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Questions & Answers
Side Effects & Adverse Reactions
Induction of anesthesia with RapinovetTM injection is frequently associated with apnea and respiratory depression. Hypotension and oxygen desaturation can occur also, especially following rapid bolus administration. Apnea is observed less frequently following maintenance doses of RapinovetTM injection when given as the sole maintenance agent, or when a maintenance dose is administered during inhalant anesthesia.
When using Rapinovet™ injection, patients should be continuously monitored, and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The clinical use of propofol without available supplemental oxygen and artificial ventilation has not been adequately evaluated and is not recommended.
The primary side effect of RapinovetTM injection in dogs is respiratory depression and apnea. Apnea was observed in 20% of the dog cases in the clinical trial. Apnea was observed in 1.4% of the cat cases in the clinical trial. All apnea cases responded satisfactorily to oxygen supplementation and/or controlled ventilation.
Apnea lasting less than 1 minute in healthy dogs or cats may cause no harm. Animals breathing atmospheric air that become apneic may show signs of cerebral damage after 2 minutes. Animals breathing 100% oxygen that become apneic may not show signs of cerebral damage for 5 to 8 minutes. Ventricular arrhythmias may occur secondary to hypoxia induced by apnea.
The primary side effect of RapinovetTM injection in cats is paddling during recovery. Paddling was observed in 11% of, the cat cases in the clinical trial.
Other transient side effects in dogs or cats are observed infrequently or rarely:
•Respiratory: panting, reverse sneezing, cyanosis • Musculoskeletal: paddling during recovery, tremors, tenseness, movements, fasciculations. •Cardiovascular: bradycadia, hypotension, cyanosis, tachycardia, premature ventricular contractions •Central Nervous System: .excitation, opisthotonus, seizure •Injection Site: pain during injection •Gastrointestinal: emesis/retching •Other: rubbing at face or nose during recovery, vocalization during recovery, chewing or licking the injection site during recovery.
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FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
RapinovetTM (propofol) is an anesthetic injection for use in dogs and cats as follows:
1. As a single injection to provide general anesthesia for short procedures.
2. For induction and maintenance of general anesthesia using incremental doses to effect.
3. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Induction of general anesthesia will usually be observed within 30 to 60 seconds after the end of administration (administration should take 60 to 90 seconds).The doses for induction and maintenance vary depending upon species and preanesthetics. The duration of anesthesia varies depending upon species, dose, and preanesthetics.
In dogs, the duration of anesthesia following the recommended induction dose (5.5 to 7.0 mg/kg without premedication) is generally 5 to 7 minutes. The duration of anesthesia after maintenance doses varies from 2 to 6 minutes following 1.1 mg/kg to 6 to 10 minutes following 3.3 mg/kg. Full standing recovery is generally observed within 10 to 20 minutes after the end of anesthesia, regardless of the duration of anesthesia. Recovery may be delayed in sighthounds or if preanesthetics are administered.
In cats, the duration of anesthesia following the recommended induction dose (8.0 to 13.2 mg/kg without premedication) is generally 5 to 12 minutes. The duration of anesthesia after maintenance doses varies from 5 to 7 minutes following 1.1 mg/kg to 12 to 18 minutes following 4.4 mg/kg. Full standing recovery is generally observed within 30 to 45 minutes after the end of anesthesia, regardless of the duration of anesthesia. Recovery may be delayed if preanesthetics are administered
There is currently no drug history available for this drug.
Rapinovet™ (propofol) injection is a sterile, nonpyrogenic emulsion containing 10mg/mL of propofol suitable for intravenous administration. Propofol is chemically described as 2, 6-diisopropylphenol and has a molecular weight of 178.28. Propofol is very slightly soluble in water and is therefore formulated as a white, oil-in-water emulsion. Each mL contains propofol (10 mg), soybean oil (100 mg), glycerol (22.5 mg), egg yolk phospholipid (12 mg) and sodium metabisulfite (0.25 mg), with sodium hydroxide to adjust the pH. The propofol emulsion is isotonic and has a pH of 4.5-6.6.