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Questions & Answers

Side Effects & Adverse Reactions

Salix® is a highly effective diuretic and if given in excessive amounts as with any diuretic may lead to excessive diuresis which could result in electrolyte imbalance, dehydration and reduction of plasma volume enhancing the risk of circulatory collapse, thrombosis, and embolism. Therefore, the animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures administered. Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids.

It is important to correct potassium deficiency with dietary supplementation. Caution should be exercised in prescribing enteric-coated potassium tablets.

There have been several reports in human literature, published and unpublished, concerning nonspecific small-bowel lesions consisting of stenosis, with or without ulceration, associated with the administration of enteric-coated thiazides with potassium salts.

These lesions may occur with enteric-coated potassium tablets alone or when they are used with nonenteric-coated thiazides, or certain other oral diuretics. These small-bowel lesions may have caused obstruction, hemorrhage, and perforation. Surgery was frequently required, and deaths have occured. Available information tends to implicate enteric-coated potassium salts, although lesions of this type also occur spontaneously. Therefore, coated potassium-containing formulations should be administered only when indicated and should be discontinued immediately if abdominal pain, distention, nausea, vomiting, or gastro-intestinal bleeding occurs.

Human patients with known sulfonamide sensitivity may show allergic reactions to Salix®; however, these reactions have not been reported in animals.

Sulfonamide diuretics have been reported to decrease arterial responsiveness to pressor amines and to enhance the effect of tubocurarine. Caution should be exercised in administering curare or its derivatives to patients undergoing therapy with Salix® and it is advisable to discontinue Salix® for one day prior to any elective surgery.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Dogs and Cats

Salix® is an effective diuretic possessing a wide therapeutic range. Pharmacologically it promotes the rapid removal of abnormally retained extracellular fluids. The rationale for the efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. Salix® is indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.

The continued use of heart stimulants, such as digitalis or its glycosides is indicated in cases of edema involving cardiac insufficiency.


There is currently no drug history available for this drug.

Other Information

Salix® (furosemide) is a chemically distinct diuretic and saluretic pharmacodynamically characterized by the following:

1) A high degree of efficacy, low-inherent toxicity and a high therapeutic index.

2) A rapid onset of action and of comparatively short duration.

3) A pharmacological action in the functional area of the nephron, i.e., proximal and distal tubules and the ascending limb of the loop of Henle.

4) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold.

5) It may be administered orally or parenterally.

It is readily absorbed from the intestinal tract and well tolerated.

The intravenous route produces the most rapid diuretic response.

The CAS Registry Number is 54-31-9.

Salix®, a diuretic, is an anthranilic acid derivative with the following structural formula:

Chemical Structure

Generic name: Furosemide (except in United Kingdom-furosemide).

Chemical name: 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.

Salix Manufacturers

  • Schering Corporation
    Salix (Furosemide) Tablet [Schering Corporation]
  • Merck Sharp & Dohme Corp.
    Salix (Furosemide) Injection [Merck Sharp & Dohme Corp.]

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