of Haemophilus influenzae.

1.5 Nosocomial Pneumonia

Nosocomial pneumonia (moderate to severe) caused by β-lactamase producing isolates of Staphylococcus aureus and by piperacillin/tazobactam-susceptible Acinetobacter baumannii, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa (Nosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycoside) [see Dosage and Administration (2)].

To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZOSYN and other antibacterial drugs, ZOSYN should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

History

There is currently no drug history available for this drug.

Other Information

ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration.

Piperacillin sodium is derived from D(-)-α-aminobenzyl-penicillin. The chemical name of piperacillin sodium is sodium (2S,5R,6R)-6-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. The chemical formula is C23H26N5NaO7S and the molecular weight is 539.5. The chemical structure of piperacillin sodium is:

Chemical Structure

Tazobactam sodium, a derivative of the penicillin nucleus, is a penicillanic acid sulfone. Its chemical name is sodium (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate-4,4-dioxide. The chemical formula is C10H11N4NaO5S and the molecular weight is 322.3. The chemical structure of tazobactam sodium is:

Chemical Structure

ZOSYN (piperacillin and tazobactam) for Injection, is a white to off-white sterile, cryodesiccated powder consisting of piperacillin and tazobactam as their sodium salts packaged in glass vials. The formulation also contains edetate disodium dihydrate (EDTA) and sodium citrate.

Each ZOSYN 2.25 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. The product also contains 0.5 mg of EDTA per vial.

Each ZOSYN 3.375 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam. The product also contains 0.75 mg of EDTA per vial.

Each ZOSYN 4.5 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 4 grams of piperacillin and tazobactam sodium equivalent to 0.5 g of tazobactam. The product also contains 1 mg of EDTA per vial.

ZOSYN contains a total of 2.79 mEq (64 mg) of sodium (Na+) per gram of piperacillin in the combination product.

Furosemide Manufacturers


  • Proficient Rx Lp
    Furosemide Tablet [Proficient Rx Lp]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Heritage Pharmaceuticals Inc.
    Furosemide Injection, Solution [Heritage Pharmaceuticals Inc.]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Injection, Solution [Remedyrepack Inc. ]
  • A-s Medication Solutions Llc
    Furosemide Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Furosemide Tablet [A-s Medication Solutions Llc]
  • Direct Rx
    Furosemide Tablet [Direct Rx]
  • Cardinal Health
    Furosemide Injection, Solution [Cardinal Health]
  • Furosemide (Furosemide) Tablet Furosemide (Furosemide) Solution
  • Watson Labs
    Furosemide (Furosemide) Tablet [Watson Labs]
  • Mckesson Packaging Services Business Unit Of Mckesson Corporation
    Furosemide Injection [Mckesson Packaging Services Business Unit Of Mckesson Corporation]
  • Contract Pharmacy Services-pa
    Furosemide Tablet [Contract Pharmacy Services-pa]
  • State Of Florida Doh Central Pharmacy
    Furosemide Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
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  • General Injectables & Vaccines, Inc
    Furosemide Injection, Solution [General Injectables & Vaccines, Inc]
  • General Injectables & Vaccines, Inc
    Furosemide Injection, Solution [General Injectables & Vaccines, Inc]
  • Physicians Total Care, Inc.
    Furosemide Tablet [Physicians Total Care, Inc.]
  • Remedyrepack Inc.
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  • Contract Pharmacy Services-pa
    Furosemide Tablet [Contract Pharmacy Services-pa]
  • Rebel Distributors Corp
    Furosemide Injection [Rebel Distributors Corp]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Mckesson Packaging Services Business Unit Of Mckesson Corporation
    Furosemide Tablet [Mckesson Packaging Services Business Unit Of Mckesson Corporation]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Redpharm Drug Inc.
    Furosemide Tablet [Redpharm Drug Inc.]
  • Unit Dose Services
    Furosemide Tablet [Unit Dose Services]
  • Unit Dose Services
    Furosemide Tablet [Unit Dose Services]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Medvantx, Inc.
    Furosemide Tablet [Medvantx, Inc.]
  • Mckesson Packaging Services A Business Unit Of Mckesson Corporation
    Furosemide Tablet [Mckesson Packaging Services A Business Unit Of Mckesson Corporation]
  • Mckesson Contract Packaging
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  • Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
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  • Pd-rx Pharmaceuticals, Inc.
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  • Rebel Distirbutors Corp
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  • Physicians Total Care, Inc.
    Furosemide Injection [Physicians Total Care, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Furosemide Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Medvantx, Inc.
    Furosemide Tablet [Medvantx, Inc.]
  • Cardinal Health
    Furosemide Injection [Cardinal Health]
  • Qualitest Pharmaceuticals
    Furosemide Tablet [Qualitest Pharmaceuticals]
  • Major Pharmaceuticals
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  • Sandoz Inc
    Furosemide Tablet [Sandoz Inc]
  • Excellium Pharmaceutical Inc.
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  • App Pharmaceuticals, Llc
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    Furosemide Tablet [Stat Rx Usa Llc]
  • Dava Pharmaceuticals, Inc.
    Furosemide Tablet [Dava Pharmaceuticals, Inc.]
  • Roxane Laboratories, Inc
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  • Pd-rx Pharmaceuticals, Inc.
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  • Pd-rx Pharmaceuticals, Inc.
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  • Remedyrepack Inc.
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  • Remedyrepack Inc.
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  • Preferred Pharmaceuticals, Inc.
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  • Ingenus Pharmaceuticals, Llc
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  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Cardinal Health
    Furosemide Injection, Solution [Cardinal Health]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Furosemide Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
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  • Cardinal Health
    Furosemide Injection, Solution [Cardinal Health]
  • Remedyrepack Inc.
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  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • A-s Medication Solutions Llc
    Furosemide (Furosemide) Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
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  • General Injectables & Vaccines, Inc.
    Furosemide Injection, Solution [General Injectables & Vaccines, Inc.]
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  • Lake Erie Medical Dba Quality Care Products Llc
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  • Clinical Solutions Wholesale
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  • St Marys Medical Park Pharmacy
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  • Remedyrepack Inc.
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  • Cardinal Health
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  • Hospira, Inc.
    Furosemide Injection, Solution [Hospira, Inc.]
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    Furosemide Tablet [Remedyrepack Inc. ]
  • New Horizon Rx Group, Llc
    Furosemide Tablet [New Horizon Rx Group, Llc]
  • Aidarex Pharmaceuticals Llc
    Furosemide Tablet [Aidarex Pharmaceuticals Llc]
  • American Health Packaging
    Furosemide Tablet [American Health Packaging]
  • Blenheim Pharmacal, Inc.
    Furosemide Tablet [Blenheim Pharmacal, Inc.]
  • Clipper Distributing Company, Llc.
    Furosemide Injection [Clipper Distributing Company, Llc.]
  • Vedco, Inc.
    Furosemide Injection [Vedco, Inc.]
  • Ranbaxy Pharmaceuticals Inc.
    Furosemide Tablet [Ranbaxy Pharmaceuticals Inc.]
  • State Of Florida Doh Central Pharmacy
    Furosemide Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Furosemide Tablet [State Of Florida Doh Central Pharmacy]
  • Cardinal Health
    Furosemide Tablet [Cardinal Health]
  • Bayer Healthcare Llc
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  • Cardinal Health
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  • Ivax Pharmaceuticals, Inc.
    Furosemide Tablet [Ivax Pharmaceuticals, Inc.]
  • Aphena Pharma Solutions – Tennessee, Llc
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  • Aphena Pharma Solutions – Tennessee, Llc
    Furosemide Tablet [Aphena Pharma Solutions – Tennessee, Llc]
  • Aphena Pharma Solutions – Tennessee, Llc
    Furosemide Tablet [Aphena Pharma Solutions – Tennessee, Llc]
  • Aphena Pharma Solutions – Tennessee, Llc
    Furosemide Tablet [Aphena Pharma Solutions – Tennessee, Llc]
  • Cardinal Health
    Furosemide Tablet [Cardinal Health]
  • Cardinal Health
    Furosemide Tablet [Cardinal Health]
  • Mylan Pharmaceuticals Inc.
    Furosemide Tablet [Mylan Pharmaceuticals Inc.]
  • Mylan Institutional Inc.
    Furosemide Tablet [Mylan Institutional Inc.]
  • American Regent, Inc.
    Furosemide Injection [American Regent, Inc.]
  • Readymeds
    Furosemide Tablet [Readymeds]
  • Claris Lifesciences, Inc
    Furosemide Injection, Solution [Claris Lifesciences, Inc]
  • Proficient Rx Lp
    Furosemide Tablet [Proficient Rx Lp]
  • Preferred Pharmaceuticals, Inc.
    Furosemide Tablet [Preferred Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Furosemide Tablet [Preferred Pharmaceuticals, Inc.]
  • Bryant Ranch Prepack
    Furosemide Tablet [Bryant Ranch Prepack]
  • Vedco, Inc.
    Furosemide Tablet [Vedco, Inc.]
  • Tya Pharmaceuticals
    Furosemide Tablet [Tya Pharmaceuticals]
  • Remedyrepack Inc.
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  • Cardinal Health
    Furosemide Tablet [Cardinal Health]
  • Mwi/vetone
    Furosemide Tablet [Mwi/vetone]
  • Direct Rx
    Furosemide Tablet [Direct Rx]
  • Heritage Pharmaceuticals Inc.
    Furosemide Injection, Solution [Heritage Pharmaceuticals Inc.]
  • Safecor Health, Llc
    Furosemide Tablet [Safecor Health, Llc]
  • Cardinal Health
    Furosemide Tablet [Cardinal Health]
  • Clinical Solutions Wholesale, Llc
    Furosemide Tablet [Clinical Solutions Wholesale, Llc]
  • Clinical Solutions Wholesale, Llc
    Furosemide Tablet [Clinical Solutions Wholesale, Llc]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Furosemide Tablet [Remedyrepack Inc. ]

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