Simplicef
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Other Information
Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic cephalosporin antibiotic. The chemical name is: (+/-)-1-Hydroxyethyl(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 72-(Z)-(Omethyloxime), isopropyl carbonate (ester) [87239-81-4].
Cefpodoxime proxetil Chemical Structure:
Cefpodoxime proxetil is a prodrug; its active metabolite is cefpodoxime. All doses of SIMPLICEF (cefpodoxime proxetil) tablets are expressed in terms of the active cefpodoxime moiety. SIMPLICEF is available as:
100 mg Tablet, each reddish-orange, elliptical, scored tablet contains cefpodoxime proxetil equivalent to 100 mg of cefpodoxime.
200 mg Tablet, each light orange, round rectangle, scored tablet contains cefpodoxime proxetil equivalent to 200 mg of cefpodoxime.
Sources
Simplicef Manufacturers
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Zoetis Inc.
![Simplicef (Cefpodoxime Proxetil) Tablet [Zoetis Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Simplicef | Zoetis Inc.
Dose range: The dose range of SIMPLICEF (cefpodoxime proxetil) tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient's host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.
Duration: SIMPLICEF tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections should not be continued for more than 3-4 days if no response to therapy is seen.
Dosing Charts: For daily oral administration of SIMPLICEF at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).
Table 1. Dose Table for SIMPLICEF Tablets at 5 mg/kg Total Daily Dosage Weight of Dog (lbs) Daily Dose 22 44 66 88 132 No. of 100 mg tablets 0.5 1 1.5 1 No. of 200 mg tablets 1 1 Weight of Dog (kgs) Daily Dose 10 20 30 40 60 No. of 100 mg tablets 0.5 1 1.5 1 No. of 200 mg tablets 1 1 Table 2. Dose Table for SIMPLICEF Tablets at 10 mg/kg Total Daily Dosage Weight of Dog (lbs) Daily Dose 11 22 44 66 88 132 No. of 100 mg tablets 0.5 1 1 No. of 200 mg tablets 1 1 2 3 Weight of Dog (kgs) Daily Dose 5 10 20 30 40 60 No. of 100 mg tablets 0.5 1 1 No. of 200 mg tablets 1 1 2 3
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