Prascend

Prascend Manufacturers

• Boehringer Ingelheim Vetmedica, Inc.
  

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  Prascend | Boehringer Ingelheim Vetmedica, Inc.

  

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  Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets.

  The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment (see Table 1).

  Table 1 Dosing Table Dosage Dosage Body weight 2 mcg/kg 4 mcg/kg

  136 - 340 kg

  (300 - 749 lb)

  0.5 tablet 1 tablet

  341 - 567 kg

  750 - 1,249 lb)

  1 tablet 2 tablets

  568 - 795 kg

  (1,250 - 1,749 lb)

  1.5 tablets 3 tablets

  796 - 1,022 kg

  (1,750 - 2,249 lb)

  2 tablets 4 tablets

  Dosing should be titrated according to individual response to therapy to achieve the lowest effective dose. Dose titration is based on improvement in clinical signs associated with Pituitary Pars Intermedia Dysfunction (PPID) and/or improvement or normalization of endocrine tests (for example, dexamethasone suppression test or endogenous ACTH test). If signs of dose intolerance develop, the dose should be decreased by half for 3 to 5 days and then titrated back up in 2 mcg/kg increments every 2 weeks until the desired effect is achieved.

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