Phenylephrine Hydrochloride

Phenylephrine Hydrochloride

Phenylephrine Hydrochloride Recall

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Questions & Answers

Side Effects & Adverse Reactions

If used in conjunction with oxytocic drugs, the pressor effect of sympathomimetic pressor amines is potentiated (see PRECAUTIONS, Drug Interactions). The obstetrician should be warned that some oxytocic drugs may cause severe persistent hypertension and that even a rupture of a cerebral blood vessel may occur during the postpartum period.

This product contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Phenylephrine Hydrochloride Injection is intended for the maintenance of an adequate level of blood pressure during spinal and inhalation anesthesia and for the treatment of vascular failure in shock, shock-like states and drug induced hypotension or hypersensitivity. It is also employed to overcome paroxysmal supraventricular tachycardia, to prolong spinal anesthesia and as a vasoconstrictor in regional analgesia.

History

There is currently no drug history available for this drug.

Other Information

Phenylephrine hydrochloride is a vasoconstrictor and pressor drug chemically related to epinephrine and ephedrine. Phenylephrine hydrochloride is a synthetic sympathomimetic agent in sterile form for parenteral injection. Chemically, phenylephrine hydrochloride is (-)-m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol hydrochloride, and has the following structural formula:

Structural Formula

Each mL contains: Phenylephrine Hydrochloride 10 mg; Sodium Chloride 3.5 mg; Sodium Citrate Dihydrate 4 mg; Citric Acid Monohydrate 1 mg; Sodium Metabisulfite 2 mg; Water for Injection q.s. pH adjusted with Sodium Hydroxide and/or Hydrochloric Acid if necessary. pH 3.0-6.5.

Phenylephrine Hydrochloride Manufacturers


  • Baxter Healthcare Corporation
    Phenylephrine Hydrochloride Injection [Baxter Healthcare Corporation]
  • General Injectables & Vaccines
    Phenylephrine Hydrochloride Injection, Solution [General Injectables & Vaccines]
  • West-ward Pharmaceutical Corp.
    Phenylephrine Hydrochloride Injection [West-ward Pharmaceutical Corp.]
  • American Regent, Inc.
    Phenylephrine Hydrochloride Injection, Solution [American Regent, Inc.]
  • Sandoz Inc.
    Phenylephrine Hydrochloride Injection, Solution [Sandoz Inc.]
  • Falcon Laboratory Ltd
    Phenylephrine Hydrochloride (Phenylephrine Hydrochloride) Solution [Falcon Laboratory Ltd]
  • General Injectables & Vaccines, Inc
    Phenylephrine Hydrochloride Injection, Solution [General Injectables & Vaccines, Inc]
  • Cardinal Health
    Phenylephrine Hydrochloride Injection, Solution [Cardinal Health]
  • Aaa Pharmaceutical, Inc.
    Phenylephrine Hydrochloride Tablet, Coated [Aaa Pharmaceutical, Inc.]
  • Cardinal Health
    Phenylephrine Hydrochloride Injection [Cardinal Health]
  • General Injectables & Vaccines, Inc
    Phenylephrine Hydrochloride Injection [General Injectables & Vaccines, Inc]
  • Cardinal Health
    Phenylephrine Hydrochloride Injection [Cardinal Health]
  • West-ward Pharmaceutical Corp.
    Phenylephrine Hydrochloride Injection [West-ward Pharmaceutical Corp.]

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