Pyrazinamide
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Questions & Answers
Side Effects & Adverse Reactions
Patients started on pyrazinamide should have baseline serum uric acid and liver function determinations. Those patients with preexisting liver disease or those at increased risk for drug related hepatitis (e.g., alcohol abusers) should be followed closely.
Pyrazinamide should be discontinued and not be resumed if signs of hepatocellular damage or hyperuricemia accompanied by an acute gouty arthritis appear.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Pyrazinamide is indicated for the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents. (The current recommendation of the CDC for drug-susceptible disease is to use a six-month regimen for initial treatment of active tuberculosis, consisting of isoniazid, rifampin and pyrazinamide given for 2 months, followed by isoniazid and rifampin for 4 months.* 4)
(Patients with drug-resistant disease should be treated with regimens individualized to their situation. Pyrazinamide frequently will be an important component of such therapy.)
(In patients with concomitant HIV infection, the physician should be aware of current recommendations of CDC. It is possible these patients may require a longer course of treatment.)
It is also indicated after treatment failure with other primary drugs in any form of active tuberculosis.
Pyrazinamide should only be used in conjunction with other effective antituberculous agents.
*See recommendations of Center for Disease Control (CDC) and American Thoracic Society for complete regimen and dosage recommendations. 4
History
There is currently no drug history available for this drug.
Other Information
Pyrazinamide, the pyrazine analogue of nicotinamide, is an antituberculous agent. It is a white crystalline powder, stable at room temperature, and sparingly soluble in water. Pyrazinamide has the following structural formula:
C5H5N3O M.W. 123.11
Each Pyrazinamide tablet for oral administration contains 500 mg of pyrazinamide and the following inactive ingredients: Corn Starch, Magnesium Stearate, Pregelatinized Starch and Stearic Acid.
Sources
Pyrazinamide Manufacturers
- Remedyrepack Inc.
![Pyrazinamide Tablet [Remedyrepack Inc. ]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Pyrazinamide | Remedyrepack Inc.
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation. Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 to 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 70 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluating the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
The table is taken from the CDC-American Thoracic Society joint recommendations:4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and AdultsDaily Dose*
Maximal Daily
Dose in
Children
and Adults
Twice Weekly Dose
Drug
Children
Adults
Children
Adults
Isoniazid
10 to 20 mg/kg
PO or IM
5 mg/kg
PO or IM
300 mg
20 to 40 mg/kg
Max. 900 mg
15 mg/kg
Max. 900 mg
Rifampin
10 to 20 mg/kg
PO
10 mg/kg
PO
600 mg
10 to 20 mg/kg
Max. 600 mg
10 mg/kg
Max. 600 mg
Pyrazinamide
15 to 30 mg/kg
PO
15 to 30 mg/kg
PO
2 g
50 to 70 mg/kg
50 to 70 mg/kg
Streptomycin
20 to 40 mg/kg
IM
15 mg/kg**
IM
1 g**
25 to 30 mg/kg
IM
25 to 30 mg/kg
IM
Ethambutol
15 to 25 mg/kg
PO
15 to 25 mg/kg
PO
2.5 g
50 mg/kg
50 mg/kg
Definition of abbreviations: PO = perorally; IM = intramuscularly.
* Doses based on weight should be adjusted as weight changes.
**In persons older than 60 yrs of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg.
- Mikart, Inc.
Pyrazinamide | Mikart, Inc.
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation.
Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 or 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 75 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluation the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
This table is taken from the CDC-American Thoracic Society joint recommendations.4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and Adults Definition of abbreviations: PO = perorally; IM = intramuscularly. * Doses based on weight should be adjusted as weight changes. ** In persons older than 60 yr of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg..Daily Dose*
Maximal Daily Dose in Children and Adults
Twice Weekly Dose
Drug
Children
Adults
Children
Adults
Isoniazid
10 to 20 mg/kg
PO or IM
5 mg/kg
PO or IM
300 mg
20 to 40 mg/kg
Max. 900 mg
15 mg/kg
Max. 900 mg
Rifampin
10 to 20 mg/kg
PO
10 mg/kg
PO
600 mg
10 to 20 mg/kg
Max. 600 mg
10 mg/kg
Max. 600 mg
Pyrazinamide
15 to 30 mg/kg
PO
15 to 30 mg/kg
PO
2 g
50 to 70 mg/kg
50 to 70 mg/kg
Streptomycin
20 to 40 mg/kg
IM
15 mg/kg**
IM
1 g**
25 to 30 mg/kg
IM
25 to 30 mg/kg
IM
Ethambutol
15 to 25 mg/kg
PO
15 to 25 mg/kg
PO
2.5 g
50 mg/kg
50 mg/kg
- Remedyrepack Inc.
Pyrazinamide | Remedyrepack Inc.
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation.
Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 or 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 75 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluation the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
This table is taken from the CDC-American Thoracic Society joint recommendations.4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and Adults
*Doses based on weight should be adjusted as weight changes. In persons older than 60 yr of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg.Daily Dose *DrugChildrenAdultsIsoniazid10 to 20 mg/kg PO or IM5 mg/kg PO or IMRifampin10 to 20 mg/kg PO10 mg/kg POPyrazinamide15 to 30 mg/kg PO15 to 30 mg/kg POStreptomycin20 to 40 mg/kg IM15 mg/kg IMEthambutol15 to 25 mg/kg PO15 to 25 mg/kg PO
*In persons older than 60 yr of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg.Maximal Daily Dose in Children and AdultsDrugIsoniazid300 mgRifampin600 mgPyrazinamide2 gStreptomycin1 g *Ethambutol2.5 g
Twice Weekly DoseDrugChildrenAdultsIsoniazid20 to 40 mg/kg Max. 900 mg15 mg/kg Max. 900 mgRifampin10 to 20 mg/kg Max. 600 mg10 mg/kg Max. 600 mgPyrazinamide50 to 70 mg/kg50 to 70 mg/kgStreptomycin25 to 30 mg/kg IM25 to 30 mg/kg IMEthambutol50 mg/kg50 mg/kg
- Versapharm Incorporated
Pyrazinamide | Versapharm Incorporated
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation.
Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 or 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 75 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluation the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
This table is taken from the CDC-American Thoracic Society joint recommendations.4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and Adults * Doses based on weight should be adjusted as weight changes. † In persons older than 60 yr of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg. Daily Dose* Drug Children Adults Isoniazid10 to 20 mg/kg
PO or IM5 mg/kg
PO or IM Rifampin10 to 20 mg/kg
PO10 mg/kg
PO Pyrazinamide15 to 30 mg/kg
PO15 to 30 mg/kg
PO Streptomycin20 to 40 mg/kg
IM15 mg/kg†
IM Ethambutol15 to 25 mg/kg
PO15 to 25 mg/kg
PO * In persons older than 60 yr of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg. Maximal Daily Dose in Children and Adults Drug Isoniazid 300 mg Rifampin 600 mg Pyrazinamide 2 g Streptomycin 1 g* Ethambutol 2.5 g Twice Weekly Dose Drug Children Adults Isoniazid20 to 40 mg/kg
Max. 900 mg15 mg/kg
Max. 900 mg Rifampin10 to 20 mg/kg
Max. 600 mg10 mg/kg
Max. 600 mg Pyrazinamide 50 to 70 mg/kg 50 to 70 mg/kg Streptomycin25 to 30 mg/kg
IM25 to 30 mg/kg
IM Ethambutol 50 mg/kg 50 mg/kgDefinition of abbreviations: PO = per-orally; IM = intramuscularly.
- Remedyrepack Inc.
Pyrazinamide | Remedyrepack Inc.
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation.
Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 or 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 75 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluation the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
This table is taken from the CDC-American Thoracic Society joint recommendations.4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and Adults Daily Dose* Drug Children Adults Isoniazid10 to 20 mg/kg
PO or IM5 mg/kg
PO or IM Rifampin10 to 20 mg/kg
PO10 mg/kg
PO Pyrazinamide15 to 30 mg/kg
PO15 to 30 mg/kg
PO Streptomycin20 to 40 mg/kg
IM15 mg/kg†
IM Ethambutol15 to 25 mg/kg
PO15 to 25 mg/kg
PO
Maximal Daily Dose in Children and Adults Drug Isoniazid 300 mg Rifampin 600 mg Pyrazinamide 2 g Streptomycin 1 g* Ethambutol 2.5 g
Twice Weekly Dose Drug Children Adults Isoniazid20 to 40 mg/kg
Max. 900 mg15 mg/kg
Max. 900 mg Rifampin10 to 20 mg/kg
Max. 600 mg10 mg/kg
Max. 600 mg Pyrazinamide 50 to 70 mg/kg 50 to 70 mg/kg Streptomycin25 to 30 mg/kg
IM25 to 30 mg/kg
IM Ethambutol 50 mg/kg 50 mg/kgDefinition of abbreviations: PO = per-orally; IM = intramuscularly.
1 Doses based on weight should be adjusted as weight changes. 2 In persons older than 60 yr of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg. 3 In persons older than 60 yr of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg. - Remedyrepack Inc.
Pyrazinamide | Remedyrepack Inc.
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation. Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 to 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 70 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluating the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
The table is taken from the CDC-American Thoracic Society joint recommendations:4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and AdultsDaily Dose*
Maximal Daily
Dose in
Children
and Adults
Twice Weekly Dose
Drug
Children
Adults
Children
Adults
Isoniazid
10 to 20 mg/kg
PO or IM
5 mg/kg
PO or IM
300 mg
20 to 40 mg/kg
Max. 900 mg
15 mg/kg
Max. 900 mg
Rifampin
10 to 20 mg/kg
PO
10 mg/kg
PO
600 mg
10 to 20 mg/kg
Max. 600 mg
10 mg/kg
Max. 600 mg
Pyrazinamide
15 to 30 mg/kg
PO
15 to 30 mg/kg
PO
2 g
50 to 70 mg/kg
50 to 70 mg/kg
Streptomycin
20 to 40 mg/kg
IM
15 mg/kg**
IM
1 g**
25 to 30 mg/kg
IM
25 to 30 mg/kg
IM
Ethambutol
15 to 25 mg/kg
PO
15 to 25 mg/kg
PO
2.5 g
50 mg/kg
50 mg/kg
Definition of abbreviations: PO = perorally; IM = intramuscularly.
* Doses based on weight should be adjusted as weight changes.
**In persons older than 60 yrs of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg.
- Dava Pharmaceuticals, Inc.
Pyrazinamide | Dava Pharmaceuticals, Inc.
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation. Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 to 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 70 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluating the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
The table is taken from the CDC-American Thoracic Society joint recommendations:4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and AdultsDaily Dose*
Maximal Daily
Dose in
Children
and Adults
Twice Weekly Dose
Drug
Children
Adults
Children
Adults
Isoniazid
10 to 20 mg/kg
PO or IM
5 mg/kg
PO or IM
300 mg
20 to 40 mg/kg
Max. 900 mg
15 mg/kg
Max. 900 mg
Rifampin
10 to 20 mg/kg
PO
10 mg/kg
PO
600 mg
10 to 20 mg/kg
Max. 600 mg
10 mg/kg
Max. 600 mg
Pyrazinamide
15 to 30 mg/kg
PO
15 to 30 mg/kg
PO
2 g
50 to 70 mg/kg
50 to 70 mg/kg
Streptomycin
20 to 40 mg/kg
IM
15 mg/kg**
IM
1 g**
25 to 30 mg/kg
IM
25 to 30 mg/kg
IM
Ethambutol
15 to 25 mg/kg
PO
15 to 25 mg/kg
PO
2.5 g
50 mg/kg
50 mg/kg
Definition of abbreviations: PO = perorally; IM = intramuscularly.
* Doses based on weight should be adjusted as weight changes.
**In persons older than 60 yrs of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg.
- American Health Packaging
Pyrazinamide | American Health Packaging
Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation. Pyrazinamide frequently will be an important component of such therapy.
Patients with concomitant HIV infection may require longer courses of therapy. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients.
Usual dose: Pyrazinamide is administered orally, 15 to 30 mg/kg once daily. Older regimens employed 3 to 4 divided doses daily, but most current recommendations are for once a day. Three grams per day should not be exceeded. The CDC recommendations do not exceed 2 g per day when given as a daily regimen (see table).
Alternatively, a twice weekly dosing regimen (50 to 70 mg/kg twice weekly based on lean body weight) has been developed to promote patient compliance with a regimen on an outpatient basis. In studies evaluating the twice weekly regimen, doses of pyrazinamide in excess of 3 g twice weekly have been administered. This exceeds the recommended maximum 3 g/daily dose. However, an increased incidence of adverse reactions has not been reported.
Definition of abbreviations: PO = perorally; IM = intramuscularly.
* Doses based on weight should be adjusted as weight changes.
**In persons older than 60 yrs of age the daily dose of streptomycin should be limited to 10 mg/kg with a maximal dose of 750 mg.The table is taken from the CDC-American Thoracic Society joint recommendations:4
Recommended Drugs for the Initial Treatment of Tuberculosis in Children and Adults
Daily Dose*
Maximal Daily
Dose in
Children
and Adults
Twice Weekly Dose
Drug
Children
Adults
Children
Adults
Isoniazid
10 to 20 mg/kg
PO or IM
5 mg/kg
PO or IM
300 mg
20 to 40 mg/kg
Max. 900 mg
15 mg/kg
Max. 900 mg
Rifampin
10 to 20 mg/kg
PO
10 mg/kg
PO
600 mg
10 to 20 mg/kg
Max. 600 mg
10 mg/kg
Max. 600 mg
Pyrazinamide
15 to 30 mg/kg
PO
15 to 30 mg/kg
PO
2 g
50 to 70 mg/kg
50 to 70 mg/kg
Streptomycin
20 to 40 mg/kg
IM
15 mg/kg**
IM
1 g**
25 to 30 mg/kg
IM
25 to 30 mg/kg
IM
Ethambutol
15 to 25 mg/kg
PO
15 to 25 mg/kg
PO
2.5 g
50 mg/kg
50 mg/kg
![Pyrazinamide Tablet [Mikart, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=5281495e-b7cd-4f56-89ce-ac950ec1cd9c&name=5281495e-b7cd-4f56-89ce-ac950ec1cd9c-02.jpg)
![Pyrazinamide Tablet [Remedyrepack Inc. ]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=65314bad-fcc2-4e6d-b4ea-2684b7e212c5&name=MM2.jpg)
![Pyrazinamide Tablet [Versapharm Incorporated]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=ecee3128-a47f-4ced-a1db-4f58c5f3e9c6&name=ecee3128-a47f-4ced-a1db-4f58c5f3e9c6-02.jpg)
![Pyrazinamide Tablet [Remedyrepack Inc. ]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=00505856-75cc-4f66-947d-0e5e9349fc0e&name=MM2.jpg)
![Pyrazinamide Tablet [Remedyrepack Inc. ]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=999aeb7d-1f49-42b0-8b68-95fe9ae9bf9e&name=MM2.jpg)
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