FDA records indicate that there are no current recalls for this drug.
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Questions & Answers
Side Effects & Adverse Reactions
For use in dogs only. Keep this and all drugs out of reach of children. In safety studies, testicular hypoplasia was observed in some dogs receiving 3 and 5 times the maximum recommended dose monthly for 6 months (see Animal Safety).
In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
For a copy of the Material Safety Data Sheet (MSDS), or to report adverse reactions, call 1-866-337-5009.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).
History
There is currently no drug history available for this drug.
Other Information
QuadriGuard™ is a combination of three anthelmintics (ivermectin/pyrantel pamoate/praziquantel). The tablets are available in four sizes in color-coded packages for oral administration to dogs according to their weight (see Dosage).
Sources
Quadriguard Manufacturers
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Vicar Operating Inc.
Quadriguard | Vicar Operating Inc.
QuadriGuard™ (ivermectin/pyrantel pamoate/praziquantel) should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight, as follows:
Dog Weight Lbs. Chewable Tablet Per Month Tablet Size Ivermectin Content Pyrantel Pamoate Content Praziquantel Content 6.0 to 12 1 Toy 34 mcg 28.5 mg 28.5 mg 12.1 to 25 1 Small 68 mcg 57 mg 57 mg 25.1 to 50 1 Medium 136 mcg 114 mg 114 mg 50.1 to 100 1 Large 272 mcg 228 mg 228 mgQuadriGuard™ is recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these chewable tablets.
Remove only one tablet at a time from the foil-backed blister card. Return the remaining tablets to their box to protect the product from light. QuadriGuard™ can be offered to the dog by hand or be added intact to a small amount of dog food. Care should be taken that the dog consumes the complete dose, and the dog should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
QuadriGuard™ should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of QuadriGuard™ must be given within a month (30 days) of the last dose of the former medication. A heartworm test should be performed prior to switching heartworm preventive products.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with QuadriGuard™ and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.
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