Oxycodone And Acetaminophen
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Questions & Answers
Side Effects & Adverse Reactions
Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products.
The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen.
Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product that contains acetaminophen. Instruct patients to seek medical attention immediately upon ingestion of more than 4000 milligrams of acetaminophen per day, even if they feel well.
Rarely, acetaminophen may cause serious skin reactions such as acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. Patients should be informed about the signs of serious skin reactions, and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity.
There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to discontinue Oxycodone and Acetaminophen Tablets, USP immediately and seek medical care if they experience these symptoms. Do not prescribe Oxycodone and Acetaminophen Tablets, USP for patients with acetaminophen allergy.
Oxycodone is an opioid agonist of the morphine-type. Such drugs are sought by drug abusers and people with addiction disorders and are subject to criminal diversion.
Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing oxycodone and acetaminophen tablets in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Concerns about misuse, addiction, and diversion should not prevent the proper management of pain.
Healthcare professionals should contact their State Professional Licensing Board or State Controlled Substances Authority for information on how to prevent and detect abuse or diversion of this product.
Administration of oxycodone and acetaminophen tablets should be closely monitored for the following potentially serious adverse reactions and complications:
Respiratory depression is a hazard with the use of oxycodone, one of the active ingredients in oxycodone and acetaminophen tablets, as with all opioid agonists. Elderly and debilitated patients are at particular risk for respiratory depression as are non-tolerant patients given large initial doses of oxycodone or when oxycodone is given in conjunction with other agents that depress respiration. Oxycodone should be used with extreme caution in patients with acute asthma, chronic obstructive pulmonary disorder (COPD), cor pulmonale, or preexisting respiratory impairment. In such patients, even usual therapeutic doses of oxycodone may decrease respiratory drive to the point of apnea. In these patients alternative non-opioid analgesics should be considered, and opioids should be employed only under careful medical supervision at the lowest effective dose.
In case of respiratory depression, a reversal agent such as naloxone hydrochloride may be utilized (see OVERDOSAGE).
The respiratory depressant effects of opioids include carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, and may be markedly exaggerated in the presence of head injury, other intracranial lesions or a preexisting increase in intracranial pressure. Oxycodone produces effects on pupillary response and consciousness which may obscure neurologic signs of worsening in patients with head injuries.
Oxycodone may cause severe hypotension particularly in individuals whose ability to maintain blood pressure has been compromised by a depleted blood volume, or after concurrent administration with drugs which compromise vasomotor tone such as phenothiazines. Oxycodone, like all opioid analgesics of the morphine-type, should be administered with caution to patients in circulatory shock, since vasodilation produced by the drug may further reduce cardiac output and blood pressure. Oxycodone may produce orthostatic hypotension in ambulatory patients.
Precaution should be taken in patients with liver disease. Hepatotoxicity and severe hepatic failure occurred in chronic alcoholics following therapeutic doses.
Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products.
The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen.
Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product that contains acetaminophen. Instruct patients to seek medical attention immediately upon ingestion of more than 4000 milligrams of acetaminophen per day, even if they feel well.
Serious skin reactionsRarely, acetaminophen may cause serious skin reactions such as acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. Patients should be informed about the signs of serious skin reactions, and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity.
Hypersensitivity/anaphylaxisThere have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to discontinue Oxycodone and Acetaminophen Tablets, USP immediately and seek medical care if they experience these symptoms. Do not prescribe Oxycodone and Acetaminophen Tablets, USP for patients with acetaminophen allergy.
Respiratory DepressionRespiratory depression is a hazard with the use of oxycodone, one of the active ingredients in oxycodone and acetaminophen tablets, as with all opioid agonists. Elderly and debilitated patients are at particular risk for respiratory depression as are non-tolerant patients given large initial doses of oxycodone or when oxycodone is given in conjunction with other agents that depress respiration. Oxycodone should be used with extreme caution in patients with acute asthma, chronic obstructive pulmonary disorder (COPD), cor pulmonale, or preexisting respiratory impairment. In such patients, even usual therapeutic doses of oxycodone may decrease respiratory drive to the point of apnea. In these patients alternative non-opioid analgesics should be considered, and opioids should be employed only under careful medical supervision at the lowest effective dose.
In case of respiratory depression, a reversal agent such as naloxone hydrochloride may be utilized (see OVERDOSAGE).
Head Injury and Increased Intracranial PressureThe respiratory depressant effects of opioids include carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, and may be markedly exaggerated in the presence of head injury, other intracranial lesions or a preexisting increase in intracranial pressure. Oxycodone produces effects on pupillary response and consciousness which may obscure neurologic signs of worsening in patients with head injuries.
Hypotensive EffectOxycodone may cause severe hypotension particularly in individuals whose ability to maintain blood pressure has been compromised by a depleted blood volume, or after concurrent administration with drugs which compromise vasomotor tone such as phenothiazines. Oxycodone, like all opioid analgesics of the morphine-type, should be administered with caution to patients in circulatory shock, since vasodilation produced by the drug may further reduce cardiac output and blood pressure. Oxycodone may produce orthostatic hypotension in ambulatory patients.
HepatotoxicityPrecaution should be taken in patients with liver disease. Hepatotoxicity and severe hepatic failure occurred in chronic alcoholics following therapeutic doses.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Oxycodone and Acetaminophen Tablets are indicated for the relief of moderate to moderately severe pain.
History
There is currently no drug history available for this drug.
Other Information
Each tablet, for oral administration, contains:
Oxycodone hydrochloride, USP ................................................................. 5 mg
(equivalent to 4.4815 mg of Oxycodone)
Acetaminophen, USP .............................................................................. 325 mg
In addition each tablet contains the following inactive ingredients: crospovidone, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized corn starch, sodium starch glycolate and stearic acid. May also contain corn starch.
Oxycodone, 14-hydroxydihydrocodeinone, is a semisynthetic opioid analgesic which occurs as a white, odorless, crystalline powder having a saline, bitter taste. The molecular formula for oxycodone hydrochloride is C18H21NO4∙HCl and the molecular weight 351.82. It is derived from the opium alkaloid thebaine, and may be represented by the following structural formula:
Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic which occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2 and the molecular weight is 151.17. It may be represented by the following structural formula:
Sources
Oxycodone And Acetaminophen Manufacturers
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Major Pharmaceuticals
![Oxycodone And Acetaminophen (Oxycodone Hydrochloride And Acetaminophen) Tablet [Major Pharmaceuticals]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Oxycodone And Acetaminophen | Major Pharmaceuticals
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Proficient Rx Lp
Oxycodone And Acetaminophen | Proficient Rx Lp
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Direct Rx
Oxycodone And Acetaminophen | County Line Pharmaceuticals, Llc
adults and children 2 years and older apply externally to the affected area up to 3 to 4 times a day children under 2 years ask a doctor -
Direct Rx
Oxycodone And Acetaminophen | Direct Rx
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Mayne Pharma
Oxycodone And Acetaminophen | Conopco Inc. D/b/a Unilever
Directions:
For underarm use only.
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Blenheim Pharmacal, Inc.
Oxycodone And Acetaminophen | Blenheim Pharmacal, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
Tablets -
Blenheim Pharmacal, Inc.
Oxycodone And Acetaminophen | Blenheim Pharmacal, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Rebel Distributors Corp
Oxycodone And Acetaminophen | Rebel Distributors Corp
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 10 mg / 325 mg 6 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Lake Erie Medical Dba Quality Care Products Llc
Oxycodone And Acetaminophen | Lake Erie Medical Dba Quality Care Products Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 7.5 mg / 500 mg 8 Tablets
Oxycodone and Acetaminophen Tablets 10 mg / 650 mg 6 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Bryant Ranch Prepack
Oxycodone And Acetaminophen | Bryant Ranch Prepack
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
Tablets -
Bryant Ranch Prepack
Oxycodone And Acetaminophen | Bryant Ranch Prepack
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 10 mg / 325 mg 6 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Redpharm Drug Inc.
Oxycodone And Acetaminophen | Redpharm Drug Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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H.j. Harkins Company, Inc.
Oxycodone And Acetaminophen | H.j. Harkins Company, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 10 mg / 325 mg 6 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
-
Pd-rx Pharmaceuticals, Inc.
Oxycodone And Acetaminophen | Pd-rx Pharmaceuticals, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
-
Dispensing Solutions, Inc.
Oxycodone And Acetaminophen | Dispensing Solutions, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
Tablets -
Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
Oxycodone And Acetaminophen | Lake Erie Medical Dba Quality Care Products Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and acetaminophen tablets 5 mg/325 mg; Oxycodone and acetaminophen tablets 7.5 mg/500 mg; Oxycodone and acetaminophen tablets 10 mg/650 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and acetaminophen tablets 7.5 mg/325 mg; Oxycodone and acetaminophen tablets 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 5 mg/325 mg 12 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg 8 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/500 mg 8 tablets Oxycodone and Acetaminophen Tablets 10 mg/325 mg 6 tablets Oxycodone and Acetaminophen Tablets 10 mg/650 mg 6 tablets Cessation of Therapy
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Rebel Distributors Corp
Oxycodone And Acetaminophen | Rebel Distributors Corp
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets -
H.j. Harkins Company, Inc.
Oxycodone And Acetaminophen | H.j. Harkins Company, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Lake Erie Medical Dba Quality Care Products Llc
Oxycodone And Acetaminophen | Lake Erie Medical Dba Quality Care Products Llc
DOSAGE AND ADMINISTRATION
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
TabletsCessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
-
Rebel Distributors Corp
Oxycodone And Acetaminophen | Rebel Distributors Corp
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Stat Rx Usa Llc
Oxycodone And Acetaminophen | Stat Rx Usa Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
Tablets -
Pd-rx Pharmaceuticals, Inc.
Oxycodone And Acetaminophen | Pd-rx Pharmaceuticals, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and acetaminophen tablets 5 mg/325 mg; Oxycodone and acetaminophen tablets 7.5 mg/500 mg; Oxycodone and acetaminophen tablets 10 mg/650 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and acetaminophen tablets 7.5 mg/325 mg; Oxycodone and acetaminophen tablets 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 5 mg/325 mg 12 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg 8 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/500 mg 8 tablets Oxycodone and Acetaminophen Tablets 10 mg/325 mg 6 tablets Oxycodone and Acetaminophen Tablets 10 mg/650 mg 6 tablets Cessation of Therapy
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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St Marys Medical Park Pharmacy
Oxycodone And Acetaminophen | Northwind Pharmaceuticals
There is no fixed dosage regimen for the management of hyperglycemia in patients with type 2 diabetes with metformin hydrochloride or any other pharmacologic agent. Dosage of metformin hydrochloride must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily doses. The maximum recommended daily dose of metformin hydrochloride is 2550 mg in adults and 2000 mg in pediatric patients (10 to 16 years of age).
Metformin hydrochloride should be given in divided doses with meals. Metformin hydrochloride should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient.
During treatment initiation and dose titration (see Recommended Dosing Schedule), fasting plasma glucose should be used to determine the therapeutic response to metformin hydrochloride and identify the minimum effective dose for the patient. Thereafter, glycosylated hemoglobin should be measured at intervals of approximately three months. The therapeutic goal should be to decrease both fasting plasma glucose and glycosylated hemoglobin levels to normal or near normal by using the lowest effective dose of metformin hydrochloride, either when used as monotherapy or in combination with sulfonylurea or insulin.
Monitoring of blood glucose and glycosylated hemoglobin will also permit detection of primary failure, i.e., inadequate lowering of blood glucose at the maximum recommended dose of medication, and secondary failure, i.e., loss of an adequate blood glucose lowering response after an initial period of effectiveness.
Short-term administration of metformin hydrochloride may be sufficient during periods of transient loss of control in patients usually well-controlled on diet alone.
Recommended Dosing Schedule
Adults – In general, clinically significant responses are not seen at doses below 1500 mg per day. However, a lower recommended starting dose and gradually increased dosage is advised to minimize gastrointestinal symptoms.
The usual starting dose of metformin hydrochloride is 500 mg twice a day or 850 mg once a day, given with meals. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day, given in divided doses. Patients can also be titrated from 500 mg twice a day to 850 mg twice a day after 2 weeks. For those patients requiring additional glycemic control, metformin hydrochloride may be given to a maximum daily dose of 2550 mg per day. Doses above 2000 mg may be better tolerated given three times a day with meals.
If higher doses of metformin are required, metformin hydrochloride should be used at total daily doses up to 2550 mg administered in divided daily doses, as described above. (See CLINICAL PHARMACOLOGY: Clinical Studies.)
Pediatrics – The usual starting dose of metformin hydrochloride is 500 mg twice a day, given with meals. Dosage increases should be made in increments of 500 mg weekly up to a maximum of 2000 mg per day, given in divided doses.
Transfer From Other Antidiabetic Therapy
When transferring patients from standard oral hypoglycemic agents other than chlorpropamide to metformin hydrochloride, no transition period generally is necessary. When transferring patients from chlorpropamide, care should be exercised during the first two weeks because of the prolonged retention of chlorpropamide in the body, leading to overlapping drug effects and possible hypoglycemia.
Concomitant Metformin Hydrochloride and Oral Sulfonylurea Therapy in Adult Patients
If patients have not responded to four weeks of the maximum dose of metformin hydrochloride monotherapy, consideration should be given to gradual addition of an oral sulfonylurea while continuing metformin hydrochloride at the maximum dose, even if prior primary or secondary failure to a sulfonylurea has occurred. Clinical and pharmacokinetic drug-drug interaction data are currently available only for metformin plus glyburide (glibenclamide).
With concomitant metformin hydrochloride and sulfonylurea therapy, the desired control of blood glucose may be obtained by adjusting the dose of each drug. In a clinical trial of patients with type 2 diabetes and prior failure on glyburide, patients started on metformin hydrochloride 500 mg and glyburide 20 mg were titrated to 1000/20 mg, 1500/20 mg, 2000/20 mg or 2500/20 mg of metformin hydrochloride and glyburide, respectively, to reach the goal of glycemic control as measured by FPG, HbA1c and plasma glucose response (see CLINICAL PHARMACOLOGY: Clinical Studies). However, attempts should be made to identify the minimum effective dose of each drug to achieve this goal. With concomitant metformin hydrochloride and sulfonylurea therapy, the risk of hypoglycemia associated with sulfonylurea therapy continues and may be increased. Appropriate precautions should be taken. (See Package Insert of the respective sulfonylurea.)
If patients have not satisfactorily responded to one to three months of concomitant therapy with the maximum dose of metformin hydrochloride and the maximum dose of an oral sulfonylurea, consider therapeutic alternatives including switching to insulin with or without metformin hydrochloride.
Concomitant Metformin Hydrochloride and Insulin Therapy in Adult Patients
The current insulin dose should be continued upon initiation of metformin hydrochloride therapy. Metformin hydrochloride therapy should be initiated at 500 mg once daily in patients on insulin therapy. For patients not responding adequately, the dose of metformin hydrochloride should be increased by 500 mg after approximately 1 week and by 500 mg every week thereafter until adequate glycemic control is achieved. The maximum recommended daily dose is 2500 mg for metformin hydrochloride. It is recommended that the insulin dose be decreased by 10% to 25% when fasting plasma glucose concentrations decrease to less than 120 mg/dL in patients receiving concomitant insulin and metformin hydrochloride. Further adjustment should be individualized based on glucose-lowering response.
Specific Patient Populations
Metformin hydrochloride is not recommended for use in pregnancy. Metformin hydrochloride is not recommended in patients below the age of 10 years.
The initial and maintenance dosing of metformin hydrochloride should be conservative in patients with advanced age, due to the potential for decreased renal function in this population. Any dosage adjustment should be based on a careful assessment of renal function. Generally, elderly, debilitated, and malnourished patients should not be titrated to the maximum dose of metformin hydrochloride.
Monitoring of renal function is necessary to aid in prevention of lactic acidosis, particularly in the elderly. (See WARNINGS.)
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St Marys Medical Park Pharmacy
Oxycodone And Acetaminophen | St Marys Medical Park Pharmacy
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
Tablets -
Alvogen, Inc.
Oxycodone And Acetaminophen | Alvogen, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and Acetaminophen Tablets are given orally.
Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg 8 Tablets Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg 6 Tablets Cessation of TherapyIn patients treated with Oxycodone and Acetaminophen Tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Bryant Ranch Prepack
Oxycodone And Acetaminophen | Bryant Ranch Prepack
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and Acetaminophen Tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual Adult dosage Maximmum daily dose
Oxycodone and Acetaminophen Tablets, 10 mg/650 mg 1 tablet every 6 hours as needed for pain. 6 Tablets
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Bryant Ranch Prepack
Oxycodone And Acetaminophen | Bryant Ranch Prepack
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and Acetaminophen Tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
STRENGTH USUAL ADULT DOSAGE MAXIMAL DAILY DOSE
Oxycodone and Acetaminophen Tablets, 5mg/325 mg 1 or 2 tablets every 6 12 Tablets
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Bryant Ranch Prepack
Oxycodone And Acetaminophen | Bryant Ranch Prepack
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and Acetaminophen Tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual Adult Dosage Maximal Daily Dose Oxycodone and Acetaminophen Tablets, 2.5mg/325 mg 1 or 2 tablets every 6 hours as needed for pain. 12 Tablets Oxycodone and Acetaminophen Tablets, 5mg/325 mg 1 tablet every 6 hours as needed for pain. 12 Tablets Oxycodone and Acetaminophen Tablets, 7.5 mg/325 mg 1 tablet every 6 hours as needed for pain. 8 Tablets Oxycodone and Acetaminophen Tablets, 7.5 mg/500 mg 1 tablet every 6 hours as needed for pain. 8 Tablets Oxycodone and Acetaminophen Tablets, 10 mg/325 mg 1 tablet every 6 hours as needed for pain. 6 Tablets Oxycodone and Acetaminophen Tablets, 10 mg/650 mg 1 tablet every 6 hours as needed for pain. 6 Tablets Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Bryant Ranch Prepack
Oxycodone And Acetaminophen | Bryant Ranch Prepack
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and acetaminophen tablets 7.5 mg/325 mg:
Cessation of Therapy
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Pd-rx Pharmaceuticals, Inc.
Oxycodone And Acetaminophen | Pd-rx Pharmaceuticals, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and acetaminophen tablets 5 mg/325 mg; Oxycodone and acetaminophen tablets 7.5 mg/500 mg; Oxycodone and acetaminophen tablets 10 mg/650 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and acetaminophen tablets 7.5 mg/325 mg; Oxycodone and acetaminophen tablets 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 5 mg/325 mg 12 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg 8 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/500 mg 8 tablets Oxycodone and Acetaminophen Tablets 10 mg/325 mg 6 tablets Oxycodone and Acetaminophen Tablets 10 mg/650 mg 6 tablets Cessation of Therapy
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Lake Erie Medical Dba Quality Care Product S Llc
Oxycodone And Acetaminophen | Lake Erie Medical Dba Quality Care Product S Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and Acetaminophen Tablets are given orally.
Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg 8 Tablets Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg 6 Tablets Cessation of TherapyIn patients treated with Oxycodone and Acetaminophen Tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Lake Erie Medical Dba Quality Care Products Llc
Oxycodone And Acetaminophen | Lake Erie Medical Dba Quality Care Products Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Lake Erie Medical Dba Quality Care Products Llc
Oxycodone And Acetaminophen | Lake Erie Medical Dba Quality Care Products Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 10 mg / 325 mg 6 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Watson Laboratories, Inc.
Oxycodone And Acetaminophen | Watson Laboratories, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and acetaminophen tablets 5 mg/325 mg; Oxycodone and acetaminophen tablets 7.5 mg/500 mg; Oxycodone and acetaminophen tablets 10 mg/650 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and acetaminophen tablets 7.5 mg/325 mg; Oxycodone and acetaminophen tablets 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 5 mg/325 mg 12 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg 8 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/500 mg 8 tablets Oxycodone and Acetaminophen Tablets 10 mg/325 mg 6 tablets Oxycodone and Acetaminophen Tablets 10 mg/650 mg 6 tablets Cessation of Therapy
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Lake Erie Medical Dba Quality Care Products Llc
Oxycodone And Acetaminophen | Lake Erie Medical Dba Quality Care Products Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
Tablets -
Qualitest Pharmaceuticals
Oxycodone And Acetaminophen | Qualitest Pharmaceuticals
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one or 2 tablets every 6 hours. The maximal daily dose of oxycodone and acetaminophen 2.5 mg/325 mg is 12 tablets. The total daily dose of acetaminophen should not exceed 4 grams.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Qualitest Pharmaceuticals
Oxycodone And Acetaminophen | Mylan Pharmaceuticals Inc.
2.1 Initial DosingFentanyl transdermal system should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.
Due to the risk of respiratory depression, fentanyl transdermal system is only indicated for use in patients who are already opioid-tolerant. Discontinue or taper all other extended-release opioids when beginning fentanyl transdermal system therapy. As fentanyl transdermal system is only for use in opioid-tolerant patients, do not begin any patient on fentanyl transdermal system as the first opioid.
Patients considered opioid-tolerant are those who are taking at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid for a week or longer.
Initiate the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience and risk factors for addiction, abuse, and misuse [see Warnings and Precautions (5.1)]. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with fentanyl transdermal system when serum concentrations from the initial patch will peak [see Warnings and Precautions (5.2)].
The recommended starting dose when converting from other opioids to fentanyl transdermal system is intended to minimize the potential for overdosing patients with the first dose.
Discontinue all other around-the-clock opioid drugs when fentanyl transdermal system therapy is initiated.
While there are useful tables of opioid equivalents readily available, there is substantial interpatient variability in the relative potency of different opioid drugs and products. As such, it is preferable to underestimate a patient’s 24-hour fentanyl requirements and provide rescue medication (i.e., immediate-release opioid) than to overestimate the 24-hour fentanyl requirements which could result in adverse reactions. In a fentanyl transdermal system clinical trial, patients were converted from their prior opioid to fentanyl transdermal system using Table 1 as a guide for the initial fentanyl transdermal system dose.
Consider the following when using the information in Table 1:
• This is not a table of equianalgesic doses. • The conversion doses in this table are only for the conversion from one of the listed oral or parenteral opioid analgesics to fentanyl transdermal system. • The table cannot be used to convert from fentanyl transdermal system to another opioid. Doing so will result in an overestimation of the dose of the new opioid and may result in fatal overdose.To convert patients from oral or parenteral opioids to fentanyl transdermal system, use Table 1. Do not use Table 1 to convert from fentanyl transdermal system to other therapies because this conversion to fentanyl transdermal system is conservative and will overestimate the dose of the new agent.
Table 1*: DOSE CONVERSION TO FENTANYL TRANSDERMAL SYSTEM Alternatively, for adult and pediatric patients taking opioids or doses not listed in Table 1, use the conversion methodology outlined above with Table 2. * Table 1 should not be used to convert from fentanyl transdermal system to other therapies because this conversion to fentanyl transdermal system is conservative. Use of Table 1 for conversion to other analgesic therapies can overestimate the dose of the new agent. Overdosage of the new analgesic agent is possible [see Dosage and Administration (2.3)].Current Analgesic
Daily Dosage (mg/day)
Oral morphine
60 to 134
135 to 224
225 to 314
315 to 404
Intramuscular or Intravenous morphine
10 to 22
23 to 37
38 to 52
53 to 67
Oral oxycodone
30 to 67
67.5 to 112
112.5 to 157
157.5 to 202
Oral codeine
150 to 447
Oral hydromorphone
8 to 17
17.1 to 28
28.1 to 39
39.1 to 51
Intravenous hydromorphone
1.5 to 3.4
3.5 to 5.6
5.7 to 7.9
8 to 10
Intramuscular meperidine
75 to 165
166 to 278
279 to 390
391 to 503
Oral methadone
20 to 44
45 to 74
75 to 104
105 to 134
⇓
⇓
⇓
⇓
Recommended Fentanyl Transdermal System Dose
25 mcg/hour
50 mcg/hour
75 mcg/hour
100 mcg/hour
Alternatively, for adult and pediatric patients taking opioids or doses not listed in Table 1, use the following methodology:
1. Calculate the previous 24-hour analgesic requirement. 2. Convert this amount to the equianalgesic oral morphine dose using a reliable reference.Refer to Table 2 for the range of 24-hour oral morphine doses that are recommended for conversion to each fentanyl transdermal system dose. Use this table to find the calculated 24-hour morphine dose and the corresponding fentanyl transdermal system dose. Initiate fentanyl transdermal system treatment using the recommended dose and titrate patients upwards (no more frequently than 3 days after the initial dose and every 6 days thereafter) until analgesic efficacy is attained.
3. Do not use Table 2 to convert from fentanyl transdermal system to other therapies because this conversion to fentanyl transdermal system is conservative and will overestimate the dose of the new agent. Table 2*: RECOMMENDED INITIAL FENTANYL TRANSDERMAL SYSTEM DOSE BASED UPON DAILY ORAL MORPHINE DOSE NOTE: In clinical trials, these ranges of daily oral morphine doses were used as a basis for conversion to fentanyl transdermal system. * Table 2 should not be used to convert from fentanyl transdermal system to other therapies because this conversion to fentanyl transdermal system is conservative. Use of Table 2 for conversion to other analgesic therapies can overestimate the dose of the new agent. Overdosage of the new analgesic agent is possible [see Dosage and Administration (2.5)].Oral 24 hour
Morphine
(mg/day)
Fentanyl Transdermal System
Dose
(mcg/hour)
60 to 134
25
135 to 224
50
225 to 314
75
315 to 404
100
405 to 494
125
495 to 584
150
585 to 674
175
675 to 764
200
765 to 854
225
855 to 944
250
945 to 1034
275
1035 to 1124
300
For delivery rates in excess of 100 mcg/hour, multiple systems may be used.
For patients that may be more sensitive to the effects of opioids, additional intermediate strengths may be considered during conversion from prior opioids or titrating the dose of the fentanyl transdermal system. For example, rather than converting or titrating to a 50 mcg/hr system, a 37.5 mcg/hr system is available. Similarly a 62.5 mcg/hr system is available for use as an intermediate strength between the 50 mcg/hr and the 75 mcg/hr system, and an 87.5 mcg/hr system is available as an intermediate strength between the 75 mcg/hr system and the 100 mcg/hr system.
The additional intermediate strengths, 32.5 mcg/hr, 62.5 mcg/hr and 87.5 mcg/hr, were not used in the clinical studies.
Hepatic ImpairmentAvoid the use of fentanyl transdermal system in patients with severe hepatic impairment. In patients with mild to moderate hepatic impairment, start with one half of the usual dosage of fentanyl transdermal system. Closely monitor for signs of sedation and respiratory depression, including at each dosage increase [see Warnings and Precautions (5.14), Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].
Renal ImpairmentAvoid the use of fentanyl transdermal system in patients with severe renal impairment. In patients with mild to moderate renal impairment, start with one half of the usual dosage of fentanyl transdermal system. Closely monitor for signs of sedation and respiratory depression, including at each dosage increase [see Warnings and Precautions (5.15), Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].
2.2 Titration and Maintenance of TherapyIndividually titrate fentanyl transdermal system to a dose that provides adequate analgesia and minimizes adverse reactions. Continually reevaluate patients receiving fentanyl transdermal system to assess the maintenance of pain control and the relative incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse. Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration. During chronic therapy, periodically reassess the continued need for opioid analgesics.
The dosing interval for fentanyl transdermal system is 72 hours. Do not increase the fentanyl transdermal system dose for the first time until at least 3 days after the initial application. Titrate the dose based on the daily dose of supplemental opioid analgesics required by the patient on the second or third day of the initial application.
It may take up to 6 days for fentanyl levels to reach equilibrium on a new dose [see Clinical Pharmacology (12.3)]. Therefore, evaluate patients for further titration after no less than two 3‑day applications before any further increase in dosage is made.
Base dosage increments on the daily dosage of supplementary opioids, using the ratio of 45 mg/24 hours of oral morphine to a 12 mcg/hour increase in fentanyl transdermal system dose.
If unacceptable opioid-related adverse reactions are observed, the subsequent doses may be reduced. Adjust the dose to obtain an appropriate balance between management of pain and opioid-related adverse reactions.
A small proportion of adult patients may not achieve adequate analgesia using a 72-hour dosing interval and may require systems to be applied at 48 hours rather than at 72 hours, only if adequate pain control cannot be achieved using a 72-hour regimen. An increase in the fentanyl transdermal system dose should be evaluated before changing dosing intervals in order to maintain patients on a 72-hour regimen.
Dosing intervals less than every 72 hours were not studied in children and adolescents and are not recommended.
2.3 Administration of Fentanyl Transdermal SystemFentanyl transdermal system patches are for transdermal use, only.
Proper handling of fentanyl transdermal system is necessary in order to prevent serious adverse outcomes, including death, associated with accidental secondary exposure to fentanyl transdermal system [see Warnings and Precautions (5.3)].
Application and Handling Instructions
• Patients should apply fentanyl transdermal system to intact, non-irritated, and non-irradiated skin on a flat surface such as the chest, back, flank, or upper arm. In young children and persons with cognitive impairment, adhesion should be monitored and the upper back is the preferred location to minimize the potential of inappropriate patch removal. Hair at the application site may be clipped (not shaved) prior to system application. If the site of fentanyl transdermal system application must be cleansed prior to application of the patch, do so with clear water. Do not use soaps, oils, lotions, alcohol, or any other agents that might irritate the skin or alter its characteristics. Allow the skin to dry completely prior to patch application. • Patients should apply fentanyl transdermal system immediately upon removal from the sealed package. The patch must not be altered (i.e., cut) in any way prior to application. Fentanyl transdermal system should not be used if the pouch seal is broken or if the patch is cut or damaged. • The transdermal system is pressed firmly in place with the palm of the hand for 30 seconds, making sure the contact is complete, especially around the edges. • Each fentanyl transdermal system patch may be worn continuously for 72 hours. The next patch is applied to a different skin site after removal of the previous transdermal system. • If problems with adhesion of the fentanyl transdermal system patch occur, the edges of the patch may be taped with first aid tape. If problems with adhesion persist, the patch may be overlayed with a transparent adhesive film dressing (i.e., BIOCLUSIVE® or Askina®Derm). • If the patch falls off before 72 hours, dispose of it by folding in half and flushing down the toilet. A new patch may be applied to a different skin site. • Patients (or caregivers who apply fentanyl transdermal system) should wash their hands immediately with soap and water after applying fentanyl transdermal system. • Contact with unwashed or unclothed application sites can result in secondary exposure to fentanyl transdermal system and should be avoided. Examples of accidental exposure include transfer of a fentanyl transdermal system patch from an adult’s body to a child while hugging, sharing the same bed as the patient, accidental sitting on a patch and possible accidental exposure of a caregiver’s skin to the medication in the patch while applying or removing the patch. • Instruct patients, family members, and caregivers to keep patches in a secure location out of the reach of children and of others for whom fentanyl transdermal system was not prescribed. Avoidance of HeatInstruct patients to avoid exposing the fentanyl transdermal system application site and surrounding area to direct external heat sources, such as heating pads or electric blankets, heat or tanning lamps, sunbathing, hot baths, saunas, hot tubs, and heated water beds, while wearing the system [see Warnings and Precautions (5.11)].
2.4 Disposal InstructionsFailure to properly dispose of fentanyl transdermal system has resulted in accidental exposures and deaths [see Warnings and Precautions (5.3)].
Patients should dispose of used patches immediately upon removal by folding the adhesive side of the patch to itself, then flushing down the toilet.
Unused patches should be removed from their pouches, the protective liners removed, the patches folded so that the adhesive side of the patch adheres to itself, and immediately flushed down the toilet.
Patients should dispose of any patches remaining from a prescription as soon as they are no longer needed.
2.5 Discontinuation of Fentanyl Transdermal SystemSignificant amounts of fentanyl continue to be absorbed from the skin for 24 hours or more after the patch is removed [see Clinical Pharmacology (12.3)].
To convert patients to another opioid, remove fentanyl transdermal system and titrate the dose of the new analgesic based upon the patient’s report of pain until adequate analgesia has been attained. Upon system removal, 17 hours or more are required for a 50% decrease in serum fentanyl concentrations. Withdrawal symptoms are possible in some patients after conversion or dose adjustment [see Warnings and Precautions (5.17)].
Do not use Tables 1 and 2 to convert from fentanyl transdermal system to other therapies to avoid overestimating the dose of the new agent resulting in overdose of the new analgesic and possibly death.
When discontinuing fentanyl transdermal system and not converting to another opioid, use a gradual downward titration, such as halving the dose every 6 days, in order to reduce the possibility of withdrawal symptoms [see Warnings and Precautions (5.17)]. It is not known at what dose level fentanyl transdermal system may be discontinued without producing the signs and symptoms of opioid withdrawal.
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Watson Laboratories, Inc.
Oxycodone And Acetaminophen | Watson Laboratories, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. However, it should be kept in mind that tolerance to oxycodone can develop with continued use and that the incidence of untoward effects is dose related. This product is inappropriate even in high doses for severe or intractable pain.
Oxycodone and acetaminophen capsules are given orally. The usual adult dosage is one capsule every 6 hours as needed for pain.
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Amneal Pharmaceuticals, Llc
Oxycodone And Acetaminophen | Glaxosmithkline Llc
2.1 Dosing InformationThe recommended dose of IMITREX Tablets is 25 mg, 50 mg, or 100 mg. Doses of 50 mg and 100 mg may provide a greater effect than the 25-mg dose, but doses of 100 mg may not provide a greater effect than the 50-mg dose. Higher doses may have a greater risk of adverse reactions [see Clinical Studies (14)].
If the migraine has not resolved by 2 hours after taking IMITREX Tablets, or returns after a transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose is 200 mg in a 24-hour period.
Use after IMITREX Injection: If the migraine returns following an initial treatment with IMITREX (sumatriptan succinate) Injection, additional single IMITREX Tablets (up to 100 mg/day) may be given with an interval of at least 2 hours between tablet doses.
The safety of treating an average of more than 4 headaches in a 30-day period has not been established.
2.2 Dosing in Patients With Hepatic ImpairmentIf treatment is deemed advisable in the presence of mild to moderate hepatic impairment, the maximum single dose should not exceed 50 mg [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].
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Amneal Pharmaceuticals, Llc
Oxycodone And Acetaminophen | Amneal Pharmaceuticals Of New York, Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 10 mg / 325 mg 6 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Amneal Pharmaceuticals, Llc
Oxycodone And Acetaminophen | Amneal Pharmaceuticals, Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 7.5 mg / 500 mg 8 Tablets
Oxycodone and Acetaminophen Tablets 10 mg / 650 mg 6 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Mallinckrodt, Inc.
Oxycodone And Acetaminophen | Mallinckrodt, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. However, it should be kept in mind that tolerance to oxycodone can develop with continued use and that the incidence of untoward effects is dose related. This product is inappropriate even in high doses for severe or intractable pain. Oxycodone and acetaminophen capsules are given orally.
The usual adult dosage is one capsule every 6 hours as needed for pain.
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Aurolife Pharma Llc
Oxycodone And Acetaminophen | Aurolife Pharma Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and Acetaminophen Tablets, USP 2.5 mg/325 mg
The usual adult dosage is one or two tablets every 6 hours. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets, USP 5 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets, USP 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets, USP 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength
Maximal Daily Dose
Oxycodone and Acetaminophen Tablets, USP 2.5 mg/325 mg
12 Tablets
Oxycodone and Acetaminophen Tablets, USP 5 mg/325 mg
12 Tablets
Oxycodone and Acetaminophen Tablets, USP 7.5 mg/325 mg
8 Tablets
Oxycodone and Acetaminophen Tablets, USP 10 mg/325 mg
6 Tablets
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Apotheca, Inc
Oxycodone And Acetaminophen | Apotheca, Inc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Physicians Total Care, Inc.
Oxycodone And Acetaminophen | Physicians Total Care, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual
Adult Dosage Maximal
Daily Dose Oxycodone and acetaminophen tablets
5 mg/325 mg 1 tablet every 6 hours
as needed for pain 12
Tablets Oxycodone and acetaminophen tablets
7.5 mg/325 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
7.5 mg/500 mg 1 tablet every 6 hours
as needed for pain 8
Tablets Oxycodone and acetaminophen tablets
10 mg/325 mg 1 tablet every 6 hours
as needed for pain 6
Tablets -
American Health Packaging
Oxycodone And Acetaminophen | American Health Packaging
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and acetaminophen tablets 5 mg/325 mg; Oxycodone and acetaminophen tablets 7.5 mg/500 mg; Oxycodone and acetaminophen tablets 10 mg/650 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and acetaminophen tablets 7.5 mg/325 mg; Oxycodone and acetaminophen tablets 10 mg/325 mg
Strength Maximal Daily Dose
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and Acetaminophen Tablets 5 mg/325 mg
12 tablets
Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg
8 tablets
Oxycodone and Acetaminophen Tablets 7.5 mg/500 mg
8 tablets
Oxycodone and Acetaminophen Tablets 10 mg/325 mg
6 tablets
Oxycodone and Acetaminophen Tablets 10 mg/650 mg
6 tablets
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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American Health Packaging
Oxycodone And Acetaminophen | American Health Packaging
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Caraco Pharmaceutical Laboratories, Ltd.
Oxycodone And Acetaminophen | Caraco Pharmaceutical Laboratories, Ltd.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and Acetaminophen Tablets, USP 2.5 mg/325 mg
The usual adult dosage is 2 tablets every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and Acetaminophen Tablets, USP 5 mg/325 mg;
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and Acetaminophen Tablets, USP 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets, USP 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen 2.5 mg/325 mg 12 Tablets Oxycodone and Acetaminophen 5 mg/325 mg 12 Tablets Oxycodone and Acetaminophen 7.5 mg/325 mg 8 Tablets Oxycodone and Acetaminophen 10 mg/325 mg 6 Tablets Cessation of Therapy
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Pd-rx Pharmaceuticals, Inc.
Oxycodone And Acetaminophen | Pd-rx Pharmaceuticals, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Roxane Laboratories, Inc.
Oxycodone And Acetaminophen | Roxane Laboratories, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and Acetaminophen Tablets:The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. (Maximum daily dose is 12 tablets.)
Cessation of TherapyIn patients treated with oxycodone and acetaminophen for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Unit Dose Services
Oxycodone And Acetaminophen | Unit Dose Services
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. Oxycodone and acetaminophen tablets 5 mg/325 mg; Oxycodone and acetaminophen tablets 7.5 mg/500 mg; Oxycodone and acetaminophen tablets 10 mg/650 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. Oxycodone and acetaminophen tablets 7.5 mg/325 mg; Oxycodone and acetaminophen tablets 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 5 mg/325 mg 12 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg 8 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/500 mg 8 tablets Oxycodone and Acetaminophen Tablets 10 mg/325 mg 6 tablets Oxycodone and Acetaminophen Tablets 10 mg/650 mg 6 tablets Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Unit Dose Services
Oxycodone And Acetaminophen | Unit Dose Services
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. Oxycodone and acetaminophen tablets 5 mg/325 mg; Oxycodone and acetaminophen tablets 7.5 mg/500 mg; Oxycodone and acetaminophen tablets 10 mg/650 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. Oxycodone and acetaminophen tablets 7.5 mg/325 mg; Oxycodone and acetaminophen tablets 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 5 mg/325 mg 12 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg 8 tablets Oxycodone and Acetaminophen Tablets 7.5 mg/500 mg 8 tablets Oxycodone and Acetaminophen Tablets 10 mg/325 mg 6 tablets Oxycodone and Acetaminophen Tablets 10 mg/650 mg 6 tablets Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
-
Unit Dose Services
Oxycodone And Acetaminophen | Unit Dose Services
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and Acetaminophen Tablets 2.5 mg/325 mg
The usual adult dosage is one or 2 tablets every 6 hours. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets 5 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 12 Tablets 2.5 mg/325 mg Oxycodone and Acetaminophen Tablets 12 Tablets 5 mg/325 mg Oxycodone and Acetaminophen Tablets 8 Tablets 7.5 mg/325 mg Oxycodone and Acetaminophen Tablets 6 Tablets 10 mg/325 mg Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Mylan Pharmaceuticals Inc.
Oxycodone And Acetaminophen | Mylan Pharmaceuticals Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual Adult Dosage Maximal Daily Dose Oxycodone and Acetaminophen Tablets, 2.5 mg/325 mg 1 or 2 tablets every 6 hours as needed for pain. 12 Tablets Oxycodone and Acetaminophen Tablets, 5 mg/325 mg 1 tablet every 6 hours as needed for pain. 12 Tablets Oxycodone and Acetaminophen Tablets, 7.5 mg/325 mg 1 tablet every 6 hours as needed for pain. 8 Tablets Oxycodone and Acetaminophen Tablets, 10 mg/325 mg 1 tablet every 6 hours as needed for pain. 6 Tablets Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Midlothian Laboratories
Oxycodone And Acetaminophen | Midlothian Laboratories
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The total daily dose of acetaminophen should not exceed 4 grams.
Strength Usual Adult Dosage Maximal Daily Dose Oxycodone and Acetaminophen Tablets, 5 mg/325 mg 1 tablet every 6 hours as needed for pain. 12 Tablets Oxycodone and Acetaminophen Tablets, 7.5 mg/325 mg 1 tablet every 6 hours as needed for pain. 8 Tablets Oxycodone and Acetaminophen Tablets, 10 mg/325 mg 1 tablet every 6 hours as needed for pain. 6 Tablets Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Mallinckrodt, Inc.
Oxycodone And Acetaminophen | Merck Sharp & Dohme Corp.
2.1 AsthmaSINGULAIR should be taken once daily in the evening. The following doses are recommended:
For adults and adolescents 15 years of age and older: one 10-mg tablet.
For pediatric patients 6 to 14 years of age: one 5-mg chewable tablet.
For pediatric patients 2 to 5 years of age: one 4-mg chewable tablet or one packet of 4-mg oral granules.
For pediatric patients 12 to 23 months of age: one packet of 4-mg oral granules.
Safety and effectiveness in pediatric patients less than 12 months of age with asthma have not been established.
There have been no clinical trials in patients with asthma to evaluate the relative efficacy of morning versus evening dosing. The pharmacokinetics of montelukast are similar whether dosed in the morning or evening. Efficacy has been demonstrated for asthma when montelukast was administered in the evening without regard to time of food ingestion.
2.2 Exercise-Induced Bronchoconstriction (EIB)For prevention of EIB, a single dose of SINGULAIR should be taken at least 2 hours before exercise. The following doses are recommended:
For adults and adolescents 15 years of age and older: one 10-mg tablet.
For pediatric patients 6 to 14 years of age: one 5-mg chewable tablet.
An additional dose of SINGULAIR should not be taken within 24 hours of a previous dose. Patients already taking SINGULAIR daily for another indication (including chronic asthma) should not take an additional dose to prevent EIB. All patients should have available for rescue a short-acting β-agonist. Safety and efficacy in patients younger than 6 years of age have not been established. Daily administration of SINGULAIR for the chronic treatment of asthma has not been established to prevent acute episodes of EIB.
2.3 Allergic RhinitisFor allergic rhinitis, SINGULAIR should be taken once daily. Efficacy was demonstrated for seasonal allergic rhinitis when montelukast was administered in the morning or the evening without regard to time of food ingestion. The time of administration may be individualized to suit patient needs.
The following doses for the treatment of symptoms of seasonal allergic rhinitis are recommended:
For adults and adolescents 15 years of age and older: one 10-mg tablet.
For pediatric patients 6 to 14 years of age: one 5-mg chewable tablet.
For pediatric patients 2 to 5 years of age: one 4-mg chewable tablet or one packet of 4-mg oral granules.
Safety and effectiveness in pediatric patients younger than 2 years of age with seasonal allergic rhinitis have not been established.
The following doses for the treatment of symptoms of perennial allergic rhinitis are recommended:
For adults and adolescents 15 years of age and older: one 10-mg tablet.
For pediatric patients 6 to 14 years of age: one 5-mg chewable tablet.
For pediatric patients 2 to 5 years of age: one 4-mg chewable tablet or one packet of 4-mg oral granules.
For pediatric patients 6 to 23 months of age: one packet of 4-mg oral granules.
Safety and effectiveness in pediatric patients younger than 6 months of age with perennial allergic rhinitis have not been established.
2.4 Asthma and Allergic RhinitisPatients with both asthma and allergic rhinitis should take only one SINGULAIR dose daily in the evening.
2.5 Instructions for Administration of Oral GranulesSINGULAIR 4-mg oral granules can be administered either directly in the mouth, dissolved in 1 teaspoonful (5 mL) of cold or room temperature baby formula or breast milk, or mixed with a spoonful of cold or room temperature soft foods; based on stability studies, only applesauce, carrots, rice, or ice cream should be used. The packet should not be opened until ready to use. After opening the packet, the full dose (with or without mixing with baby formula, breast milk, or food) must be administered within 15 minutes. If mixed with baby formula, breast milk, or food, SINGULAIR oral granules must not be stored for future use. Discard any unused portion. SINGULAIR oral granules are not intended to be dissolved in any liquid other than baby formula or breast milk for administration. However, liquids may be taken subsequent to administration. SINGULAIR oral granules can be administered without regard to the time of meals.
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Pd-rx Pharmaceuticals, Inc.
Oxycodone And Acetaminophen | West-ward Pharmaceutical Corp
Prior to initiating testosterone cypionate, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these serum testosterone concentrations are below the normal range.
Testosterone cypionate injection is for intramuscular use only.
It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle.
The suggested dosage for testosterone cypionate injection varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient's response and the appearance of adverse reactions.
Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose.
For replacement in the hypogonadal male, 50 to 400 mg should be administered every two to four weeks.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.
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Barr Laboratories Inc.
Oxycodone And Acetaminophen | Barr Laboratories Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen capsules are given orally.
The usual adult dosage is one capsule every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen capsules for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Alvogen, Inc.
Oxycodone And Acetaminophen | Alvogen, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and Acetaminophen Tablets are given orally.
Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg 8 Tablets Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg 6 Tablets Cessation of TherapyIn patients treated with Oxycodone and Acetaminophen Tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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American Health Packaging
Oxycodone And Acetaminophen | American Health Packaging
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and Acetaminophen Tablets are given orally.
Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily DoseOxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg
8 Tablets
Oxycodone and Acetaminophen Tablets, USP, 10 mg/325 mg
6 Tablets
Cessation of TherapyIn patients treated with Oxycodone and Acetaminophen Tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Qualitest Pharmaceuticals
Oxycodone And Acetaminophen | Qualitest Pharmaceuticals
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Pd-rx Pharmaceuticals, Inc.
Oxycodone And Acetaminophen | Pd-rx Pharmaceuticals, Inc.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and Acetaminophen Tablets 2.5 mg/325 mg
The usual adult dosage is one or 2 tablets every 6 hours. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets 5 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 12 Tablets 2.5 mg/325 mg Oxycodone and Acetaminophen Tablets 12 Tablets 5 mg/325 mg Oxycodone and Acetaminophen Tablets 8 Tablets 7.5 mg/325 mg Oxycodone and Acetaminophen Tablets 6 Tablets 10 mg/325 mg Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Amneal Pharmaceuticals Of New York, Llc
Oxycodone And Acetaminophen | Carlsbad Technology, Inc.
Carefully consider the potential benefits and risks of diclofenac sodium delayed-release tablets and other treatment options before deciding to use diclofenac. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals [see Warnings].
After observing the response to initial therapy with diclofenac, the dose and frequency should be adjusted to suit an individual patient's needs.
For the relief of osteoarthritis, the recommended dosage is 100 to 150 mg/day in divided doses (50 mg b.i.d. or t.i.d., or 75 mg b.i.d.).
For the relief of rheumatoid arthritis, the recommended dosage is 150 to 200 mg/day in divided doses (50 mg t.i.d. or q.i.d., or 75 mg b.i.d.).
For the relief of ankylosing spondylitis, the recommended dosage is 100 to 125 mg/day, administered as 25 mg q.i.d., with an extra 25-mg dose at bedtime if necessary.
Different formulations of diclofenac (diclofenac sodium delayed-release tablets; diclofenac sodium extended-release tablets; diclofenac potassium immediate-release tablets) are not necessarily bioequivalent even if the milligram strength is the same.
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Actavis Elizabeth Llc
Oxycodone And Acetaminophen | Actavis Elizabeth Llc
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and Acetaminophen Tablets 2.5 mg/325 mg
The usual adult dosage is one or 2 tablets every 6 hours. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets 5 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Oxycodone and Acetaminophen Tablets 7.5 mg/325 mg; Oxycodone and Acetaminophen Tablets 10 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets 12 Tablets 2.5 mg/325 mg Oxycodone and Acetaminophen Tablets 12 Tablets 5 mg/325 mg Oxycodone and Acetaminophen Tablets 8 Tablets 7.5 mg/325 mg Oxycodone and Acetaminophen Tablets 6 Tablets 10 mg/325 mg Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Rhodes Pharmaceuticals L.p.
Oxycodone And Acetaminophen | Rhodes Pharmaceuticals L.p.
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
Oxycodone and Acetaminophen Tablets, USP, 5 mg/325 mg
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.Oxycodone and Acetaminophen Tablets, USP, 7.5 mg/325 mg; 10 mg/325 mg
Strength Maximal Daily Dose Oxycodone and Acetaminophen Tablets
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
5 mg/325 mg 12 Tablets Oxycodone and Acetaminophen Tablets
7.5 mg/325 mg 8 Tablets Oxycodone and Acetaminophen Tablets
10 mg/325 mg 6 Tablets Cessation of TherapyIn patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Mikart, Inc.
Oxycodone And Acetaminophen | Tmig, Inc.
Active Duodenal Ulcer
The current recommended adult oral dosage of ranitidine for duodenal ulcer is 150 mg twice daily. An alternative dosage of 300 mg once daily after the evening meal or at bedtime can be used for patients in whom dosing convenience is important. The advantages of one treatment regimen compared to the other in a particular patient population have yet to be demonstrated (see CLINICAL PHARMACOLOGY: CLINICAL TRIALS: ACTIVE DUODENAL ULCER). Smaller doses have been shown to be equally effective in inhibiting gastric acid secretion in US studies, and several foreign trials have shown that 100 mg twice daily is as effective as the 150 mg dose.Antacid should be given as needed for relief of pain (see CLINICAL PHARMACOLOGY: PHARMACOKINETICS).
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Medsource Pharmaceuticals
Oxycodone And Acetaminophen | Medsource Pharmaceuticals
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids.
If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally.
The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose
Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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Directrx
Oxycodone And Acetaminophen | Directrx
Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams. The maximal daily dose of oxycodone and acetaminophen 5 mg/325 mg is 12 tablets.
Cessation of Therapy
In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
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