Morphine Sulfate Suppository
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Questions & Answers
Side Effects & Adverse Reactions
Morphine can cause tolerance, psychological and physical dependence. Withdrawal will occur on abrupt discontinuation or administration of a narcotic antagonist.
Morphine should be used with caution and in reduced dosage in patients who are concurrently receiving other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics, tricyclic antidepressants, and other CNS depressants (including alcohol). Respiratory depression, hypotension, and profound sedation or coma may result.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Morphine is indicated for the relief of severe chronic pain, and severe acute pain.
History
There is currently no drug history available for this drug.
Other Information
Each suppository for rectal administration contains 5 mg, 10 mg, 20 mg, or 30 mg of Morphine Sulfate in a bland, specially formulated Hydrogenated Vegetable Oil Base with BHA and BHT as preservatives, as well as other ingredients.
Chemically, Morphine Sulfate is, Morphinan-3, 6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5a,6a)-, sulfate (2:1) (salt), pentahydrate, which can be represented by the following structural formula:
Sources
Morphine Sulfate Suppository Manufacturers
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Paddock Laboratories, Llc
![Morphine Sulfate Suppository [Paddock Laboratories, Llc]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Morphine Sulfate Suppository | Paddock Laboratories, Llc
Usual Adult Dose: 10 to 20 mg every 4 hours or as directed by physician.
Dosage is a patient dependent variable, therefore increased dosage may be required to achieve adequate analgesia.
Note: Medication may suppress respiration in the elderly, the very ill, and those patients with respiratory problems, therefore lower doses may be required.
Morphine Dosage ReductionDuring the first two to three days of effective pain relief, the patient may sleep for many hours. This can be misinterpreted as the effect of excessive analgesic dosing rather than the first sign of relief of a pain exhausted patient. The dose, therefore, should be maintained for at least three days before reduction, if respiratory activity and other vital signs are adequate.
Following successful relief of severe pain, periodic attempts to reduce the narcotic dose should be made. Smaller doses or complete discontinuation of the narcotic analgesic may become feasible due to a physiologic change or the improved mental state of the patient.
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