Lidocaine Hydrochloride And Epinephrine

Lidocaine Hydrochloride And Epinephrine

Lidocaine Hydrochloride And Epinephrine Recall

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Questions & Answers

Side Effects & Adverse Reactions

DENTAL PRACTITIONERS WHO EMPLOY LOCAL ANESTHETIC AGENTS SHOULD BE WELL VERSED IN DIAGNOSIS AND MANAGEMENT OF EMERGENCIES WHICH MAY ARISE FROM THEIR USE. RESUSCITATIVE EQUIPMENT, OXYGEN AND OTHER RESUSCITATIVE DRUGS SHOULD BE AVAILABLE FOR IMMEDIATE USE.

To minimize the likelihood of intravascular injection, aspiration should be performed before the local anesthetic solution is injected. If blood is aspirated, the needle must be repositioned until no return of blood can be elicited by aspiration. Note, however, that the absence of blood in the syringe does not assure that intravascular injection will be avoided.

Lidocaine HCl with epinephrine solutions contain sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Lidocaine HCl and epinephrine injections, USP are indicated for production of local anesthesia by nerve block or infiltration techniques. Only accepted procedures for these techniques as described in standard textbooks are recommended.

History

There is currently no drug history available for this drug.

Other Information

Lidocaine HCl and Epinephrine Injection, USP are sterile, nonpyrogenic, isotonic solutions that contain a local anesthetic agent with epinephrine (as bitartrate) and are administered parenterally by injection. See INDICATIONS AND USAGE for specific uses. The quantitative composition of each available solution is shown in Table 1.

Lidocaine HCl and Epinephrine Injection, USP contain lidocaine hydrochloride, which is chemically designated as acetamide, 2-(diethylamino)- [(methylamino) methyl] benzyl alcohol and has the N-(2,6-dimethylphenyl)-, monohydrochloride and has the following structural formula:

structural formula lidocaine hcl and epinephrine injection

Epinephrine is (-)-3,4-Dihydroxy-a-[(methylamino) methyl] benzyl alcohol and has the following structural formula:

structural formula epinephrine


Table 1. Composition of Available Solutions
PRODUCT IDENTIFICATION
FORMULA
Dental Lidocaine HCl Concentration
Epinephrine (as the bitartrate dilution)
Citric Acid
Sodium Chloride
Sodium Metabisulfite
%
(mg/mL)
(mg/mL)
(mg/mL)
(mg/mL)
(mg/mL)

2

20

1:100,000 (0.01 mg/mL)

0.2

6

0.5

2

20

1:50,000 (0.02 mg/mL)

0.2

6

0.5


NOTE: The pH of all solutions is adjusted to USP limits with sodium hydroxide and/or hydrochloric acid. Filled under nitrogen.




Lidocaine Hydrochloride And Epinephrine Manufacturers


  • Hospira, Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride,epinephrine Bitartrate) Injection, Solution [Hospira, Inc.]
  • Mckesson Packaging Services Business Unit Of Mckesson Corporation
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Mckesson Packaging Services Business Unit Of Mckesson Corporation]
  • General Injectables & Vaccines, Inc
    Lidocaine Hydrochloride And Epinephrine Injection [General Injectables & Vaccines, Inc]
  • General Injectables & Vaccines
    Lidocaine Hydrochloride And Epinephrine Injection, Solution [General Injectables & Vaccines]
  • General Injectables & Vaccines, Inc
    Lidocaine Hydrochloride And Epinephrine Injection [General Injectables & Vaccines, Inc]
  • Cardinal Health
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Cardinal Health]
  • A-s Medication Solutions Llc
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [A-s Medication Solutions Llc]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Cardinal Health
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Cardinal Health]
  • Cardinal Health
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Cardinal Health]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Remedyrepack Inc. ]
  • Us Medsource, Llc
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Us Medsource, Llc]
  • Us Medsource, Llc
    Lidocaine Hydrochloride And Epinephrine (Lidocaine Hydrochloride Anhydrous And Epinephrine) Injection, Solution [Us Medsource, Llc]
  • Hospira, Inc.
    Lidocaine Hydrochloride And Epinephrine Injection, Solution [Hospira, Inc.]

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