Reserpine
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Questions & Answers
Side Effects & Adverse Reactions
Extreme caution should be exercised in treating patients with a history of mental depression. Reserpine may cause mental depression. Recognition of depression may be difficult because this condition may often be disguised by somatic complaints (Masked Depression). The drug should be discontinued at first signs of depression such as despondency, early morning insomnia, loss of appetite, impotence, or self-deprecation. Drug-induced depression may persist for several months after drug withdrawal and may be severe enough to result in suicide.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Mild essential hypertension; also useful as adjunctive therapy with other antihypertensive agents in the more severe forms of hypertension; relief of symptoms in agitated psychotic states (e.g., schizophrenia), primarily in those individuals unable to tolerate phenothiazine derivatives or in those who also require antihypertensive medication.
History
There is currently no drug history available for this drug.
Other Information
Reserpine, USP is an antihypertensive, available as 0.1 mg and 0.25 mg tablets for oral administration. Its chemical name is methyl 18β-hydroxy-11,17 α-dimethoxy-3β, 20α-yohimban-16β-carboxylate 3,4,5-trimethoxybenzoate (ester) and its structural formula is:
Reserpine USP, a pure crystalline alkaloid of rauwolfia, is a white or pale buff to slightly yellowish, odorless crystalline powder. It darkens slowly on exposure to light, but more rapidly when in solution. It is insoluble in water, freely soluble in acetic acid and in chloroform, slightly soluble in benzene, and very slightly soluble in alcohol and in ether. Its molecular weight is 608.69.
Inactive Ingredients: Acacia, confectioner’s sugar1, corn starch, lactose monohydrate, magnesium stearate.
This product complies with Dissolution Test #2.
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In 0.25 mg tablets only.
Sources
Reserpine Manufacturers
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Eon Labs, Inc.
![Reserpine Tablet [Eon Labs, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Reserpine | Eon Labs, Inc.
HypertensionIn the average patient not receiving other antihypertensive agents, the usual initial dosage is 0.5 mg daily for 1 or 2 weeks., For maintenance, reduce to 0.1-0.25 mg daily. Higher dosages should be used cautiously, because occurrence of serious mental depression and other side effects may increase considerably.
Psychiatric DisordersThe usual initial dosage is 0.5 mg daily, but may range from 0.1 mg to 1.0 mg. Adjust dosage upward or downward according to the patient's response.
ChildrenReserpine is not recommended for use in children (see PRECAUTIONS: Pediatric Use). If it is to be used in treating a child, the usual recommended starting dose is 20 µg/kg daily. The maximum recommended dose is 0.25 mg (total) daily.
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