
The administration of intravenous solutions can cause fluid and/or solute overload resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema. The risk of dilutional states is inversely proportional to the electrolyte concentration. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentration.
Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there is sodium retention with edema.
Infusion of isotonic (0.9%) sodium chloride during or immediately after surgery may result in excessive sodium retention. Use the patient’s circulatory system status as a guide.
In patients with diminished renal function, administration of solutions containing sodium or potassium ions may result in sodium or potassium retention. Solutions containing potassium ions should be used with great care, if at all, in patients with hyperkalemia, severe renal failure, and in conditions in which potassium retention is present.
There is currently no manufacturer warning information available for this drug.
Potassium Chloride in 0.9% Sodium Chloride Injections are indicated for use in adults and pediatric patients as sources of electrolytes and water for hydration.
Each 100 mL of 0.15% Potassium Chloride in 0.9% Sodium Chloride Injection (20 mEq K+/liter) contains: Sodium Chloride USP 0.9 g
Potassium Chloride USP 0.15 g; Water for Injection USP qs
pH may be adjusted with Hydrochloric Acid NF
pH: 5.6 (3.5–6.5) Calculated Osmolarity: 350 mOsmol/liter
Concentration of Electrolytes (mEq/liter):
Sodium 154 Potassium 20 Chloride 174
Each 100 mL of 0.30% Potassium Chloride in 0.9% Sodium Chloride Injection (40 mEq K+/liter) contains: Sodium Chloride USP 0.9 g
Potassium Chloride USP 0.3 g; Water for Injection USP qs
pH may be adjusted with Hydrochloric Acid NF
pH: 5.6 (3.5–6.5) Calculated Osmolarity: 390 mOsmol/liter
Concentration of Electrolytes (mEq/liter):
Sodium 154 Potassium 40 Chloride 194
Potassium Chloride in 0.9% Sodium Chloride Injections are sterile, nonpyrogenic, hypertonic and contain no bacteriostatic or antimicrobial agents. These products are intended for intravenous administration.
The formulas of the active ingredients are:
| Ingredients | Molecular Formula |
Molecular Weight |
|---|---|---|
| Sodium Chloride USP | NaCl | 58.44 |
| Potassium Chloride USP | KCl | 74.55 |
The EXCEL® Container is Latex-free, PVC-free, and DEHP-free.
The plastic container is made from a multilayered film specifically developed for parenteral drugs. It contains no plasticizers and exhibits virtually no leachables. The solution contact layer is a rubberized copolymer of ethylene and propylene. The container is nontoxic and biologically inert. The container-solution unit is a closed system and is not dependent upon entry of external air during administration. The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary.
Addition of medication should be accomplished using complete aseptic technique. The closure system has two ports; the one for the administration set has a tamper evident plastic protector and the other is a medication addition site. Refer to the Directions for Use of the container.