Pilocarpine Hydrochloride

Pilocarpine Hydrochloride

Pilocarpine Hydrochloride Recall

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Questions & Answers

Side Effects & Adverse Reactions

Cardiovascular Disease: Patients with significant cardiovascular disease may be unable to compensate for transient changes in hemodynamics or rhythm induced by pilocarpine. Pulmonary edema has been reported as a complication of pilocarpine toxicity from high ocular doses given for acute angle-closure glaucoma. Pilocarpine should be administered with caution in and under close medical supervision of patients with significant cardiovascular disease.

Ocular: Ocular formulations of pilocarpine have been reported to cause visual blurring which may result in decreased visual acuity, especially at night and in patients with central lens changes, and to cause impairment of depth perception. Caution should be advised while driving at night or performing hazardous activities in reduced lighting.

Pulmonary Disease: Pilocarpine has been reported to increase airway resistance, bronchial smooth muscle tone, and bronchial secretions. Pilocarpine hydrochloride should be administered with caution to and under close medical supervision in patients with controlled asthma, chronic bronchitis, or chronic obstructive pulmonary disease requiring pharmacotherapy.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Pilocarpine Hydrochloride Tablets are indicated for 1) the treatment of symptoms of dry mouth from salivary gland hypofunction caused by radiotherapy for cancer of the head and neck; and 2) the treatment of symptoms of dry mouth in patients with Sjogren's Syndrome.

History

There is currently no drug history available for this drug.

Other Information

Pilocarpine Hydrochloride Tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine hydrochloride is a hygroscopic, odorless, bitter tasting white crystal or powder which is soluble in water and alcohol and virtually insoluble in most non-polar solvents. Pilocarpine hydrochloride, with a chemical name of (3S-cis)-2(3H)-Furanone, 3-ethyldihydro-4-[(1 -methyl-1H-imidazol-5-yl) methyl] monohydrochloride, has a molecular weight of 244.72.

Pilocarpine hydrochloride structural formula

Each 5 mg Pilocarpine Hydrochloride Tablet for oral administration contains 5 mg of pilocarpine hydrochloride. Inactive ingredients in the tablet, the tablet's film coating, and polishing are: carnauba wax, hypromellose, microcrystalline cellulose, stearic acid, titanium dioxide and other ingredients.

Each 7.5 mg Pilocarpine Hydrochloride Tablet for oral administration contains 7.5 mg of pilocarpine hydrochloride. Inactive ingredients in the tablet, the tablet's film coating, and polishing are: carnauba wax, hypromellose, microcrystalline cellulose, stearic acid, titanium dioxide, FD&C blue # 2 aluminum lake, and other ingredients.

Pilocarpine Hydrochloride Manufacturers


  • American Health Packaging
    Pilocarpine Hydrochloride Tablet, Film Coated [American Health Packaging]
  • Marlex Pharmaceuticals Inc
    Pilocarpine Hydrochloride Tablet, Film Coated [Marlex Pharmaceuticals Inc]
  • Rebel Distributors Corp
    Pilocarpine Hydrochloride Tablet [Rebel Distributors Corp]
  • Physicians Total Care, Inc.
    Pilocarpine Hydrochloride Tablet, Film Coated [Physicians Total Care, Inc.]
  • Global Pharmaceuticals, Division Of Impax Laboratories, Inc.
    Pilocarpine Hydrochloride Tablet, Film Coated [Global Pharmaceuticals, Division Of Impax Laboratories, Inc.]
  • Corepharma, Llc
    Pilocarpine Hydrochloride Tablet, Film Coated [Corepharma, Llc]
  • Actavis Elizabeth Llc
    Pilocarpine Hydrochloride Tablet, Film Coated [Actavis Elizabeth Llc]
  • Roxane Laboratories, Inc
    Pilocarpine Hydrochloride Tablet [Roxane Laboratories, Inc]
  • Kaiser Foundation Hospitals
    Pilocarpine Hydrochloride Tablet, Film Coated [Kaiser Foundation Hospitals]
  • Lannett Company, Inc.
    Pilocarpine Hydrochloride Tablet, Film Coated [Lannett Company, Inc.]
  • American Health Packaging
    Pilocarpine Hydrochloride Tablet, Film Coated [American Health Packaging]

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