Lidocaine

Lidocaine

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Questions & Answers

Side Effects & Adverse Reactions

LIDOCAINE HYDROCHLORIDE INJECTION FOR INFILTRATION AND NERVE BLOCK SHOULD BE EMPLOYED ONLY BY CLINICIANS WHO ARE WELL VERSED IN DIAGNOSIS AND MANAGEMENT OF DOSE-RELATED TOXICITY AND OTHER ACUTE EMERGENCIES THAT MIGHT ARISE FROM THE BLOCK TO BE EMPLOYED AND THEN ONLY AFTER ENSURING THE IMMEDIATE AVAILABILITY OF OXYGEN, OTHER RESUSCITATIVE DRUGS, CARDIOPULMONARY EQUIPMENT AND THE PERSONNEL NEEDED FOR PROPER MANAGEMENT OF TOXIC REACTIONS AND RELATED EMERGENCIES (see also ADVERSE REACTIONS and PRECAUTIONS).  DELAY IN PROPER MANAGEMENT OF DOSE-RELATED TOXICITY, UNDERVENTILATION FROM ANY CAUSE AND/OR ALTERED SENSITIVITY MAY LEAD TO THE DEVELOPMENT OF ACIDOSIS, CARDIAC ARREST AND, POSSIBLY, DEATH.

Intra-articular infusions of local anesthetics following arthroscopic and other surgical procedures is an unapproved use, and there have been post-marketing reports of chondrolysis in patients receiving such infusions.  The majority of reported cases of chondrolysis have involved the shoulder joint; cases of gleno-humeral chondrolysis have been described in pediatric and adult patients following intra-articular infusions of local anesthetics with and without epinephrine for periods of 48 to 72 hours.  There is insufficient information to determine whether shorter infusion periods are not associated with these findings.  The time of onset of symptoms, such as joint pain, stiffness and loss of motion can be variable, but may begin as early as the 2nd month after surgery.  Currently, there is no effective treatment for chondrolysis; patients who experienced chondrolysis have required additional diagnostic and therapeutic procedures and some required arthroplasty or shoulder replacement.

To avoid intravascular injection, aspiration should be performed before the local anesthetic solution is injected.  The needle must be repositioned until no return of blood can be elicited by aspiration.  Note, however, that the absence of blood in the syringe does not guarantee that intravascular injection has been avoided.

Local anesthetic solutions containing antimicrobial preservatives (e.g., methylparaben) should not be used for epidural or spinal anesthesia because the safety of these agents has not been established with regard to intrathecal injection, either intentional or accidental.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Lidocaine Hydrochloride Injection, USP is indicated for the production of local anesthesia, by infiltration techniques, such as percutaneous injection, and by peripheral nerve block techniques, such as brachial plexus and inter-costal, when the accepted procedures for these techniques as described in standard textbooks are observed.

 

History

There is currently no drug history available for this drug.

Other Information

Lidocaine Hydrochloride Injection, USP is a local anesthetic which is a sterile, nonpyrogenic solution intended for parenteral injection.  See INDICATIONS AND USAGE for specific uses.

Lidocaine hydrochloride is chemically designated as 2-(Diethylamino)-2’, 6’-acetoxylidide monohydrochloride and has the following structural formula:

MM1

C14H22N2O HCl                              M.W. 288.82

Each mL contains: Lidocaine hydrochloride 10 or 20 mg; methylparaben 0.1%; sodium chloride (7 mg and 6 mg of sodium chloride for 1% and 2% respectively) to render it isotonic; Water for Injection q.s.  Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (5.0 to 7.0).

 

Lidocaine Manufacturers


  • Remedyrepack Inc.
    Lidocaine (Lidocaine Hydrochloride) Injection, Solution [Remedyrepack Inc. ]
  • Ndc, Inc.
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Ndc, Inc.]
  • Premier Value
    Lidocaine (Burn Relief) Aerosol, Spray [Premier Value]
  • General Injectables & Vaccines, Inc
    Lidocaine Injection, Solution [General Injectables & Vaccines, Inc]
  • Darby Dental Supply, Llc
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Darby Dental Supply, Llc]
  • Darby Dental Supply, Llc
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Darby Dental Supply, Llc]
  • Henry Scein Inc
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Henry Scein Inc]
  • Novocol Pharmaceutical Of Canada, Inc.
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Novocol Pharmaceutical Of Canada, Inc.]
  • Safco Dental Supply Co
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Safco Dental Supply Co]
  • Patterson Dental
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Patterson Dental ]
  • Carestream Health, Inc.
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Carestream Health, Inc.]
  • Benco Dental
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Benco Dental ]
  • Patterson Dental
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Patterson Dental ]
  • Benco Dental
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Benco Dental]
  • Carestream Health, Inc.
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Carestream Health, Inc.]
  • Novocol Pharmaceutical Of Canada, Inc.
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Novocol Pharmaceutical Of Canada, Inc.]
  • Henry Schein Inc.
    Lidocaine (Lidocaine Hydrochloride And Epinephrine Bitartrate) Injection, Solution [Henry Schein Inc. ]
  • Akorn, Inc.
    Lidocaine (Lidocaine Hydrochloride) Jelly [Akorn, Inc.]
  • Akorn, Inc.
    Lidocaine (Lidocaine Hydrochloride) Jelly [Akorn, Inc.]
  • Physicians Total Care, Inc.
    Lidocaine (Lidocaine Hydrochloride) Jelly [Physicians Total Care, Inc.]
  • App Pharmaceuticals, Llc
    Lidocaine (Lidocaine Hydrochloride) Injection, Solution [App Pharmaceuticals, Llc]
  • Pd-rx Pharmaceuticals, Inc.
    Lidocaine Cream [Pd-rx Pharmaceuticals, Inc.]
  • Sparhawk Laboratories, Inc.
    Lidocaine Injection [Sparhawk Laboratories, Inc.]
  • Aspen Veterinary Resources, Ltd.
    Lidocaine Injection [Aspen Veterinary Resources, Ltd.]
  • Vedco, Inc.
    Lidocaine Injection [Vedco, Inc.]
  • Akorn, Inc.
    Lidocaine (Lidocaine Hydrochloride) Jelly [Akorn, Inc.]
  • Cardinal Health
    Lidocaine (Lidocaine Hydrochloride) Injection, Solution [Cardinal Health]
  • Premier Brands Of America Inc.
    Lidocaine (Burn Relief Spray) Aerosol, Spray [Premier Brands Of America Inc.]
  • Cardinal Health
    Lidocaine (Lidocaine Hydrochloride) Injection, Solution [Cardinal Health]
  • Us Medsource, Llc
    Lidocaine (Lidocaine Hydrochloride) Injection, Solution [Us Medsource, Llc]
  • County Line Pharmaceuticals, Llc
    Lidocaine Cream [County Line Pharmaceuticals, Llc]
  • Actavis Pharma, Inc.
    Lidocaine (Lidocaine Hydrochloride) Jelly [Actavis Pharma, Inc.]
  • County Line Pharamceuticals
    Lidocaine Cream [County Line Pharamceuticals]
  • Avkare, Inc.
    Lidocaine (Lidocaine) Ointment [Avkare, Inc.]

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