Mecamylamine Hydrochloride

Mecamylamine Hydrochloride

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Questions & Answers

Side Effects & Adverse Reactions

Mecamylamine, a secondary amine, readily penetrates into the brain and thus may produce central nervous system effects. Tremor, choreiform movements, mental aberrations, and convulsions may occur rarely. These have occurred most often when large doses of Mecamylamine HCl were used, especially in patients with cerebral or renal insufficiency.

When ganglion blockers or other potent antihypertensive drugs are discontinued suddenly, hypertensive levels return. In patients with malignant hypertension and others, this may occur abruptly and may cause fatal cerebral vascular accidents or acute congestive heart failure. When Mecamylamine HCl is withdrawn, this should be done gradually and other antihypertensive therapy usually must be substituted. On the other hand, the effects of Mecamylamine HCl sometimes may last from hours to days after therapy is discontinued.

Legal Issues

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FDA Safety Alerts

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Manufacturer Warnings

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FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


For the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension


There is currently no drug history available for this drug.

Other Information

Mecamylamine HCl is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. It is N,2,3,3-tetramethyl-bicyclo [2.2.1] heptan- 2 -amine hydrochloride. Its empirical formula is C11H21N • HCl and its structural formula is:

Mecamylamine HCl MF

It is a white, odorless, o r practically odorless, crystalline powder, is highly stable, soluble in water and has a molecular weight of 203.75.Mecamylamine HCl is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCl. Inactive ingredients are calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, cornstarch, and talc.

Mecamylamine Hydrochloride Manufacturers

  • Turing Pharmaceuticals
    Mecamylamine Hydrochloride Tablet [Turing Pharmaceuticals]
  • Nexgen Pharma, Inc.
    Mecamylamine Hydrochloride Tablet [Nexgen Pharma, Inc.]

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