Recommended Dosage for K-BroVet:
To achieve a serum level of approximately 1 mg/mL, give 120 mg/kg PO daily for 5 days then reduce 30 mg/kg PO once daily. To Achieve a serum level of approximately 1.5 mg/mL, give 160 mg/kg PO for 5 days and then reduce to 40 mg/kg PO once daily thereafter.
(R-21)
Among dogs responses to bromide may vary, treatment should be tailored to the individual dog, based on serum bromide concentration, success of seizure control, and the observation of adverse effects. Steady state serum concentrations generally take 4 to 5 months in dogs; therapeutic concentrations may be reached before steady state at about 4 weeks after the beginning of treatment, serum bromide concentrations may be tested to assess the response to product and, if results are satisfactory , the next testing for steady state serum levels is typically about 4 months. If the dog's serum concentration is within range and the dog is doing well in the therapeutic range , serum concentrations may then be tested after 6 to 12 months. Serum bromide is typically evaluated at the end of the loading period, then as described above when an animal is started with a loading dose.
Dogs- An oral dose of 30 mg of Bromide per kg of body weight every twelve hours for 115 days produced a steady state serum concentration 2.45 mg/mL (range, 1.78 to 2.69 mg/mL) in Beagles fed a diet containing 0.55% chloride.
(R-3)
