Prednisolone Sodium Phosphate Solution/ Drops
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Questions & Answers
Side Effects & Adverse Reactions
NOT FOR INJECTION INTO EYE - FOR TOPICAL USE ONLY
Employment of steroid medication in the treatment of herpes simplex keratitis involving the stroma requires great caution; frequent slit-lamp microscopy is mandatory.
Prolonged use may result in elevated intraocular pressure and/or glaucoma, damage to the optic nerve, defects in visual acuity and fields of vision, posterior subcapsular cataract formation, or may aid in the establishment of secondary ocular infections from pathogens liberated from ocular tissues. In those diseases causing thinning of the cornea or sclera, perforation has been known to occur with the use of topical steroids. Acute purulent untreated infection of the eye may be masked or activity enhanced by presence of steroid medication. Viral, bacterial, and fungal infections of the cornea may be exacerbated by the application of steroids.
This drug is not effective in mustard gas keratitis and Sjögren’s keratoconjuncitivitis.
If irritation persists or develops, the patient should be advised to discontinue use and consult prescribing physician.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Prednisolone Sodium Phosphate Ophthalmic Solution 1% or 1/8% is for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe, such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation, corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies.
Prednisolone Sodium Phosphate Ophthalmic Solution, 1%, is recommended for moderate to severe inflammations, particularly when unusually rapid control is desired. In stubborn cases of anterior segment eye disease, systemic adrenocortical hormone therapy may be required. When deeper ocular structures are involved, systemic therapy is necessary.
History
There is currently no drug history available for this drug.
Other Information
Prednisolone Sodium Phosphate Ophthalmic Solution, 1%, is a sterile solution for ophthalmic administration having the following composition:
Each mL Contains:
ACTIVE: Prednisolone Sodium Phosphate 10 mg (1%) [equivalent to 9.1 mg/mL prednisolone phosphate] in a buffered isotonic solution containing INACTIVES: Hypromellose, Monobasic and Dibasic Sodium Phosphate, Sodium Chloride, Edetate Disodium and Purified Water. Sodium Hydroxide and/or Hydrochloric Acid may be added to adjust the pH (6.2 - 8.2).
PRESERVATIVE ADDED: Benzalkonium Chloride 0.01%.
The chemical name for prednisolone sodium phosphate is Pregna-1, 4-diene - 3, 20-dione, 11, 17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11 β) -, which has the following structural formula:
Molecular formula: C21H27Na2O8P
Molecular Weight: 484.39
Sources
Prednisolone Sodium Phosphate Solution/ Drops Manufacturers
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Mwi/vetone
![Prednisolone Sodium Phosphate Solution/ Drops [Mwi/vetone]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Prednisolone Sodium Phosphate Solution/ Drops | Mwi/vetone
Depending on the severity of inflammation, instill one or two drops of solution into the conjunctival sac up to every hour during the day and every two hours during the night as necessary as initial therapy.
When a favorable response is observed, reduce dosage to one drop every four hours.
Later, further reduction in dosage to one drop three to four times daily may suffice to control symptoms.
The duration of treatment will vary with the type of lesion and may extend from a few days to several weeks, according to therapeutic response. Relapses, more common in chronic active lesions than in self-limited conditions, usually respond to retreatment.
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Butler Animal Health Supply
Prednisolone Sodium Phosphate Solution/ Drops | Butler Animal Health Supply
Depending on the severity of inflammation, instill one or two drops of solution into the conjunctival sac up to every hour during the day and every two hours during the night as necessary as initial therapy.
When a favorable response is observed, reduce dosage to one drop every four hours.
Later, further reduction in dosage to one drop three to four times daily may suffice to control symptoms.
The duration of treatment will vary with the type of lesion and may extend from a few days to several weeks, according to therapeutic response. Relapses, more common in chronic active lesions than in self-limited conditions, usually respond to retreatment.
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Bausch & Lomb Incorporated
Prednisolone Sodium Phosphate Solution/ Drops | Bausch & Lomb Incorporated
Depending on the severity of inflammation, instill one or two drops of solution into the conjunctival sac up to every hour during the day and every two hours during the night as necessary as initial therapy.
When a favorable response is observed, reduce dosage to one drop every four hours.
Later, further reduction in dosage to one drop three to four times daily may suffice to control symptoms.
The duration of treatment will vary with the type of lesion and may extend from a few days to several weeks, according to therapeutic response. Relapses, more common in chronic active lesions than in self-limited conditions, usually respond to retreatment.
![Prednisolone Sodium Phosphate Solution/ Drops [Butler Animal Health Supply]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=21092699-6ba7-42d2-b148-66a669084bc6&name=21092699-6ba7-42d2-b148-66a669084bc6-02.jpg)
![Prednisolone Sodium Phosphate Solution/ Drops [Bausch & Lomb Incorporated]](https://www.recallguide.org/wp-content/themes/bootstrap/assets/img/drug-image-placeholder.jpg)
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