Leader Cold And Flu

Leader Cold And Flu Manufacturers

• Cardinal Health
  

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  Leader Cold And Flu | Remedyrepack Inc.

  

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  800 mg every 4 hours orally, 5 times daily for 7 to 10 days.

   

   

  200 mg every 4 hours, 5 times daily for 10 days.

   

  400 mg 2 times daily for up to 12 months, followed by re-evaluation. Alternative regimens have included doses ranging from 200 mg 3 times daily to 200 mg 5 times daily.

  The frequency and severity of episodes of untreated genital herpes may change over time. After 1 year of therapy, the frequency and severity of the patient’s genital herpes infection should be re-evaluated to assess the need for continuation of therapy with acyclovir.

   

  200 mg every 4 hours, 5 times daily for 5 days. Therapy should be initiated at the earliest sign or symptom (prodrome) of recurrence.

   

   

  20 mg/kg per dose orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose for chickenpox.

   

  800 mg 4 times daily for 5 days.

  Intravenous acyclovir is indicated for the treatment of varicella-zoster infections in immunocompromised patients.

  When therapy is indicated, it should be initiated at the earliest sign or symptom of chickenpox. There is no information about the efficacy of therapy initiated more than 24 hours after onset of signs and symptoms.

   

  In patients with renal impairment, the dose of acyclovir should be modified as shown in Table 3:

  Table 3. Dosage Modification for Renal Impairment

  Creatinine

  Adjusted Dosage Regimen

  Normal Dosage

  Regimen

  Clearance

  (mL/min/1.73 m2)

  Dose

  (mg)

  Dosing Interval

  200 mg every 4 hours

  >10

  200

  every 4 hours, 5x daily

  0-10

  200

  every 12 hours

  400 mg every 12 hours

  >10

  0-10

  400

  200

  every 12 hours

  every 12 hours

  800 mg every 4 hours

  >25

  800

  every 4 hours, 5x daily

  10-25

  800

  every 8 hours

  0-10

  800

  every 12 hours

   

  For patients who require hemodialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours. This results in a 60% decrease in plasma concentrations following a 6-hour dialysis period. Therefore, the patient’s dosing schedule should be adjusted so that an additional dose is administered after each dialysis.

   

  No supplemental dose appears to be necessary after adjustment of the dosing interval.

   

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