Slentrol Recall

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Questions & Answers

Side Effects & Adverse Reactions

Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

WARNINGS: Not for use in humans. Keep this and all drugs out of reach of children.

Adverse reactions associated with humans ingesting dirlotapide include: abdominal distention, abdominal pain, diarrhea, flatulence, headache, increased serum transaminases, nausea, and vomiting.

SLENTROL may cause eye-irritation. If accidental eye exposure occurs, flush the eyes immediately with clean water.

In some cases aggression has been reported in dogs being treated with SLENTROL. In case of aggression SLENTROL treatment should be discontinued until a veterinarian is consulted.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


INDICATIONS: SLENTROL (dirlotapide) Oral Solution is indicated for the management of obesity in dogs.


There is currently no drug history available for this drug.

Other Information

DESCRIPTION: Slentrol (dirlotapide) is a solution formulated at a concentration of 5 mg/mL of dirlotapide for oral administration to dogs. Dirlotapide is a selective microsomal triglyceride transfer protein inhibitor that blocks the assembly and release of lipoprotein particles into the bloodstream (via the lymphatic system) in dogs.1

The empirical formula is C40H33F3N4O3 and the molecular weight is 674.73. The chemical name is (S)-N-{2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1H-indole-2-carboxamide.

The chemical structure of dirlotapide is:

Chemical Structure

Slentrol Manufacturers

  • Zoetis Inc.
    Slentrol (Dirlotapide) Solution [Zoetis Inc.]

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