Sedivet
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Questions & Answers
Side Effects & Adverse Reactions
Not for human use. Keep this and all drugs out of the reach of children.
Do not use in horses intended for human consumption.
Although apparently deeply sedated, some horses may still respond to external stimuli with defensive movements (for example, kicking). Sedated horses are frequently ataxic. Routine safety measures should be used to protect practitioners and handlers.
Romifidine hydrochloride can be absorbed and may cause irritation following direct exposure to skin, eyes or mouth. In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing. In case of accidental oral exposure or injection, seek medical attention. If irritation or other adverse reaction occurs (for example, sedation, hypotension, bradycardia), seek medical attention.
As with all injectable drugs causing profound physiological effects, precautions should be taken by practitioners to prevent accidental self-injection when handling and using filled syringes. Users receiving treatment for blood pressure abnormalities should take special precaution to avoid exposure to this product.
Note to Physician: This product contains an α2- adrenoceptor agonist and can be absorbed by oral and dermal routes.
Legal Issues
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FDA Safety Alerts
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Manufacturer Warnings
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FDA Labeling Changes
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Uses
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History
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Other Information
Sedivet 1.0% Injection (romifidine hydrochloride) is an α2-adrenoceptor agonist with sedative and analgesic properties. The chemical name is 2-bromo-6-fluoro-2-imidazolidinylidenbenzamine-monohydrochloride. It is a crystalline, white, odorless, water soluble substance with a molecular formula of C9H9BrFN3•HCl, and a molecular weight of 294.56. Each mL contains 10 mg romifidine hydrochloride, 6.5 mg sodium chloride, 2 mg chlorocresol, and water for injection.
Sources
Sedivet Manufacturers
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Boehringer Ingelheim Vetmedica, Inc.
![Sedivet (Romifidine Hydrochloride) Injection [Boehringer Ingelheim Vetmedica, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Sedivet | Boehringer Ingelheim Vetmedica, Inc.
Sedation and Analgesia Dose: Administer slowly as a single IV injection using a dosage range of 40 - 120 μg/kg (0.4 - 1.2 mL/100 kg body weight) depending on the depth and duration of sedation that is required. The onset of action occurs in 30 seconds to 5 minutes, and gradually subsides during the next 2 to 4 hours. Degree of sedation and analgesia is dose-and time-dependent; therefore, more profound analgesia will occur with larger doses, as well as closer to the time of injection.
Note: The animal should be allowed to rest quietly for several minutes prior to and following injection.
Note: The duration of analgesia is shorter than the duration of sedation.
Sedation Dose Onsert of Sedation* Duration of Sedation Onset of Analgesia Duration of Analgesia 40 μg/kg (0.4 mL/100 kg) 2-4 minutes 75 minutes 5 minutes 30 minutes 120 μg/kg (1.2 mL/100 kg) 2-4 minutes 3 hours 5 minutes 150 minutes* Times reported are from the sedation dose confirmation study (see Effectiveness).
Preanesthesia Dose: A single IV injection using a dose of 100 μg/kg (1.0 mL/100 kg body weight) was shown to be effective in the preanesthesia dose confirmation study (see Effectiveness). Anesthesia should be induced after maximum sedation is achieved. The administration of α2-agonists results in anesthetic sparing effects1,2; therefore, anesthetic doses should be reduced to avoid overdose.
Mild to moderate sedation occurs within 2-4 minutes. Following induction, lateral recumbency occurs within 4 minutes, followed by complete anesthesia within 6-16 minutes. During recovery from anesthesia, sternal recumbency occurs within 12-83 minutes, followed by standing in 17-84 minutes. Recovery time is primarily determined by the choice of induction anesthetic and/or the duration of anesthesia.
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