2.1 Recommended Dose
Determine the dose based on the type of diagnostic procedure, the route of administration and expected procedure duration [see Clinical Pharmacology (12.2)].
The usual dose to inhibit movement of the:
Stomach and small bowel is 0.2 mg to 0.5 mg given intravenously or 1 mg given intramuscularly.
Colon is 0.5 mg to 0.75 mg given intravenously or 1 mg to 2 mg given intramuscularly.
Bolus doses above 1 mg administered intravenously have caused nausea and vomiting and are not recommended [see Adverse Reactions (6)].
2.2 Reconstitution of the Lyophilized Powder
Glucagon for Injection is a lyophilized powder, which requires reconstitution with Sterile Water for Injection prior to intravenous or intramuscular use.
Using a syringe, withdraw 1 mL of Sterile Water for Injection and inject into the vial containing Glucagon for Injection lyophilized powder.
Shake the vial gently until the powder is completely dissolved and no particles remain in the reconstituted solution.
Visually inspect the reconstituted solution for particulate matter and discoloration prior to administration. The reconstituted solution should be clear and of water-like consistency. Discard the reconstituted solution if there are signs of gel formation or particles.
The reconstituted solution has a concentration of approximately 1 mg of glucagon per mL.
Use the reconstituted glucagon immediately after reconstitution.
2.3 Important Administration Instructions
Glucagon for Injection must be administered by medical personnel.
The timing of administration of Glucagon for Injection depends upon the organ under examination and route of administration [see Clinical Pharmacology (12.2)].
If given intravenously, administer Glucagon for Injection as a bolus over a time period of 1 minute.
Discard any unused portion.
After the end of the diagnostic procedure, give oral carbohydrates to patients who have been fasting, if this is compatible with the diagnostic procedure.
2.1 Recommended Dose
Determine the dose based on the type of diagnostic procedure, the route of administration and expected procedure duration [see Clinical Pharmacology (12.2)].
The usual dose to inhibit movement of the:
Stomach and small bowel is 0.2 mg to 0.5 mg given intravenously or 1 mg given intramuscularly.
Colon is 0.5 mg to 0.75 mg given intravenously or 1 mg to 2 mg given intramuscularly.
Bolus doses above 1 mg administered intravenously have caused nausea and vomiting and are not recommended [see Adverse Reactions (6)].
2.2 Reconstitution of the Lyophilized Powder
Glucagon for Injection is a lyophilized powder, which requires reconstitution with Sterile Water for Injection prior to intravenous or intramuscular use.
Using a syringe, withdraw 1 mL of Sterile Water for Injection and inject into the vial containing Glucagon for Injection lyophilized powder.
Shake the vial gently until the powder is completely dissolved and no particles remain in the reconstituted solution.
Visually inspect the reconstituted solution for particulate matter and discoloration prior to administration. The reconstituted solution should be clear and of water-like consistency. Discard the reconstituted solution if there are signs of gel formation or particles.
The reconstituted solution has a concentration of approximately 1 mg of glucagon per mL.
Use the reconstituted glucagon immediately after reconstitution.
2.3 Important Administration Instructions
Glucagon for Injection must be administered by medical personnel.
The timing of administration of Glucagon for Injection depends upon the organ under examination and route of administration [see Clinical Pharmacology (12.2)].
If given intravenously, administer Glucagon for Injection as a bolus over a time period of 1 minute.
Discard any unused portion.
After the end of the diagnostic procedure, give oral carbohydrates to patients who have been fasting, if this is compatible with the diagnostic procedure.