Quixin
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Questions & Answers
Side Effects & Adverse Reactions
NOT FOR INJECTION.
QUIXIN® solution should not be injected subconjunctivally, nor should it be introduced directly into the anterior chamber of the eye.
In patients receiving systemic quinolones, serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported, some following the first dose. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, angioedema (including laryngeal, pharyngeal or facial edema), airway obstruction, dyspnea, urticaria and itching. If an allergic reaction to levofloxacin occurs, discontinue the drug. Serious acute hypersensitivity reactions may require immediate emergency treatment. Oxygen and airway management should be administered as clinically indicated.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
QUIXIN® solution is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms:
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| AEROBIC GRAM-POSITIVE MICROORGANISMS | AEROBIC GRAM-NEGATIVE MICROORGANISMS |
| Corynebacterium species* | Acinetobacter lwoffii* |
| Staphylococcus aureus | Haemophilus influenzae |
| Staphylococcus epidermidis | Serratia marcescens* |
| Streptococcus pneumoniae | |
| Streptococcus (Groups C/F) | |
| Streptococcus (Group G) | |
| Viridans group streptococci | |
History
There is currently no drug history available for this drug.
Other Information
QUIXIN® (levofloxacin ophthalmic solution) 0.5% is a sterile topical ophthalmic solution. Levofloxacin is a fluoroquinolone antibacterial active against a broad spectrum of Gram-positive and Gram-negative ocular pathogens. Levofloxacin is the pure (-)-(S)-enantiomer of the racemic drug substance, ofloxacin. It is more soluble in water at neutral pH than ofloxacin.
| Structural formula |
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| levofloxacin hemihydrate |
| C18H20FN3 • 1/2 H2O Mol Wt 370.38 |
(-)-(S)-9-fluoro-2 ,3-dihydro-3-methyl-10-( 4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1 ,2 ,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate.
Levofloxacin (hemihydrate) is a yellowish-white crystalline powder.
Each mL of QUIXIN® contains 5.12 mg of levofloxacin hemihydrate equivalent to 5 mg levofloxacin.
Active: Levofloxacin 0.5% (5 mg/mL); Preservative: benzalkonium chloride 0.005%; Inactives: sodium chloride and water. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.
QUIXIN® solution is isotonic and formulated at pH 6.5 with an osmolality of approximately 300 mOsm/kg. Levofloxacin is a fluorinated 4-quinolone containing a six-member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure.
Sources
Quixin Manufacturers
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Vistakon Pharmaceuticals Llc
![Quixin (Levofloxacin) Solution [Vistakon Pharmaceuticals Llc]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Quixin | Vistakon Pharmaceuticals Llc
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