Pirsue
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Questions & Answers
Side Effects & Adverse Reactions
Repeated infusion during extended duration therapy regimens, even with adequate teat end preparation and sanitation, can result in elevated somatic cell counts and/or clinical mastitis, which can result in animal death. If acute clinical mastitis or other clinical signs of illness develop during extended duration therapy with PIRSUE, discontinue therapy immediately and contact your veterinarian.
Discard Empty Container; DO NOT REUSE
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- Milk taken from animals during treatment and for 36 hours after the last treatment must not be used for food regardless of treatment duration.
- Following infusion twice at a 24-hour interval, treated animals must not be slaughtered for 9 days.
- Following any extended duration of therapy (infusion longer than twice at a 24-hour interval, up to 8 consecutive days), animals must not be slaughtered for 21 days.
- Use of this product in a manner other than indicated under DOSAGE might result in violative residues.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
There is currently no usage information available for this product. We apologize for any inconvenience.
History
There is currently no drug history available for this drug.
Other Information
Pirlimycin hydrochloride is a lincosaminide antibiotic.
| Chemical Structure of Pirlimycin Hydrochloride |
 |
| Chemical Name of Pirlimycin Hydrochloride |
| Methyl(2S-Cis)-7-chloro-6,7,8-trideoxy-6[[(4-ethyl-2-piperidinyl)carbonyl]amino]-1-thio-L-threo-α-D-galacto-octo-pyranoside monohydrochloride hydrate. |
PIRSUE Sterile Solution is a clear solution.
| Each 10 mL PLASTET® Disposable Syringe contains: | |
| Pirlimycin free base equivalents | 50 mg |
| Aqueous vehicle | q.s. |
Sources
Pirsue Manufacturers
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Pharmacia And Upjohn Company
![Pirsue (Pirlimycin Hydrochloride) Injection, Solution [Pharmacia And Upjohn Company]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Pirsue | Pharmacia And Upjohn Company
Infuse one (1) syringe into each affected quarter. Use proper teat end preparation and sanitation and proper intramammary infusion technique (see ADMINISTRATION). Repeat treatment after 24 hours. Daily treatment may be repeated at 24-hour intervals for up to 8 consecutive days.
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Zoetis Inc
Pirsue | Zoetis Inc
Infuse one (1) syringe into each affected quarter. Use proper teat end preparation and sanitation and proper intramammary infusion technique (see ADMINISTRATION). Repeat treatment after 24 hours. Daily treatment may be repeated at 24-hour intervals for up to 8 consecutive days.
Teat End Preparation: Wash teats thoroughly with water containing a suitable dairy antiseptic. Dry the teats thoroughly. Milk out the udder completely. Using the alcohol pad provided, wipe the teat end of the affected quarters, using a separate pad for each teat. Allow sufficient time (at least 5 to 10 seconds) for the alcohol to dry. Use of protective gloves by persons applying treatment is recommended as part of aseptic infusion technique.
Important Considerations for Extended Therapy: For extended duration of therapy, infuse only quarters known to be infected with label pathogens. Do not concurrently infuse uninfected low SCC quarters of the same cow. Prepare the teats using the above instructions, and then infuse PIRSUE Sterile Solution using aseptic infusion technique and partial insertion (see diagram below).
Infusion: The Plastet disposable syringe is designed to provide the choice of either insertion of the full cannula as has traditionally been practiced, or insertion of no more than 1/8 inch of the cannula, as reported by Eberhart, R.J., et. al., 1987. Current Concepts of Bovine Mastitis, 3rd Edition, National Mastitis Council, Arlington, VA.
a. Full insertion: Remove the white end cap by pulling straight up as shown. Gently insert the full cannula into the teat canal.
b. Partial insertion: Remove the white end cap by pulling straight up as shown. Gently insert the exposed white tip into the teat canal.
Choose the desired insertion length (full or partial) and gently insert the tip into the teat canal. Carefully push the plunger to infuse the entire contents, and then massage the quarter to distribute the solution into the milk cistern. Following infusion, dip all quarters with an antiseptic teat dip. Cows with systemic clinical signs caused by mastitis should receive other appropriate therapy under the direction of a licensed veterinarian.
Reinfection: After treatment, reinfection may occur unless good herd management, sanitation, and mechanical safety measures are practiced. Affected cows should be watched carefully to detect recurrence and possible spread of infection to other animals.
![Pirsue (Pirlimycin Hydrochloride) Injection, Solution [Zoetis Inc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=e23fbeaf-39f8-4777-af2f-8f3a2cb015e2&name=pirsue-03.jpg)
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