Petrem Recall

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FDA Labeling Changes

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Other Information

Inhalation Anesthetic For Use in Dogs

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Petrem® (sevoflurane, USP), a volatile liquid, is a halogenated general inhalation anesthetic drug. Its chemical name is fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether, and its structural formula is:


Sevoflurane Physical Constants are:

Molecular weight                                  200.05

Boiling point at 760 mm Hg                   58.6°C

Specific gravity at 20°C                        1.520-1.525 g/mL

Vapor pressure in mm Hg at 20°C         157

                                      at 25°C         197

                                      at 36°C         317

Distribution Partition Coefficients at 37°C:

Blood/Gas                                             0.63-0.69

Water/Gas                                             0.36

Olive Oil/Gas                                         47-54

Brain/Gas                                              1.15

Mean Component/Gas Partition Coefficients at 25°C for Polymers Used Commonly in Medical Applications:

Conductive rubber                                14.0

Butyl rubber                                         7.7

Polyvinyl chloride                                 17.4

Polyethylene                                        1.3

Sevoflurane is nonflammable and nonexplosive as defined by the requirements of International Electrotechnical Commission 601-2-13.

Sevoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Sevoflurane is nonpungent. It is miscible with ethanol, ether, chloroform and petroleum benzene, and it is slightly soluble in water. Sevoflurane is stable when stored under normal room lighting condition according to instructions.

Petrem Manufacturers

  • Piramal Critical Care Inc
    Petrem (Sevoflurane) Liquid [Piramal Critical Care Inc]

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