Seromycin
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Questions & Answers
Side Effects & Adverse Reactions
Administration of Seromycin should be discontinued or the dosage reduced if the patient develops allergic dermatitis or symptoms of CNS toxicity, such as convulsions, psychosis, somnolence, depression, confusion, hyperreflexia, headache, tremor, vertigo, paresis, or dysarthria.
The toxicity of Seromycin is closely related to excessive blood levels (above 30as determined by high dosage or inadequate renal clearance. The ratio of toxic dose to effective dose in tuberculosis is small.
The risk of convulsions is increased in chronic alcoholics.
Patients should be monitored by hematologic, renal excretion, blood level, and liver function studies.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Seromycin is indicated in the treatment of active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible to this drug and when treatment with the primary medications (streptomycin, isoniazid, rifampin, and ethambutol) has proved inadequate. Like all antituberculosis drugs, Seromycin should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent.
Seromycin may be effective in the treatment of acute urinary tract infections caused by susceptible strains of grampositive and gramnegative bacteria, especially Enterobacter spp. and Escherichia coli. It is generally no more and is usually less effective than other antimicrobial agents in the treatment of urinary tract infections caused by bacteria other than mycobacteria. Use of Seromycin in these infections should be considered only when more conventional therapy has failed and when the organism has been demonstrated to be susceptible to the drug.
History
There is currently no drug history available for this drug.
Other Information
Seromycin(Cycloserine Capsules, USP), 3-isoxazolidinone, 4-amino, (R)is a broadspectrum antibiotic that is produced by a strain of Streptomyces orchidaceus and has also been synthesized. Cycloserine is a white to offwhite powder that is soluble in water and stable in alkaline solution. It is rapidly destroyed at a neutral or acid pH.
Cycloserine has a pH between 5.5 and 6.5 in a solution containing 100 mg/mL. The molecular weight of cycloserine is 102.09, and it has an empirical formula of C3H6N2O2. The structural formula of cycloserine is as follows:
Sources
Seromycin Manufacturers
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Remedyrepack Inc.
![Seromycin (Cycloserine) Capsule [Remedyrepack Inc. ]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Seromycin | Remedyrepack Inc.
Seromycin is effective orally and is currently administered only by this route. The usual dosage is 500 mg to 1 g daily in divided doses monitored by blood levels.2 The initial adult dosage most frequently given is 250 mg twice daily at 12hour intervals for the first 2 weeks. A daily dosage of 1 g should not be exceeded.
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Purdue Gmp Center Llc Dba The Chao Center
Seromycin | Purdue Gmp Center Llc Dba The Chao Center
Seromycin is effective orally and is currently administered only by this route. The usual dosage is 500 mg to 1 g daily in divided doses monitored by blood levels.2 The initial adult dosage most frequently given is 250 mg twice daily at 12–hour intervals for the first 2 weeks. A daily dosage of 1 g should not be exceeded.
![Seromycin (Cycloserine) Capsule [Purdue Gmp Center Llc Dba The Chao Center]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=e1e08327-4b90-463e-bb2a-22438cabcef2&name=Purdue_GMP_seromycin.jpg)
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