Isosorbide Dinitrate

Isosorbide Dinitrate

Isosorbide Dinitrate Recall

Get an alert when a recall is issued.

Questions & Answers

Side Effects & Adverse Reactions

Amplification of the vasodilatory effects of isosorbide dinitrate by sildenafil can result in severe hypotension. The time course and dose dependence of this interaction have not been studied. Appropriate supportive care has not been studied, but it seems reasonable to treat this as a nitrate overdose, with elevation of the extremities and with central volume expansion.

The benefits of immediate-release oral isosorbide dinitrate in patients with acute myocardial infarction or congestive heart failure have not been established. If one elects to use isosorbide dinitrate in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of hypotension and tachycardia. Because the effects of oral isosorbide dinitrate are so difficult to terminate rapidly, this formulation is not recommended in these settings.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Isosorbide dinitrate tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of immediate-release oral isosorbide dinitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.

History

There is currently no drug history available for this drug.

Other Information

Isosorbide dinitrate, an organic nitrate, is a vasodilator with effects on both arteries and veins. The chemical name for isosorbide dinitrate is 1,4:3,6-dianhydro-D-glucitol 2, 5-dinitrate. The compound has the following structural formula:

This is the structural formula

C6H8N208

MW 236.14

Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.

Isosorbide dinitrate tablets are available for oral administration as 5 mg, 10 mg, 20 mg, or 30 mg tablets.

Each tablet contains the following inactive ingredients: lactose anhydrous, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and stearic acid. In addition, the 20 mg tablet contains D&C Yellow #10, FD&C Blue #1, and FD&C Yellow #6; the 30 mg tablet contains FD&C Blue #1.

Isosorbide Dinitrate Manufacturers


  • Cardinal Health
    Isosorbide Dinitrate Tablet [Cardinal Health]
  • Cardinal Health
    Isosorbide Dinitrate Tablet [Cardinal Health]
  • American Health Packaging
    Isosorbide Dinitrate Tablet [American Health Packaging]
  • West-ward Pharmaceutical Corp.
    Isosorbide Dinitrate (Isosorbide Dinitrate) Tablet [West-ward Pharmaceutical Corp.]
  • Caraco Pharmaceutical Laboratories Ltd.
    Isosorbide Dinitrate (Isosorbide Dinitrate) Tablet, Extended Release [Caraco Pharmaceutical Laboratories Ltd.]
  • Rising Pharmaceuticals Inc
    Isosorbide Dinitrate Tablet, Extended Release [Rising Pharmaceuticals Inc]
  • Kaiser Foundation Hospitals
    Isosorbide Dinitrate Tablet, Extended Release [Kaiser Foundation Hospitals]
  • Physicians Total Care, Inc.
    Isosorbide Dinitrate Tablet, Extended Release [Physicians Total Care, Inc.]
  • Kaiser Foundation Hospitals
    Isosorbide Dinitrate Tablet, Extended Release [Kaiser Foundation Hospitals]
  • Remedyrepack Inc.
    Isosorbide Dinitrate Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Isosorbide Dinitrate Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Isosorbide Dinitrate Tablet [Remedyrepack Inc. ]
  • Kaiser Foundation Hospitals
    Isosorbide Dinitrate (Isosorbide Dinitrate) Tablet, Extended Release [Kaiser Foundation Hospitals]
  • Sandoz Inc
    Isosorbide Dinitrate Tablet [Sandoz Inc]
  • American Health Packaging
    Isosorbide Dinitrate Tablet [American Health Packaging]
  • West-ward Pharmaceutical Corp
    Isosorbide Dinitrate Tablet [West-ward Pharmaceutical Corp]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Isosorbide Dinitrate Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Par Pharmaceutical Inc.
    Isosorbide Dinitrate (Isosorbide Dinitrate) Tablet [Par Pharmaceutical Inc.]
  • West-ward Pharmaceutical Corp
    Isosorbide Dinitrate Tablet [West-ward Pharmaceutical Corp]
  • Corepharma, Llc
    Isosorbide Dinitrate Tablet, Extended Release [Corepharma, Llc]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Isosorbide Dinitrate Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Remedyrepack Inc.
    Isosorbide Dinitrate Tablet [Remedyrepack Inc. ]
  • Bryant Ranch Prepack
    Isosorbide Dinitrate Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Isosorbide Dinitrate Tablet [Bryant Ranch Prepack]
  • A-s Medication Solutions Llc
    Isosorbide Dinitrate Tablet [A-s Medication Solutions Llc]
  • American Health Packaging
    Isosorbide Dinitrate Tablet [American Health Packaging]
  • Major Pharmaceuticals
    Isosorbide Dinitrate Tablet [Major Pharmaceuticals]
  • Bluepoint Laboratories
    Isosorbide Dinitrate Tablet [Bluepoint Laboratories]
  • Major Pharmaceuticals
    Isosorbide Dinitrate Tablet [Major Pharmaceuticals]
  • Remedyrepack Inc.
    Isosorbide Dinitrate Tablet [Remedyrepack Inc. ]
  • State Of Florida Doh Central Pharmacy
    Isosorbide Dinitrate Tablet [State Of Florida Doh Central Pharmacy]
  • Carilion Materials Management
    Isosorbide Dinitrate Tablet [Carilion Materials Management]
  • Carilion Materials Management
    Isosorbide Dinitrate Tablet [Carilion Materials Management]
  • Carilion Materials Management
    Isosorbide Dinitrate Tablet [Carilion Materials Management]
  • Carilion Materials Management
    Isosorbide Dinitrate Tablet [Carilion Materials Management]
  • Carilion Materials Management
    Isosorbide Dinitrate Tablet, Extended Release [Carilion Materials Management]
  • Cardinal Health
    Isosorbide Dinitrate Tablet [Cardinal Health]
  • American Health Packaging
    Isosorbide Dinitrate Tablet [American Health Packaging]

Login To Your Free Account