Immiticide

Immiticide Manufacturers

• Merial Limited
  

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  Immiticide | Merial Limited

  

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  IMMITICIDE should be administered ONLY by deep intramuscular injection in the epaxial (lumbar) muscles in the third through fifth lumbar region (see graphic). DO NOT ADMINISTER AT ANY OTHER SITE. Avoid superficial injection or leakage. Use a 23 gauge 1 inch needle for dogs equal to or less than 10 kg (22 lb) in weight. Use a 22 gauge 1 1/2 inch needle for dogs greater than 10 kg (22 lb). Use alternating sides with each administration. If repeated administrations are warranted avoid injecting at the same lumbar location. Record the location of the first injection(s) in the patient's medical record for future reference.

  Disease Classification

  It is vital to classify the severity of heartworm disease to apply the appropriate dosage regime for IMMITICIDE (See INDICATIONS).

  Class 1 and 2

  If necessary, dogs should be stabilized prior to treatment. IMMITICIDE should be administered intramuscularly in the lumbar (L3 - L5) muscles at a dose of 2.5 mg/kg twice, 24 hours apart (See Dosing Table). Four months following treatment, a second treatment series (2.5 mg/kg twice, 24 hours apart) can be elected taking into consideration the response to the first IMMITICIDE treatment and the condition, age, and use of the dog. Worms that were too young to be killed by the first treatment series, i.e., < 4 months, may be killed by a second treatment series.

  Class 3 Alternate Dosing Regime

  Dogs with severe (Class 3) heartworm disease should be stabilized prior to treatment and then dosed intramuscularly in the lumbar (L3 - L5) muscles with a single injection of 2.5 mg/kg then approximately 1 month later with 2.5 mg/kg administered twice 24 hours apart (See Dosing Table).

  Dosing Table

  Care must be taken to administer the proper dose. Accurately weigh the dog and calculate the volume to be injected based on the dose of 2.5 mg/kg (1.1 mg/lb). This is equivalent to 0.1 mL/kg (0.045 mL/lb). The following table should be used as a guide to ensure that the proper volume has been calculated.

    * Limited data were collected on the administration > 5.0 mL at a single injection site. WEIGHT (LB) 2.2 4.4 6.6 8.8 11.0 13.2 15.4 17.6 19.8 22.0 44.0 66.0 88.0 110.0 WEIGHT (KG) 1 2 3 4 5 6 7 8 9 10 20 30 40 50 VOLUME PER INJECTION 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9   1.0   2.0   3.0   4.0   5.0* Preparation

  IMMITICIDE should be aseptically reconstituted only with 2.0 mL of sterile water for injection (provided as 2.0 mL sterile water for injection USP). This provides 2.5 mg melarsomine dihydrochloride per 0.1 mL of injectable solution. Two 50 mg vials will be required for dogs weighing > 20 kg and 40 kg and 3 vials will be required for dogs > 40 kg and 60 kg. Use immediately. Reconstituted solution may be used within 24 hours if refrigerated and kept from light.

  Treatment Response

  A baseline can be established pre-treatment by using commercially available in-office heartworm antigen test kits prior to treatment. Treatment response can be assessed best by heartworm antigen testing applied 4 months after treatment. A successful treatment is determined to be conversion from an antigen positive to an antigen negative status. In dogs with signs of heartworm disease, gradual improvement should be observed as the long-term effects of the heartworm infection resolve. Some dogs may have chronic effects that will not totally resolve.

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