Probenecid Recall

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Questions & Answers

Side Effects & Adverse Reactions

Exacerbation of gout following therapy with probenecid may occur; in such cases colchicine or other appropriate therapy is advisable.

Probenecid increases plasma concentrations of methotrexate in both animals and humans. In animal studies, increased methotrexate toxicity has been reported. If probenecid is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored.

In patients on probenecid the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid. The biphasic action of salicylates in the renal tubules accounts for the so-called "paradoxical effect" of uricosuric agents. In patients on probenecid who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred.

Rarely, severe allergic reactions and anaphylaxis have been reported with the use of probenecid. Most of these have been reported to occur within several hours after readministration following prior usage of the drug.

The appearance of hypersensitivity reactions requires cessation of therapy with probenecid.

Use in Pregnancy:

Probenecid crosses the placental barrier and appears in cord blood. The use of any drug in women of childbearing potential requires that the anticipated benefit be weighed against the possible hazards.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Probenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis.

As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given.


There is currently no drug history available for this drug.

Other Information

Probenecid is a uricosuric and renal tubular transport blocking agent.

The chemical name for probenecid is 4-[(dipropylamino) sulfonyl] benzoic acid. It has the following structural formula:

probenecid structural formula

Probenecid, USP is a white or nearly white, fine, crystalline powder. Probenecid is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids.

Each tablet for oral administration contains 500 mg of probenecid and the following inactive ingredients: microcrystalline cellulose, sodium lauryl sulfate, sodium starch glycolate, starch (corn), povidone, colloidal silicon dioxide, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, D&C Yellow #10 Aluminum Lake, FD&C Yellow #6 Aluminum Lake, and FD&C Blue #2 Aluminum Lake.

Probenecid Manufacturers

  • American Health Packaging
    Probenecid Tablet, Film Coated [American Health Packaging]
  • Lannett Company, Inc.
    Probenecid Tablet, Film Coated [Lannett Company, Inc.]
  • Watson Laboratories, Inc.
    Probenecid Tablet, Film Coated [Watson Laboratories, Inc.]
  • Hhs/program Support Center/supply Service Center
    Probenecid Tablet, Film Coated [Hhs/program Support Center/supply Service Center]
  • Physicians Total Care, Inc.
    Probenecid Tablet, Film Coated [Physicians Total Care, Inc.]
  • Marlex Pharmaceuticals Inc
    Probenecid Tablet, Film Coated [Marlex Pharmaceuticals Inc]
  • Aphena Pharma Solutions – Tennessee, Llc
    Probenecid Tablet, Film Coated [Aphena Pharma Solutions – Tennessee, Llc]
  • Mylan Pharmaceuticals Inc.
    Probenecid Tablet, Film Coated [Mylan Pharmaceuticals Inc.]
  • Carilion Materials Management
    Probenecid Tablet, Film Coated [Carilion Materials Management]

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