Iquix
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Questions & Answers
Side Effects & Adverse Reactions
NOT FOR INJECTION.
IQUIX® solution should not be injected subconjunctivally, nor should it be introduced directly into the anterior chamber of the eye.
In patients receiving systemic quinolones, serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported, some following the first dose. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, angioedema (including laryngeal, pharyngeal or facial edema), airway obstruction, dyspnea, urticaria, and itching. If an allergic reaction to levofloxacin occurs, discontinue the drug. Serious acute hypersensitivity reactions may require immediate emergency treatment. Oxygen and airway management should be administered as clinically indicated.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
IQUIX® solution is indicated for the treatment of corneal ulcer caused by susceptible strains of the following bacteria:
| GRAM-POSITIVE BACTERIA: | GRAM-NEGATIVE BACTERIA: |
|---|---|
|
|
| Corynebacterium species * | Pseudomonas aeruginosa |
| Staphylococcus aureus | Serratia marcescens* |
| Staphylococcus epidermidis | |
| Streptococcus pneumoniae | |
| Viridans group streptococci* | |
History
There is currently no drug history available for this drug.
Other Information
IQUIX® (levofloxacin ophthalmic solution) 1.5% is a sterile topical ophthalmic solution. Levofloxacin is a fluoroquinolone antibacterial active against a broad spectrum of Gram-positive and Gram-negative ocular pathogens. Levofloxacin is a fluorinated 4-quinolone containing a six-member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure. Levofloxacin is the pure(-)-(S)-enantiomer of the racemic drug substance, ofloxacin. It is more soluble in water at neutral pH than ofloxacin.
Chemical Name: (-)(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate.
Levofloxacin (hemihydrate) is a yellowish-white crystalline powder.
Each mL of IQUIX® contains 15.36 mg of levofloxacin hemihydrate equivalent to 15 mg levofloxacin.
Active: Levofloxacin 1.5% (15 mg/mL); Inactives: glycerin and water. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH to approximately 6.5. IQUIX® solution is isotonic with an osmolality of approximately 290 mOsm/kg.
Sources
Iquix Manufacturers
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Vistakon Pharmaceuticals Llc
![Iquix (Levofloxacin) Solution [Vistakon Pharmaceuticals Llc]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Iquix | Vistakon Pharmaceuticals Llc
Days 1 through 3Instill one to two drops in the affected eye(s) every 30 minutes to 2 hours while awake and approximately 4 and 6 hours after retiring.
Day 4 through treatment completionInstill one to two drops in the affected eye(s) every 1 to 4 hours while awake.
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