Propoflo 28

Propoflo 28

Propoflo 28 Recall

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Questions & Answers

Side Effects & Adverse Reactions

Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. In cases of respiratory depression, stop drug administration, establish a patent airway, and initiate assisted or controlled ventilation with pure oxygen. Cardiovascular depression should be treated with plasma expanders, pressor agents, antiarrhythmic agents or other techniques as appropriate for the observed abnormality.

 When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


PropoFlo™ 28 is an intravenous anesthetic injection for use in dogs as follows:

For induction of anesthesia.

For maintenance of general anesthesia by intermittent bolus injections for short procedures.

For induction of general anesthesia where maintenance is provided by inhalant anesthetics.


There is currently no drug history available for this drug.

Other Information

PropoFlo™ 28 is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol in a multidose vial for intravenous administration. Each mL contains 10 mg propofol. Propofol is chemically described as 2, 6-diisopropylphenol and has a molecular weight of 178.27. Propofol is very slightly soluble in water and is therefore formulated as a white, oil-in-water emulsion. In addition to the active component, propofol, the formulation also contains soybean oil (100 mg/mL), glycerol (22.5 mg/mL), benzyl alcohol (20 mg/mL), oleic acid (0.6 mg/mL), and egg lecithin (12 mg/mL), with sodium hydroxide to adjust the pH. The PropoFlo™ 28 emulsion is isotonic and has a pH of 6.0-8.5. PropoFlo™ 28 does not meet the propofol injectable emulsion USP specification for free fatty acids.

Propoflo 28 Manufacturers

  • Abbott Laboratories
    Propoflo 28 (Propofol) Injection, Emulsion [Abbott Laboratories]

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