Sevelamer Carbonate

Sevelamer Carbonate

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Questions & Answers

Side Effects & Adverse Reactions

There is currently no warning information available for this product. We apologize for any inconvenience.

Legal Issues

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FDA Safety Alerts

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Manufacturer Warnings

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FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Sevelamer carbonate is indicated for the control of serum phosphorus in patients with chronic kidney disease (CKD) on dialysis.

History

There is currently no drug history available for this drug.

Other Information

The active ingredient is sevelamer carbonate, a polymeric amine that binds phosphate and is meant for oral administration. It was developed as a pharmaceutical alternative to sevelamer hydrochloride. Sevelamer carbonate is an anion exchange resin, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. While the counterions differ for the two salts, the polymer itself, the active moiety involved in phosphate binding, is the same.

Sevelamer carbonate is known chemically as poly(allylamine-co-N,N'-diallyl-1,3-diamino-2-hydroxypropane) carbonate salt. Sevelamer carbonate is hygroscopic, but insoluble in water. The structure is represented in Figure 1.

a, b = number of primary amine groups       a + b = 9
c = number of crosslinking groups               c = 1
m = large number to indicate extended polymer network
Figure 1. Chemical Structure of Sevelamer Carbonate
Chemical Structure

Sevelamer Carbonate Tablets: Each film-coated tablet contains 800 mg of sevelamer carbonate on an anhydrous basis. The inactive ingredients are hypromellose, diacetylated monoglycerides, microcrystalline cellulose, sodium chloride and zinc stearate. The tablet imprint contains iron oxide black ink.

Sevelamer Carbonate Powder: Each packet contains 0.8 g or 2.4 g of sevelamer carbonate on an anhydrous basis. The inactive ingredients are natural and artificial citrus flavor, propylene glycol alginate, sodium chloride, sucralose, and ferric oxide (yellow).

Sevelamer Carbonate Manufacturers


  • Global Pharmaceuticals Division Of Impax Laboratories, Inc.
    Sevelamer Carbonate Tablet, Film Coated [Global Pharmaceuticals Division Of Impax Laboratories, Inc.]

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