Potassium Chloride In Sodium Chloride
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Questions & Answers
Side Effects & Adverse Reactions
The administration of intravenous solutions can cause fluid and/or solute overload resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema. The risk of dilutional states is inversely proportional to the electrolyte concentration. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentration.
Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there is sodium retention with edema.
Infusion of isotonic (0.9%) sodium chloride during or immediately after surgery may result in excessive sodium retention. Use the patient's circulatory system status as a guide.
In patients with diminished renal function, administration of solutions containing sodium or potassium ions may result in sodium or potassium retention. Solutions containing potassium ions should be used with great care, if at all, in patients with hyperkalemia, severe renal failure, and in conditions in which potassium retention is present.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Potassium Chloride in 0.9% Sodium Chloride Injections are indicated for use in adults and pediatric patients as sources of electrolytes and water for hydration.
History
There is currently no drug history available for this drug.
Other Information
Each 100 mL of 0.15% Potassium Chloride in 0.9% Sodium Chloride Injection (20 mEq K+/liter) contains: Sodium Chloride USP 0.9 g
Potassium Chloride USP 0.15 g; Water for Injection USP qs
pH may be adjusted with Hydrochloric Acid NF
pH: 5.6 (3.5–6.5) Calculated Osmolarity: 350 mOsmol/liter
Concentration of Electrolytes (mEq/liter):
Sodium 154 Potassium 20 Chloride 174
Each 100 mL of 0.30% Potassium Chloride in 0.9% Sodium Chloride Injection (40 mEq K+/liter) contains: Sodium Chloride USP 0.9 g
Potassium Chloride USP 0.3 g; Water for Injection USP qs
pH may be adjusted with Hydrochloric Acid NF
pH: 5.6 (3.5–6.5) Calculated Osmolarity: 390 mOsmol/liter
Concentration of Electrolytes (mEq/liter):
Sodium 154 Potassium 40 Chloride 194
Potassium Chloride in 0.9% Sodium Chloride Injections are sterile, nonpyrogenic, hypertonic and contain no bacteriostatic or antimicrobial agents. These products are intended for intravenous administration.
The formulas of the active ingredients are:
| Ingredients | Molecular Formula |
Molecular Weight |
|---|---|---|
| Sodium Chloride USP | NaCl | 58.44 |
| Potassium Chloride USP | KCl | 74.55 |
The EXCEL® Container is Latex-free, PVC-free, and DEHP-free.
The plastic container is made from a multilayered film specifically developed for parenteral drugs. It contains no plasticizers and exhibits virtually no leachables. The solution contact layer is a rubberized copolymer of ethylene and propylene. The container is nontoxic and biologically inert. The container-solution unit is a closed system and is not dependent upon entry of external air during administration. The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary.
Addition of medication should be accomplished using complete aseptic technique. The closure system has two ports; the one for the administration set has a tamper evident plastic protector and the other is a medication addition site. Refer to the Directions for Use of the container.
Sources
Potassium Chloride In Sodium Chloride Manufacturers
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B. Braun Medical Inc.
![Potassium Chloride In Sodium Chloride (Sodium Chloride And Potassium Chloride) Solution [B. Braun Medical Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Potassium Chloride In Sodium Chloride | B. Braun Medical Inc.
These solutions are for intravenous use only.
Dosage is to be directed by a physician and is dependent upon age, weight, clinical condition of the patient and laboratory determinations. Frequent laboratory determinations and clinical evaluation are essential to monitor changes in blood glucose and electrolyte concentrations, and fluid and electrolyte balance during prolonged parenteral therapy.
When a hypertonic solution is to be administered peripherally, it should be slowly infused through a small bore needle, placed well within the lumen of a large vein to minimize venous irritation. Carefully avoid infiltration.
In the average adult, daily requirements of sodium and chloride are met by the infusion of one liter of 0.9% sodium chloride (154 mEq each of sodium and chloride).
Usually up to 40 mEq of potassium per liter daily is sufficient to replace normal loss in adults. Infusion rates should not exceed 10 mEq per hour or 120 mEq per day. A liter of fluid containing 40 mEq of potassium should be administered over an 8-hour period.
Fluid administration should be based on calculated maintenance or replacement fluid requirements for each patient.
Pediatric Dosage and AdministrationThere is no specific pediatric dose. The dose is dependent on weight, clinical condition and laboratory results.
See WARNINGS and PRECAUTIONS.
Some additives may be incompatible. Consult with pharmacist. When introducing additives, use aseptic techniques. Mix thoroughly. Do not store.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
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Hospira, Inc.
Potassium Chloride In Sodium Chloride | Hospira, Inc.
These solutions should be administered only by intravenous infusion and as directed by the physician. The dose and rate of injection are dependent upon the age, weight and clinical condition of the patient. If the serum potassium level is greater than 2.5 mEq/liter, potassium should be given at a rate not to exceed 10 mEq/hour in a concentration less than 30 mEq/liter. Somewhat faster rates and greater concentrations (usually up to 40 mEq/liter) of potassium may be indicated in patients with more severe potassium deficiency. The total 24-hour dose should not generally exceed 200 mEq of potassium.
Drug InteractionsAdditives may be incompatible. Consult with pharmacist, if available. When introducing additives, use aseptic technique, mix thoroughly and do not store.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (See PRECAUTIONS.)
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Baxter Healthcare Corporation
Potassium Chloride In Sodium Chloride | Baxter Healthcare Corporation
As directed by a physician. Dosage is dependent upon the age, weight and clinical condition of the patient as well as laboratory determinations.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Use of final filter is recommended during administration of all parenteral solutions, where possible.
All injections in VIAFLEX Plus plastic containers are intended for intravenous administration using sterile equipment.
Additives may be incompatible. Complete information is not available. Those additives known to be incompatible should not be used. Consult with pharmacist, if available. If, in the informed judgment of the physician, it is deemed advisable to introduce additives, use aseptic technique. Mix thoroughly when additives have been introduced. Do not store solutions containing additives.
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Hospira, Inc.
Potassium Chloride In Sodium Chloride | Hospira, Inc.
There is currently no dosage information available for this product. We apologize for any inconvenience.
![Potassium Chloride In Sodium Chloride (Sodium Chloride And Potassium Chloride) Injection, Solution [Hospira, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=78e70270-3864-423e-f89b-656822fa35df&name=intravenous-solutions-with-potassium-chloride1-figure-1-jIM-0477.jpg)
![Potassium Chloride In Sodium Chloride (Potassium Chloride And Sodium Chloride) Injection, Solution [Baxter Healthcare Corporation]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=becc7410-0a25-49f5-b0c3-240078479dc8&name=PotassiumChlorideinSodiumChlorideRepresentativeCartonLabelNDC0338-0691-04.jpg)
![Potassium Chloride In Sodium Chloride (Sodium Chloride And Potassium Chloride) Injection, Solution [Hospira, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=3a3343e4-b480-4454-e28b-9f3cba932948&name=potassium-chloride-in-sodium-chloride-injection-usp1-figure-1-jIM-1673.jpg)
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