Isoflurane Usp

Isoflurane Usp

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Questions & Answers

Side Effects & Adverse Reactions

Increasing depth of anesthesia with isoflurane may increase hypotension and respiratory depression.  The electroencephalographic pattern associated with deep anesthesia is characterized by burst suppression, spiking, and isoelectric periods.4

Since levels of anesthesia may be altered easily and rapidly, only vaporizers producing predictable percentage concentrations of isoflurane should be used.  (See DOSAGE AND ADMINISTRATION).

The action of nondepolarizing relaxants is augmented by isoflurane.  Less than the usual amounts of these drugs should be used.  If the usual amounts of nondepolarizing relaxants are given, the time for recovery from myoneural blockade will be longer in the presence of isoflurane than in the presence of other commonly used anesthetics.

Not for use in horses intended for food.

Keep out of reach of children.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs.


There is currently no drug history available for this drug.

Other Information

Isoflurane, USP is a nonflammable, nonexplosive general inhalation anesthetic agent. Its chemical name is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is:


Each mL contains 99.9% isoflurane.
Some physical constants are:  
Molecular weight                             184.5
Boiling point at 760 mm Hg              48.5° C (uncorr.)
Refractive index                               1.2990-1.3005
Specific gravity 25°/25° C                1.496
Vapor pressure in mm Hg** 20°C     238   
                                            25°C     295   
                                            30°C     367   
                                            35°C     450
**Equation for vapor pressure calculation:  
log10Pvap = A + B/T                            
A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)  

Partition coefficients at 37° C:      
Water/gas             0.61  
Blood/gas             1.43  
Oil/gas                  90.8  

Partition coefficients at 25° C - rubber and plastic  
Conductive rubber/gas       62.0  
Butyl rubber/gas                 75.0  
Polyvinyl chloride/gas         110.0  
Polyethylene/gas                 ~2.0  
Polyurethane/gas                ~1.4  
Polyolefin/gas                      ~1.1  
Butyl acetate/gas                 ~2.5

Purity by gas chromatography   -   >99.9%    

Lower limit of flammability in oxygen or nitrous oxide at 9 joules/sec. and 23° C    -   None    

Lower limit of flammability in oxygen or nitrous oxide at 900 joules/sec. and 23° C      -      Greater than useful concentration in anesthesia.  

MAC (Minimum Alveolar Concentration) is 1.31% in horses1 and 1.28% in dogs.6  

Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.

Isoflurane Usp Manufacturers

  • Rxelite Holdings Inc.
    Isoflurane Usp (Isoflurane) Inhalant [Rxelite Holdings Inc.]

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