Perform

Adults / Children 12 years and older:  Apply on to affected area up to 4 times daily Children under 12 years of age:  Consult a physician

Directions:

Adults / Children 12 years and older:  Spray on to affected area up to 4 times daily Children under 12 years of age:  Consult a physician

Adults and Children 2 years and older: Spray on to affected area up to 4 times daily Children under 2 years of age: Consult a physician

Generally, when estrogen is prescribed for a postmenopausal woman with a uterus, a progestin should also be considered to reduce the risk of endometrial cancer.

A woman without a uterus does not need a progestin. In some cases, however, hysterectomized women with a history of endometriosis may need a progestin [see Warnings and Precautions (5.3,5.15)].

Use of estrogen-alone, or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Postmenopausal women should be re-evaluated periodically as clinically appropriate to determine if treatment is still necessary.

2.1 Treatment of Atrophic Vaginitis due to Menopause

Estradiol vaginal inserts should be administered intravaginally using the supplied applicator: 1 tablet daily for 2 weeks, followed by 1 tablet twice weekly (for example, Tuesday and Friday). Generally, women should be started at the 10 mcg dosage strength.

Adults / Children 12 years and older:  Apply on to affected area up to 4 times daily Children under 12 years of age:  Consult a physician

Adults and Children 2 years and older: Massage onto affected area up to 4 times daily Children under 2 years of age:  Consult physician

Adults and Children 2 years and older: Roll on the affected area up to 4 times daily Children under 2 years of age: Consult a physician