The introduction of additives to any solution, regardless of type of container, requires special attention to ensure that no incompatibilities result. While some incompatibilities are readily absorbed, one must be aware that subtle physical, chemical and pharmacological incompatibilities can occur. The medical literature, the package insert and other available sources of information should be reviewed for thorough understanding of possible incompatibilities.
Sykes Electrolyte Solution Compound Sodium Lactate (Hartmann’s Solution) should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there exists edema and sodium retention.
Sykes Electrolyte Solution Compound Sodium Lactate (Hartmann’s Solution) should be used with great care, if at all, in patients with hyperkalemia, severe renal failure, and in conditions in which potassium retention is present.
Sykes Electrolyte Solution Compound Sodium Lactate (Hartmann’s Solution) should be used with great care in patients with metabolic or respiratory alkalosis. The administration of lactate ions should be done with great care in those conditions in which there is an increased level or an impaired utilization of these ions, such as severe hepatic insufficiency.
Sykes Electrolyte Solution Compound Sodium Lactate (Hartmann’s Solution) should not be administered simultaneously with blood through the same administration set because of likelihood of coagulation.
The intravenous administration of Sykes Electrolyte Solution Compound Sodium Lactate (Hartmann’s Solution) can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, over-hydration, congested states, or pulmonary edema. The risk of dilutional states is inversely proportional to the electrolyte concentrations of the injections. The risk of solute overloading causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injections.
In patients with diminished renal function, administration of Sykes Electrolyte Solution Compound Sodium Lactate (Hartmann’s Solution) may result in sodium or potassium retention.
Do not administer to horses by intraperitoneal injection. Do not administer to animals with inadequate renal function. Not for use in lactic acidosis.
There is currently no manufacturer warning information available for this drug.
Sykes Electrolyte Solution Compound Sodium Lactate (Hartmann’s Solution) is indicated as a source of water and electrolytes for all species. It is also used as an alkalinizing agent.
Sykes Electrolyte Solution Compound Sodium Lactate (Hartmanns Solution) is a sterile, non-pyrogenic solution intended for fluid and electrolyte replenishment in single dose containers. May be administered intravenously, subcutaneously or intraperitoneally (except in horses) using aseptic technique. It contains no antimicrobial agents. Discard any unused portion. Composition, osmolarity, pH and ionic concentration are shown in Table 1.
Table 1
| Composition (g/L) | Sodium Chloride | Potassium Chloride | Calcium Chloride | Sodium Lactate* | |
| 6.0 | 0.40 | 0.28 | 3.24 | ||
| Ionic Concentration (mEq/L) | Sodium | Potassium | Calcium | Chloride | Lactate |
| 131 | 5 | 2 | 111 | 29 |
*Sodium Lactate USP (S)-enantiomer
Osmolarity (mOsmol/L) (calc): 280mOsmol per litre
pH: 6.5 (limit 6.0 7.0)
The container is free of PVC and phthalates. It is fabricated from 5 layer polyolefin based co-extrusion material. The container meets the requirements of USP (Class VI) and is registered under US FDA DMF#9705.