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IZBA (travoprost ophthalmic solution) 0.003% is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
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Travoprost is a synthetic prostaglandin F2α analog. Its chemical name is [1R-[1α (Z),2ß (1E,3R*),3α ,5 α]]-7-[3,5-Dihydroxy-2-[3- hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular formula of C26H35F3O6 and a molecular weight of 500.55. The chemical structure of travoprost is:
Travoprost is a clear, colorless to slightly yellow oil that is very soluble in acetonitrile, methanol, octanol, and chloroform. It is practically insoluble in water.
IZBA (travoprost ophthalmic solution) 0.003% is supplied as sterile, isotonic, buffered aqueous solution of travoprost with a pH of approximately 6.8 and an osmolality of approximately 290 mOsmol/kg.
IZBA contains Active: travoprost 0.03 mg/mL; Preservative: POLYQUAD* (polyquaternium-1) 0.01mg/mL; Inactives: polyoxyethylene hydrogenated castor oil 40, propylene glycol, boric acid, mannitol, sodium chloride, sodium hydroxide and/or hydrochloric acid (to adjust pH) and purified water, USP.