Methazolamide Recall

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Questions & Answers

Side Effects & Adverse Reactions

Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Hypersensitivity reactions may recur when a sulfonamide is readministered, irrespective of the route of administration.

If hypersensitivity or other serious reactions occur, the use of this drug should be discontinued.

Caution is advised for patients receiving high-dose aspirin and methazolamide concomitantly, as anorexia, tachypnea, lethargy, coma, and death have been reported with concomitant use of high-dose aspirin and carbonic anhydrase inhibitors.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Methazolamide Tablets are indicated in the treatment of ocular conditions where lowering intraocular pressure is likely to be of therapeutic benefit, such as chronic open-angle glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where lowering the intraocular pressure is desired before surgery.


There is currently no drug history available for this drug.

Other Information

Methazolamide, a sulfonamide derivative, is a white crystalline powder, weakly acidic, slightly soluble in water, alcohol and acetone. The chemical name for methazolamide is: N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazo1-2(3H)-ylidene]-acetamide and it has the following structural formula:

chemical structure

Molecular Formula: C5H8N4O3S2 Molecular Weight: 236.26

Each tablet, for oral administration, contains 25 mg or 50 mg of methazolamide USP. In addition, each tablet contains the following inactive ingredients: dibasic calcium phosphate dihydrate, glyceryl behenate, povidone, pregelatinized starch, and sodium starch glycolate.

Methazolamide Manufacturers

  • Ani Pharmaceuticals, Inc.
    Methazolamide Tablet [Ani Pharmaceuticals, Inc.]
  • Paddock Laboratories, Llc
    Methazolamide Tablet [Paddock Laboratories, Llc]
  • Fera Pharmaceuticals
    Methazolamide Tablet [Fera Pharmaceuticals]
  • Physicians Total Care, Inc.
    Methazolamide Tablet [Physicians Total Care, Inc.]
  • Sandoz Inc
    Methazolamide Tablet [Sandoz Inc]
  • Effcon Laboratories, Inc.
    Methazolamide Tablet [Effcon Laboratories, Inc.]
  • Carilion Materials Management
    Methazolamide Tablet [Carilion Materials Management]

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