Intersol
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Questions & Answers
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FDA Labeling Changes
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Uses
Rx only
For use with the AMICUS Separator only.
Indications and Usage:
InterSol solution is an isotonic solution designed to replace a proportion of the plasma used in the storage of AMICUS™-derived leukoreduced apheresis platelets under standard blood banking conditions. There is no direct therapeutic effect to be expected from the formulation. The solution should never be infused directly into a patient.
InterSol platelets are leukocyte-reduced apheresis platelet concentrates that are stored in a mix of 65% InterSol and 35% plasma, nominal. InterSol platelets prepared within the range of Table 1 may be stored for up to 5 days at 20-24°C, with continuous agitation.
History
There is currently no drug history available for this drug.
Other Information
Description:
InterSol solution is an isotonic solution designed to replace a proportion of the plasma used in the storage of platelets. The solution contains constituents that are naturally occurring components present in many cellular systems: sodium acetate as a nutrient, sodium citrate to prevent platelet clumping and activation, sodium phosphate for buffering and sodium chloride for osmolarity. InterSol solution does not have a pharmacological effect in vivo, but rather acts to provide the appropriate environment and nutrients in lieu of a portion of the plasma normally used for the storage of platelets.
Sources
Intersol Manufacturers
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Fenwal, Inc.
![Intersol (Platelet Additive 3) Solution [Fenwal, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Intersol | Fenwal, Inc.
Dosage and Administration:
InterSol solution may only be used with the AMICUS Separator System using an AMICUS Apheresis Kit with a Platelet Additive Solution (PAS) Connector. For full instructions on the use of InterSol solution with the AMICUS separator, see the AMICUS Operator’s Manual.Prior to use of InterSol solution, check the plastic container for leaks by squeezing the bag firmly. If leaks are found, discard solution.
To connect the InterSol solution to the AMICUS Apheresis Kit:
1) Close the clamp on the PAS Connector line.
2) Remove the protective cap from the membrane port on the InterSol solution container.
3) Insert the spike on the PAS Connector line into the membrane port on the InterSol solution container until firmly seated.
4) For the addition of InterSol solution to the platelet product, follow the instructions provided in the AMICUS Separator Operator’s Manual.
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