Midodrine Hydrochloride

Midodrine Hydrochloride

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Questions & Answers

Side Effects & Adverse Reactions

Supine Hypertension:

The most potentially serious adverse reaction associated with midodrine hydrochloride therapy is marked elevation of supine arterial blood pressure (supine hypertension). Systolic pressure of about 200 mmHg were seen overall in about 13.4% of patients given 10 mg of midodrine HCl. Systolic elevations of this degree were most likely to be observed in patients with relatively elevated pre-treatment systolic blood pressures (mean 170 mmHg). There is no experience in patients with initial supine systolic pressure above 180 mmHg, as those patients were excluded from the clinical trials. Use of midodrine HCl tablets in such patients is not recommended. Sitting blood pressures were also elevated by midodrine HCl therapy. It is essential to monitor supine and sitting blood pressures in patients maintained on midodrine HCl.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

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Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because midodrine HCl can cause marked elevation of supine blood pressure (BP >200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and lifestyle alterations. The indication is based on midodrine HCl's effect on increases in 1-minute standing systolic blood pressure, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits of midodrine HCl, principally improved ability to perform life activities, have not been established. Further clinical trials are underway to verify and describe the clinical benefits of midodrine HCl.

After initiation of treatment, midodrine HCl tablets should be continued only for patients who report significant symptomatic improvement.


There is currently no drug history available for this drug.

Other Information

Name: Midodrine Hydrochloride Tablets

Dosage Form: 2.5 mg, 5 mg and 10 mg tablets for oral administration

Active Ingredient: Midodrine hydrochloride

Inactive Ingredients: Microcrystalline Cellulose, NF; Corn Starch, NF; Colloidal Silicon Dioxide, NF; Magnesium Stearate, NF; Talc, USP; FD&C Yellow No. 6 (5 mg tablet); Lake Blend Green (10 mg tablet).

Pharmacological Classification: Vasopressor/Antihypotensive

Chemical Names (USAN: Midodrine Hydrochloride): (1) Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-monohydrochloride,(±)-; (2) (±) -2-amino-N-((beta)-hydroxy-2,5-dimethoxyphenethyl)acetamide monohydrochloride BAN, INN, JAN: Midodrine

Structural Formula:

Structural Formula Midodrine

Molecular Formula: C12H18N2O4 HCl; Molecular Weight: 290.7

Organoleptic Properties: Odorless, white, crystalline powder

Solubility: Water: Soluble
                  Methanol: Sparingly soluble

pKa: 7.8 (0.3% aqueous solution)

pH: 3.5 to 5.5 (5% aqueous solution)

Melting Range: 200 to 203°C

Midodrine Hydrochloride Manufacturers

  • American Health Packaging
    Midodrine Hydrochloride Tablet [American Health Packaging]
  • Apotex Corp
    Midodrine Hydrochloride Tablet [Apotex Corp]
  • Physicians Total Care, Inc.
    Midodrine Hydrochloride Tablet [Physicians Total Care, Inc.]
  • Avkare, Inc.
    Midodrine Hydrochloride (Midodrine Hydrochloride) Tablet [Avkare, Inc.]
  • Upsher-smith Laboratories Inc.
    Midodrine Hydrochloride Tablet [Upsher-smith Laboratories Inc.]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Midodrine Hydrochloride Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Global Pharmaceuticals, Division Of Impax Laboratories Inc.
    Midodrine Hydrochloride Tablet [Global Pharmaceuticals, Division Of Impax Laboratories Inc.]
  • Cardinal Health
    Midodrine Hydrochloride Tablet [Cardinal Health]
  • Mylan Pharmaceuticals Inc.
    Midodrine Hydrochloride Tablet [Mylan Pharmaceuticals Inc.]
  • Avpak
    Midodrine Hydrochloride (Midodrine Hydrochloride) Tablet [Avpak]
  • Carilion Materials Management
    Midodrine Hydrochloride Tablet [Carilion Materials Management]
  • Mylan Institutional Inc.
    Midodrine Hydrochloride Tablet [Mylan Institutional Inc.]
  • American Health Packaging
    Midodrine Hydrochloride Tablet [American Health Packaging]

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