Renvela

Renvela

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Questions & Answers

Side Effects & Adverse Reactions

There is currently no warning information available for this product. We apologize for any inconvenience.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Renvela® (sevelamer carbonate) is indicated for the control of serum phosphorus in patients with chronic kidney disease (CKD) on dialysis. 

History

There is currently no drug history available for this drug.

Other Information

The active ingredient in Renvela is sevelamer carbonate, a polymeric amine that binds phosphate and is meant for oral administration. It was developed as a pharmaceutical alternative to sevelamer hydrochloride (Renagel®). Sevelamer carbonate is an anion exchange resin, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. While the counterions differ for the two salts, the polymer itself, the active moiety involved in phosphate binding, is the same.

Renvela (sevelamer carbonate) is known chemically as poly(allylamine-co-N,N’-diallyl-1,3-diamino-2-hydroxypropane) carbonate salt. Sevelamer carbonate is hygroscopic, but insoluble in water. The structure is represented in Figure 1.

Figure 1. Chemical Structure of Sevelamer Carbonate

Chemical Structure of Sevelamer Carbonate

a, b = number of primary amine groups     a + b = 9
c = number of crosslinking groups            c = 1
m = large number to indicate extended polymer network

Renvela® Tablets: Each film-coated tablet of Renvela contains 800 mg of sevelamer carbonate on an anhydrous basis. The inactive ingredients are hypromellose, diacetylated monoglycerides, microcrystalline cellulose, sodium chloride and zinc stearate. The tablet imprint contains iron oxide black ink.

Renvela Manufacturers


  • Kaiser Foundation Hospitals
    Renvela (Sevelamer Carbonate) Tablet, Film Coated [Kaiser Foundation Hospitals]
  • Cardinal Health
    Renvela (Sevelamer Carbonate) Tablet, Film Coated [Cardinal Health]
  • Carilion Materials Management
    Renvela (Sevelamer Carbonate) Tablet, Film Coated [Carilion Materials Management]
  • Genzyme Corporation
    Renvela (Sevelamer Carbonate) Tablet, Film Coated Renvela (Sevelamer Carbonate) Powder, For Suspension [Genzyme Corporation]

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