Polocaine

Polocaine Manufacturers

• App Pharmaceuticals, Llc
  

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  Polocaine | App Pharmaceuticals, Llc

  

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  The dose of any local anesthetic administered varies with the anesthetic procedure, the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, the depth of anesthesia and degree of muscle relaxation required, the duration of anesthesia desired, individual tolerance and the physical condition of the patient.  The smallest dose and concentration required to produce the desired result should be administered.  Dosages of mepivacaine hydrochloride should be reduced for elderly and debilitated patients and patients with cardiac and/or liver disease.  The rapid injection of a large volume of local anesthetic solution should be avoided and fractional doses should be used when feasible.

              For specific techniques and procedures, refer to standard textbooks.

              The recommended single adult dose (or the total of a series of doses given in one procedure) of mepivacaine hydrochloride for unsedated, healthy, normal-sized individuals should not usually exceed 400 mg.  The recommended dosage is based on requirements for the average adult and should be reduced for elderly or debilitated patients.

              While maximum doses of 7 mg/kg (550 mg) have been administered without adverse effect, these are not recommended, except in exceptional circumstances and under no circumstances should the administration be repeated at intervals of less than 1½ hours.  The total dose for any 24-hour period should not exceed 1,000 mg because of a slow accumulation of the anesthetic or its derivatives or slower than normal metabolic degradation or detoxification with repeat administration (see CLINICAL PHARMACOLOGY and PRECAUTIONS).

              Pediatric patients tolerate the local anesthetic as well as adults.  However, the pediatric dose should be carefully measured as a percentage of the total adult dose based on weight, and should not exceed 5 mg/kg to 6 mg/kg (2.5 mg/lb to 3 mg/lb) in pediatric patients, especially those weighing less than 30 lbs.  In pediatric patients under 3 years of age or weighing less than 30 lbs concentrations less than 2% (eg, 0.5% to 1.5%) should be employed.

              Unused portions of solutions not containing preservatives, ie, those supplied in single-dose vials, should be discarded following initial use.

              This product should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.  Solutions which are discolored or which contain particulate matter should not be administered.

  Recommended Concentrations and Doses of Mepivacaine Hydrochloride

  
  

  Procedure

   

  Concentration

   

  
  

  mL

  Total Dose

   

  
  

  mg

     Comments

   

  Cervical,

   

  1%

   

  5-40

   

  
  

  50-400

   

     Pudendal block:

   

  brachial,

  
  
  
  
  

     one half of total

  
  
  
  
  
  
  

  intercostal,

  
  
  
  
  

     dose injected

  
  
  
  
  
  
  

  pudendal

  2%

  5-20

  
  

  100-400

     each side.

  
  
  
  
  
  
  

  nerve block

   

  
  
  
  
  
  

  Transvaginal

   

  1%

   

  up to 30

   

  
  

  up to 300

   

     One half of total

   

  block

  
  

  (both sides)

  
  

  (both sides)

     dose injected

  
  
  
  
  
  
  

  (paracervical

  
  
  
  
  

     each side.  See

  
  
  
  
  
  
  

  plus pudendal)

   

  
  
  
  
  

     PRECAUTIONS.

   

  Paracervical

   

  1%

   

  up to 20

   

  
  

  up to 200

   

     One half of total

   

  block

  
  

  (both sides)

  
  

  (both sides)

     dose injected each

  
  
  
  
  
  
  
  
  
  
  
  

     side.  This is maxi-

  
  
  
  
  
  
  
  
  
  
  
  

     mum recommended

  
  
  
  
  
  
  
  
  
  
  
  

     dose per 90-minute

  
  
  
  
  
  
  
  
  
  
  
  

     period in obstetrical

  
  
  
  
  
  
  
  
  
  
  
  

     and non-obstetrical

  
  
  
  
  
  
  
  
  
  
  
  

     patients.  Inject slowly,

  
  
  
  
  
  
  
  
  
  
  
  

     5 minutes between

  
  
  
  
  
  
  
  
  
  
  
  

     sides. See

  
  
  
  
  
  
  
  
  
  
  
  

     PRECAUTIONS.

   

  Caudal and

   

  1%

   

  15-30

   

           
  

  150-300

   

     *Use only single-dose

   

  Epidural block

  1.5%

  10-25

  
  

  150-375

     vials which do not

  
  
  
  
  
  
  
  

  2%

   

  10-20

   

  
  

  200-400

   

     contain a preservative.

   

  Infiltration

   

  1%

   

  up to 40

   

  
  

  up to 400

   

     An equivalent amount

   

  
  
  
  
  
  

     of a 0.5% solution

  
  
  
  
  
  
  
  
  
  
  
  

     (prepared by diluting

  
  
  
  
  
  
  
  
  
  
  
  

     the 1% solution with

  
  
  
  
  
  
  
  
  
  
  
  

     Sodium Chloride

  
  
  
  
  
  
  
  
  
  
  
  

     Injection, USP) may

  
  
  
  
  
  
  
  
  
  
  
  

     be used for large

  
  
  
  
  
  
  
  
  
  
  
  

     areas.

   

  Therapeutic

   

  1%

   

  1-5

   

  
  

  10-50

   

  
  

  block (pain

  2%

  1-5

  
  

  20-100

  
  
  
  
  
  
  
  

  management)

  
  
  
  
  
  
  
  
  
  
  
  

  Unused portions of solutions not containing preservatives should be discarded.

  * Dosage forms listed as POLOCAINE-MPF (Mepivacaine HCl Injection, USP) are single-dose solutions which do not contain a preservative.

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• Dentsply Pharmaceutical
  

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  Polocaine | Dentsply Pharmaceutical

  

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  As with all local anesthetics, the dose varies and depends upon the area to be anesthetized, the vascularity of the tissues, individual tolerance and the technique of anesthesia. The lowest dose needed to provide effective anesthesia should be administered. For specific techniques and procedures refer to standard dental manuals and textbooks.

  For infiltration and block injections in the upper or lower jaw, the average dose of 1 cartridge will usually suffice.

  Each cartridge contains 1.7 mL (34 mg of 2% or 51 mg of 3%).

  5.3 cartridges (180 mg of the 2% solution or 270 mg of the 3% solution) are usually adequate to effect anesthesia of the entire oral cavity. Whenever a larger dose seems to be necessary for an extensive procedure, the maximum dose should be calculated according to the patient's weight. A dose of up to 3 mg per pound of body weight may be administered. At any single dental sitting the total dose for all injected sites should not exceed 400 mg in adults.

  The maximum pediatric dose should be carefully calculated.

  Maximum dose for pediatric population =

  Child's Weight (lbs.) × Maximum Recommended Dose 150 for Adults (400 mg)

  The following table, approximating these calculations, may also be used as a guide. This table is based upon a recommended maximum for larger pediatric population of 5.3 cartridges (the maximum recommended adult dose) during any single dental sitting, regardless of the pediatric patient's weight or (for 2% mepivacaine) calculated maximum amount of drug:

  Maximum Allowable Dosage* 3% Mepivacaine
  Plain 2% Mepivacaine
  1:20,000 Levonordefrin 3 mg/lb
  (270 mg max.) 3 mg/lb
  (180 mg max.) Weight
  (lb.) mg Number of Cartridges mg Number of Cartridges * Adapted from Malamed, Stanley F: Handbook of medical emergencies in the dental office, ed. 2, St. Louis, 1982. The C.V. Mosby Co. 20 60 1.2 60 1.8 30 90 1.8 90 2.6 40 120 2.3 120 3.5 50 150 2.9 150 4.4 60 180 3.5 180 5.3 80 240 4.7 180 5.3 100 270 5.3 180 5.3 120 270 5.3 180 5.3

  When using Polocaine® for infiltration or regional block anesthesia, injection should always be made slowly and with frequent aspiration.

  Any unused portion of a cartridge should be discarded.

  Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

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