Hycamtin
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Questions & Answers
Side Effects & Adverse Reactions
Warnings
Do not use if you are allergic to esomeprazole
- trouble or pain swallowing food, vomiting with blood, or bloody or black stools
- heartburn with lightheadedness, sweating or dizziness
- chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadedness
- frequent chest pain
These may be signs of a serious condition. See your doctor.
- had heartburn over 3 months. This may be a sign of a more serious condition.
- frequent wheezing, particularly with heartburn
- unexplained weight loss
- nausea or vomiting
- stomach pain
Ask a doctor or pharmacist before use if you are taking
- warfarin, clopidogrel or cilostazol (blood-thinning medicines)
- prescription antifungal or anti-yeast medicines
- digoxin (heart medicine)
- diazepam (anxiety medicine)
- tacrolimus or mycophenolate mofetil (immune system medicines)
- prescription antiretrovirals (medicines for HIV infection)
- methotrexate (arthritis medicine)
- your heartburn continues or worsens
- you need to take this product for more than 14 days
- you need to take more than 1 course of treatment every 4 months
- you get diarrhea
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
- trouble or pain swallowing food, vomiting with blood, or bloody or black stools
- heartburn with lightheadedness, sweating or dizziness
- chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadedness
- frequent chest pain
These may be signs of a serious condition. See your doctor.
Ask a doctor before use if you have- had heartburn over 3 months. This may be a sign of a more serious condition.
- frequent wheezing, particularly with heartburn
- unexplained weight loss
- nausea or vomiting
- stomach pain
Ask a doctor or pharmacist before use if you are taking
- warfarin, clopidogrel or cilostazol (blood-thinning medicines)
- prescription antifungal or anti-yeast medicines
- digoxin (heart medicine)
- diazepam (anxiety medicine)
- tacrolimus or mycophenolate mofetil (immune system medicines)
- prescription antiretrovirals (medicines for HIV infection)
- methotrexate (arthritis medicine)
- your heartburn continues or worsens
- you need to take this product for more than 14 days
- you need to take more than 1 course of treatment every 4 months
- you get diarrhea
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Uses
- treats frequent heartburn (occurs 2 or more days a week)
- not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect
History
There is currently no drug history available for this drug.
Other Information
There are no additional details available for this product.
Sources
Hycamtin Manufacturers
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Glaxosmithkline Llc
![Hycamtin (Topotecan Hydrochloride) Injection, Powder, Lyophilized, For Solution [Glaxosmithkline Llc]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Hycamtin | Pfizer Consumer Healthcare
Directions
adults 18 years of age and older this product is to be used once a day (every 24 hours), every day for 14 days may take 1 to 4 days for full effect
14-Day Course of Treatment swallow 1 capsule with a glass of water before eating in the morning take every day for 14 days do not take more than 1 capsule a day swallow whole. Do not crush or chew capsules. do not use for more than 14 days unless directed by your doctor Repeated 14-Day Courses (if needed) you may repeat a 14-day course every 4 months do not take for more than 14 days or more often than every 4 months unless directed by a doctor children under 18 years of age: ask a doctor before use. Heartburn in children may sometimes be caused by a serious condition. -
Glaxosmithkline Llc
Hycamtin | Glaxosmithkline Llc
2.1 Recommended DosingThe recommended dose of HYCAMTIN capsules is 2.3 mg/m2/day orally once daily for 5 consecutive days repeated every 21 days. Round the dose to the nearest 0.25 mg, and prescribe the minimum number of 1-mg and 0.25-mg capsules. Prescribe the same number of capsules for each of the 5 dosing days.
Take HYCAMTIN capsules with or without food. Swallow capsules whole. Do not chew, crush, or divide the capsules. Do not prescribe a replacement dose for emesis.
Diarrhea:
Do not administer HYCAMTIN capsules to patients with Grade 3 or 4 diarrhea. After recovery to Grade 1 or less, reduce the dose of HYCAMTIN by 0.4 mg/m2/day for subsequent courses [see Warnings and Precautions (5.2)].
2.2 Dose Modification GuidelinesHematologic Toxicities:
Do not administer subsequent courses of HYCAMTIN capsules until neutrophils recover to greater than 1,000 cells/mm3, platelets recover to greater than 100,000 cells/mm3, hemoglobin levels recover to greater than or equal to 9.0 g/dL (with transfusion if necessary). • Dose reduce HYCAMTIN capsules by 0.4 mg/m2/day for: neutrophil counts of less than 500 cells/mm3 associated with fever or infection or lasting for 7 days or more; neutrophil counts of 500 to 1,000 cells/mm3 lasting beyond day 21 of the treatment course; platelet counts less than 25,000 cells/mm3. Renal Impairment: The recommended starting doses of HYCAMTIN capsules in patients with moderate and severe renal impairment are as follows: Table 1. Dose Reduction Guidelines for Renal Impairment Degree of Renal Impairment Creatinine Clearancea (mL/min) Dose (mg/m2)/day Moderate 30 – 49 1.5 b Severe <30 0.6 baCalculated with the Cockroft-Gault method using ideal body weight.
bDose can be increased after the first course by 0.4 mg/m2/day if no severe hematologic or gastrointestinal toxicities occur.
![Hycamtin (Topotecan Hydrochloride) Capsule [Glaxosmithkline Llc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=140399d0-4b28-4100-b792-3d1aa3c3e29c&name=hycamtin-spl-graphic-03.jpg)
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